{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:RL7CI6H3PIBW2XVVOZZIH3VO4M","short_pith_number":"pith:RL7CI6H3","canonical_record":{"source":{"id":"1706.03337","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-06-11T10:24:41Z","cross_cats_sorted":[],"title_canon_sha256":"7e15cd75c4b551259395f31c5550879078d3547c22a357bf4535a9560f370cfb","abstract_canon_sha256":"efa4c22c6a6d12876733130e1c69248fc505d2da21ee107b62da50ea0ca06411"},"schema_version":"1.0"},"canonical_sha256":"8afe2478fb7a036d5eb5767283eeaee301a5f5d12ea3a716dac1402fa189bd0a","source":{"kind":"arxiv","id":"1706.03337","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1706.03337","created_at":"2026-05-18T00:21:13Z"},{"alias_kind":"arxiv_version","alias_value":"1706.03337v1","created_at":"2026-05-18T00:21:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1706.03337","created_at":"2026-05-18T00:21:13Z"},{"alias_kind":"pith_short_12","alias_value":"RL7CI6H3PIBW","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_16","alias_value":"RL7CI6H3PIBW2XVV","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_8","alias_value":"RL7CI6H3","created_at":"2026-05-18T12:31:39Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:RL7CI6H3PIBW2XVVOZZIH3VO4M","target":"record","payload":{"canonical_record":{"source":{"id":"1706.03337","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-06-11T10:24:41Z","cross_cats_sorted":[],"title_canon_sha256":"7e15cd75c4b551259395f31c5550879078d3547c22a357bf4535a9560f370cfb","abstract_canon_sha256":"efa4c22c6a6d12876733130e1c69248fc505d2da21ee107b62da50ea0ca06411"},"schema_version":"1.0"},"canonical_sha256":"8afe2478fb7a036d5eb5767283eeaee301a5f5d12ea3a716dac1402fa189bd0a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:21:13.692758Z","signature_b64":"NpmjtNMZjJ68IltbrNfpxUxCJWvo4p0cABFFEpBafAiv+QBNkBNfgULrFvZYBsi7ErxVxBpsqX87/J6zi7SBBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"8afe2478fb7a036d5eb5767283eeaee301a5f5d12ea3a716dac1402fa189bd0a","last_reissued_at":"2026-05-18T00:21:13.692161Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:21:13.692161Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1706.03337","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:21:13Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"I6ieyStD/pA8GmilvMpsiK+EXn8rlsP9zOWTwJdyNcN3ooYCgE9LNEKzBGx6JUoHNGYYDfR+QyOBr9WlkRlkBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T03:47:41.405594Z"},"content_sha256":"63e3b97f9b2aad70902aa495e8caf536836d1c7ba87469440520d6a33143a8d1","schema_version":"1.0","event_id":"sha256:63e3b97f9b2aad70902aa495e8caf536836d1c7ba87469440520d6a33143a8d1"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:RL7CI6H3PIBW2XVVOZZIH3VO4M","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Effect of Grafting on Aggregation of Intrinsically Disordered Proteins","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Dino Osmanovic, Yitzhak Rabin","submitted_at":"2017-06-11T10:24:41Z","abstract_excerpt":"A significant part of the proteome is composed of intrinsically-disordered proteins (IDPs). These proteins do not fold into a well-defined structure and behave like ordinary polymers. In this work we consider IDPs which have the tendency to aggregate, model them as heteropolymers that contain a small number of associating monomers and use computer simulations in order to compare the aggregation of such IDPs that are grafted to a surface or free in solution. We then discuss how such grafting may affect the analysis of in-vitro experiments and could also be used to suppress harmful aggregation."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1706.03337","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:21:13Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6BHOQDco5RIchdadiFv1bR9OkHNkwCvRcwZcP70uJ9stdbcA94BmhS5bPZx7402rbFJxbsqzIDwe52IypPMAAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T03:47:41.405940Z"},"content_sha256":"6ee0353e767b14b368d7f526bfeecf58969d8fbc48e89bac0e555567d5bb95ac","schema_version":"1.0","event_id":"sha256:6ee0353e767b14b368d7f526bfeecf58969d8fbc48e89bac0e555567d5bb95ac"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/RL7CI6H3PIBW2XVVOZZIH3VO4M/bundle.json","state_url":"https://pith.science/