{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2009:RBWWZCSOJ4JUVHDE7R3FTYHQKH","short_pith_number":"pith:RBWWZCSO","canonical_record":{"source":{"id":"0912.4710","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2009-12-23T19:04:10Z","cross_cats_sorted":["physics.bio-ph","q-bio.MN","q-bio.QM"],"title_canon_sha256":"2a0729b3aa3050347826060db5cbbe3902957474daeb99ee0d71c18b3cbb600d","abstract_canon_sha256":"a94a452e46eb1e953cb788d3bd35728b82237253f6a44c2fd629bbdcd94f0b71"},"schema_version":"1.0"},"canonical_sha256":"886d6c8a4e4f134a9c64fc7659e0f051d02b8b5304b7505a3f6998809038fcc5","source":{"kind":"arxiv","id":"0912.4710","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0912.4710","created_at":"2026-05-18T04:28:48Z"},{"alias_kind":"arxiv_version","alias_value":"0912.4710v2","created_at":"2026-05-18T04:28:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0912.4710","created_at":"2026-05-18T04:28:48Z"},{"alias_kind":"pith_short_12","alias_value":"RBWWZCSOJ4JU","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_16","alias_value":"RBWWZCSOJ4JUVHDE","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_8","alias_value":"RBWWZCSO","created_at":"2026-05-18T12:26:01Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2009:RBWWZCSOJ4JUVHDE7R3FTYHQKH","target":"record","payload":{"canonical_record":{"source":{"id":"0912.4710","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2009-12-23T19:04:10Z","cross_cats_sorted":["physics.bio-ph","q-bio.MN","q-bio.QM"],"title_canon_sha256":"2a0729b3aa3050347826060db5cbbe3902957474daeb99ee0d71c18b3cbb600d","abstract_canon_sha256":"a94a452e46eb1e953cb788d3bd35728b82237253f6a44c2fd629bbdcd94f0b71"},"schema_version":"1.0"},"canonical_sha256":"886d6c8a4e4f134a9c64fc7659e0f051d02b8b5304b7505a3f6998809038fcc5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:28:48.639954Z","signature_b64":"V3nwniBCXhFYCH+it44k7W/DQ8/x5XXosYPZVaUYhoYeN4OzmthdcMqcEMiTC5Yar/uqsnhsgh9FXlNjWnU7Aw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"886d6c8a4e4f134a9c64fc7659e0f051d02b8b5304b7505a3f6998809038fcc5","last_reissued_at":"2026-05-18T04:28:48.639142Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:28:48.639142Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0912.4710","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:28:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nrRqXHkcKnZ5EredsPaXt+7euJ8gFPoDsletXEK/IQPv+ixZVD0X0Cs5SBibeAJUBkciy+IwuNp/ES4KDDlvCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T23:06:52.170142Z"},"content_sha256":"fa2072e9a12ce2cfebee16b8d136756437d15ca72a5315cd7f6bdb8453541f6a","schema_version":"1.0","event_id":"sha256:fa2072e9a12ce2cfebee16b8d136756437d15ca72a5315cd7f6bdb8453541f6a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2009:RBWWZCSOJ4JUVHDE7R3FTYHQKH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Enzymatic Logic Gates with Noise-Reducing Sigmoid Response","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.MN","q-bio.QM"],"primary_cat":"cond-mat.soft","authors_text":"Aleksandr Simonian, Dmitriy Melnikov, Evgeny Katz, Jan Halamek, Marcos Pita, Valber Pedrosa, Vladimir Privman","submitted_at":"2009-12-23T19:04:10Z","abstract_excerpt":"Biochemical computing is an emerging field of unconventional computing that attempts to process information with biomolecules and biological objects using digital logic. In this work we survey filtering in general, in biochemical computing, and summarize the experimental realization of an AND logic gate with sigmoid response in one of the inputs. The logic gate is realized with electrode-immobilized glucose-6-phosphate dehydrogenase enzyme that catalyzes a reaction corresponding to the Boolean AND functions. A kinetic model is also developed and used to evaluate the extent to which the