{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:REYI24CEUYC3YM7QQVD2ZGANOL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5356aa0f269523b4471aee9a357159a31e898e82665ef2d42c567a39bd302902","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-04-29T09:19:40Z","title_canon_sha256":"d9eb19814bc5463123d8953c05bbce11b2f97665f4095501909920fddea43de7"},"schema_version":"1.0","source":{"id":"1404.7281","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1404.7281","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"arxiv_version","alias_value":"1404.7281v1","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1404.7281","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"pith_short_12","alias_value":"REYI24CEUYC3","created_at":"2026-05-18T12:28:46Z"},{"alias_kind":"pith_short_16","alias_value":"REYI24CEUYC3YM7Q","created_at":"2026-05-18T12:28:46Z"},{"alias_kind":"pith_short_8","alias_value":"REYI24CE","created_at":"2026-05-18T12:28:46Z"}],"graph_snapshots":[{"event_id":"sha256:47197cb8f7765561cee8f8d327e852baaab651adc2afd7cd33b197ff968721ea","target":"graph","created_at":"2026-05-18T02:52:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Transcriptional regulation of gene expression is one of the main processes that affect cell diversification from a single set of genes. Regulatory proteins often interact with DNA regions located distally from the transcription start sites (TSS) of the genes. We developed a computational method that combines open chromatin and gene expression information for a large number of cell types to identify these distal regulatory elements. Our method builds correlation graphs for publicly available DNase-seq and exon array datasets with matching samples and uses graph-based methods to filter findings ","authors_text":"Sofie Demeyer, Tom Michoel","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-04-29T09:19:40Z","title":"Graph-based data integration predicts long-range regulatory interactions across the human genome"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1404.7281","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:25328277b8b09c8c0091d8b1014b36bca68aa71d66755637bd7bbdf846faf02a","target":"record","created_at":"2026-05-18T02:52:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5356aa0f269523b4471aee9a357159a31e898e82665ef2d42c567a39bd302902","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-04-29T09:19:40Z","title_canon_sha256":"d9eb19814bc5463123d8953c05bbce11b2f97665f4095501909920fddea43de7"},"schema_version":"1.0","source":{"id":"1404.7281","kind":"arxiv","version":1}},"canonical_sha256":"89308d7044a605bc33f08547ac980d72d055e0dcf6ecb1014f9614e5a14fc9f9","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"89308d7044a605bc33f08547ac980d72d055e0dcf6ecb1014f9614e5a14fc9f9","first_computed_at":"2026-05-18T02:52:57.018365Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:52:57.018365Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"/9zXxRRKHzhYdIRGSJgWbunGnkG4l/Hi8tcL9Oe14AvKDTRRV5t9ErWC0hvGHiwT3cGkNnE+PklUiA1+XaymDA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:52:57.019110Z","signed_message":"canonical_sha256_bytes"},"source_id":"1404.7281","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:25328277b8b09c8c0091d8b1014b36bca68aa71d66755637bd7bbdf846faf02a","sha256:47197cb8f7765561cee8f8d327e852baaab651adc2afd7cd33b197ff968721ea"],"state_sha256":"4734a46aeb2f2778102551d3c335b34ef4ccbcab44045d10f66b20f4f4a2d992"}