pith/RL7CI6H3PIBW2XVVOZZIH3VO4M/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/RL7CI6H3PIBW2XVVOZZIH3VO4M/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T03:47:41Z","links":{"resolver":"https://pith.science/pith/RL7CI6H3PIBW2XVVOZZIH3VO4M","bundle":"https://pith.science/pith/RL7CI6H3PIBW2XVVOZZIH3VO4M/bundle.json","state":"https://pith.science/pith/RL7CI6H3PIBW2XVVOZZIH3VO4M/state.json","well_known_bundle":"https://pith.science/.well-known/pith/RL7CI6H3PIBW2XVVOZZIH3VO4M/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:RL7CI6H3PIBW2XVVOZZIH3VO4M","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"efa4c22c6a6d12876733130e1c69248fc505d2da21ee107b62da50ea0ca06411","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-06-11T10:24:41Z","title_canon_sha256":"7e15cd75c4b551259395f31c5550879078d3547c22a357bf4535a9560f370cfb"},"schema_version":"1.0","source":{"id":"1706.03337","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1706.03337","created_at":"2026-05-18T00:21:13Z"},{"alias_kind":"arxiv_version","alias_value":"1706.03337v1","created_at":"2026-05-18T00:21:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1706.03337","created_at":"2026-05-18T00:21:13Z"},{"alias_kind":"pith_short_12","alias_value":"RL7CI6H3PIBW","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_16","alias_value":"RL7CI6H3PIBW2XVV","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_8","alias_value":"RL7CI6H3","created_at":"2026-05-18T12:31:39Z"}],"graph_snapshots":[{"event_id":"sha256:6ee0353e767b14b368d7f526bfeecf58969d8fbc48e89bac0e555567d5bb95ac","target":"graph","created_at":"2026-05-18T00:21:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A significant part of the proteome is composed of intrinsically-disordered proteins (IDPs). These proteins do not fold into a well-defined structure and behave like ordinary polymers. In this work we consider IDPs which have the tendency to aggregate, model them as heteropolymers that contain a small number of associating monomers and use computer simulations in order to compare the aggregation of such IDPs that are grafted to a surface or free in solution. We then discuss how such grafting may affect the analysis of in-vitro experiments and could also be used to suppress harmful aggregation.","authors_text":"Dino Osmanovic, Yitzhak Rabin","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-06-11T10:24:41Z","title":"Effect of Grafting on Aggregation of Intrinsically Disordered Proteins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1706.03337","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:63e3b97f9b2aad70902aa495e8caf536836d1c7ba87469440520d6a33143a8d1","target":"record","created_at":"2026-05-18T00:21:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"efa4c22c6a6d12876733130e1c69248fc505d2da21ee107b62da50ea0ca06411","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-06-11T10:24:41Z","title_canon_sha256":"7e15cd75c4b551259395f31c5550879078d3547c22a357bf4535a9560f370cfb"},"schema_version":"1.0","source":{"id":"1706.03337","kind":"arxiv","version":1}},"canonical_sha256":"8afe2478fb7a036d5eb5767283eeaee301a5f5d12ea3a716dac1402fa189bd0a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"8afe2478fb7a036d5eb5767283eeaee301a5f5d12ea3a716dac1402fa189bd0a","first_computed_at":"2026-05-18T00:21:13.692161Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:21:13.692161Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"NpmjtNMZjJ68IltbrNfpxUxCJWvo4p0cABFFEpBafAiv+QBNkBNfgULrFvZYBsi7ErxVxBpsqX87/J6zi7SBBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:21:13.692758Z","signed_message":"canonical_sha256_bytes"},"source_id":"1706.03337","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:63e3b97f9b2aad70902aa495e8caf536836d1c7ba87469440520d6a33143a8d1","sha256:6ee0353e767b14b368d7f526bfeecf58969d8fbc48e89bac0e555567d5bb95ac"],"state_sha256":"972aafbcbc3078eed0513b94630a551aa34714a7a0c55d40f55d58566274bd52"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fdYo2de/2N4DHCTj3X58puKQvCJXtdwvPUvskpq7OtbpRkHpyifKiyi0/OvdQtigkgYLdmJyIClHmt1JgHUSCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T03:47:41.408076Z","bundle_sha256":"dbb722e3a304b943586bcd59480935608ccbdd7005defd740a3c88f1743d6297"}}