perform"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0912.4710","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:28:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NYqR336/K31HWqx86GsVEyxyB3bjglgISICNjGgsma+IbNG0cCpBxQRwCSixJLoDqIvEcBoNbD+lR3hXXjIUDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T23:06:52.170505Z"},"content_sha256":"9eed478fd2f27a8aa0d978955f52ec571c3872ee773c941c5e784afc6ebc4460","schema_version":"1.0","event_id":"sha256:9eed478fd2f27a8aa0d978955f52ec571c3872ee773c941c5e784afc6ebc4460"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/RBWWZCSOJ4JUVHDE7R3FTYHQKH/bundle.json","state_url":"https://pith.science/pith/RBWWZCSOJ4JUVHDE7R3FTYHQKH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/RBWWZCSOJ4JUVHDE7R3FTYHQKH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T23:06:52Z","links":{"resolver":"https://pith.science/pith/RBWWZCSOJ4JUVHDE7R3FTYHQKH","bundle":"https://pith.science/pith/RBWWZCSOJ4JUVHDE7R3FTYHQKH/bundle.json","state":"https://pith.science/pith/RBWWZCSOJ4JUVHDE7R3FTYHQKH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/RBWWZCSOJ4JUVHDE7R3FTYHQKH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:RBWWZCSOJ4JUVHDE7R3FTYHQKH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a94a452e46eb1e953cb788d3bd35728b82237253f6a44c2fd629bbdcd94f0b71","cross_cats_sorted":["physics.bio-ph","q-bio.MN","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2009-12-23T19:04:10Z","title_canon_sha256":"2a0729b3aa3050347826060db5cbbe3902957474daeb99ee0d71c18b3cbb600d"},"schema_version":"1.0","source":{"id":"0912.4710","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0912.4710","created_at":"2026-05-18T04:28:48Z"},{"alias_kind":"arxiv_version","alias_value":"0912.4710v2","created_at":"2026-05-18T04:28:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0912.4710","created_at":"2026-05-18T04:28:48Z"},{"alias_kind":"pith_short_12","alias_value":"RBWWZCSOJ4JU","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_16","alias_value":"RBWWZCSOJ4JUVHDE","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_8","alias_value":"RBWWZCSO","created_at":"2026-05-18T12:26:01Z"}],"graph_snapshots":[{"event_id":"sha256:9eed478fd2f27a8aa0d978955f52ec571c3872ee773c941c5e784afc6ebc4460","target":"graph","created_at":"2026-05-18T04:28:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Biochemical computing is an emerging field of unconventional computing that attempts to process information with biomolecules and biological objects using digital logic. In this work we survey filtering in general, in biochemical computing, and summarize the experimental realization of an AND logic gate with sigmoid response in one of the inputs. The logic gate is realized with electrode-immobilized glucose-6-phosphate dehydrogenase enzyme that catalyzes a reaction corresponding to the Boolean AND functions. A kinetic model is also developed and used to evaluate the extent to which the perform","authors_text":"Aleksandr Simonian, Dmitriy Melnikov, Evgeny Katz, Jan Halamek, Marcos Pita, Valber Pedrosa, Vladimir Privman","cross_cats":["physics.bio-ph","q-bio.MN","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2009-12-23T19:04:10Z","title":"Enzymatic Logic Gates with Noise-Reducing Sigmoid Response"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0912.4710","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:fa2072e9a12ce2cfebee16b8d136756437d15ca72a5315cd7f6bdb8453541f6a","target":"record","created_at":"2026-05-18T04:28:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a94a452e46eb1e953cb788d3bd35728b82237253f6a44c2fd629bbdcd94f0b71","cross_cats_sorted":["physics.bio-ph","q-bio.MN","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2009-12-23T19:04:10Z","title_canon_sha256":"2a0729b3aa3050347826060db5cbbe3902957474daeb99ee0d71c18b3cbb600d"},"schema_version":"1.0","source":{"id":"0912.4710","kind":"arxiv","version":2}},"canonical_sha256":"886d6c8a4e4f134a9c64fc7659e0f051d02b8b5304b7505a3f6998809038fcc5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"886d6c8a4e4f134a9c64fc7659e0f051d02b8b5304b7505a3f6998809038fcc5","first_computed_at":"2026-05-18T04:28:48.639142Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:28:48.639142Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"V3nwniBCXhFYCH+it44k7W/DQ8/x5XXosYPZVaUYhoYeN4OzmthdcMqcEMiTC5Yar/uqsnhsgh9FXlNjWnU7Aw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:28:48.639954Z","signed_message":"canonical_sha256_bytes"},"source_id":"0912.4710","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:fa2072e9a12ce2cfebee16b8d136756437d15ca72a5315cd7f6bdb8453541f6a","sha256:9eed478fd2f27a8aa0d978955f52ec571c3872ee773c941c5e784afc6ebc4460"],"state_sha256":"fc2c29ebb68e2759b6cdd7eabfd57308ddd5f110d59762aebf5c2f4b13830ab3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jQItXEDr585FrHyeB2C9fXovApXlTNOvC+MLm9lVgt8nZLsGjJ73Hx5MtDhxMz1BU20DVvnNSmj7g472phjYAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T23:06:52.172466Z","bundle_sha256":"ad4b953382d157bc553a861ec78b3cc83b7ec146ba51456b1f4ba32232a54144"}}