{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:RNAMDGDGNOXS4BAUBQLGI2OFDL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"09ec8a46dc291e78d2b6e3781cfd418cd1e73093ed586b3a8a35849f6efbee60","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.DS","submitted_at":"2017-06-13T19:35:40Z","title_canon_sha256":"1a07c045f74d98d6a5ebf9ec2df4ae9b73083b5feb34e705422bcfd1e5098235"},"schema_version":"1.0","source":{"id":"1706.04234","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1706.04234","created_at":"2026-05-18T00:42:23Z"},{"alias_kind":"arxiv_version","alias_value":"1706.04234v1","created_at":"2026-05-18T00:42:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1706.04234","created_at":"2026-05-18T00:42:23Z"},{"alias_kind":"pith_short_12","alias_value":"RNAMDGDGNOXS","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_16","alias_value":"RNAMDGDGNOXS4BAU","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_8","alias_value":"RNAMDGDG","created_at":"2026-05-18T12:31:39Z"}],"graph_snapshots":[{"event_id":"sha256:459c89796755e4eb08829abbd6508d52e8ffa4fa594dace9a41ba133283673ff","target":"graph","created_at":"2026-05-18T00:42:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We show how a graph algorithm for finding matching labeled paths in pairs of labeled directed graphs can be used to perform model validation for a class of dynamical systems including regulatory network models of relevance to systems biology. In particular, we extract a partial order of events describing local minima and local maxima of observed quantities from experimental time-series data from which we produce a labeled directed graph we call the pattern graph for which every path from root to leaf corresponds to a plausible sequence of events. We then consider the regulatory network model, ","authors_text":"Bree Cummins, Konstantin Mischaikow, Shaun Harker, Tomas Gedeon","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.DS","submitted_at":"2017-06-13T19:35:40Z","title":"Model rejection and parameter reduction via time series"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1706.04234","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:426f5a9589774ef4eb2b3cf46794c971d9ab3640447b79ba7df97d28d1276927","target":"record","created_at":"2026-05-18T00:42:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"09ec8a46dc291e78d2b6e3781cfd418cd1e73093ed586b3a8a35849f6efbee60","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.DS","submitted_at":"2017-06-13T19:35:40Z","title_canon_sha256":"1a07c045f74d98d6a5ebf9ec2df4ae9b73083b5feb34e705422bcfd1e5098235"},"schema_version":"1.0","source":{"id":"1706.04234","kind":"arxiv","version":1}},"canonical_sha256":"8b40c198666baf2e04140c166469c51acacca0732938d09a02ae4fab6b1e3167","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"8b40c198666baf2e04140c166469c51acacca0732938d09a02ae4fab6b1e3167","first_computed_at":"2026-05-18T00:42:23.196576Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:42:23.196576Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bHQ3NjhOAkue4Xk0sKVjDuY+egcrmb0WXfTCMA4W2K1zZ1px+6L1OslhygwUUKcYrZtaQRutASmmO45xgeWrCw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:42:23.197044Z","signed_message":"canonical_sha256_bytes"},"source_id":"1706.04234","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:426f5a9589774ef4eb2b3cf46794c971d9ab3640447b79ba7df97d28d1276927","sha256:459c89796755e4eb08829abbd6508d52e8ffa4fa594dace9a41ba133283673ff"],"state_sha256":"472f8c9dc061e3a794d8746a49c3a86b0ff93bb136f816f48fa01b9357805908"}