{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:ROXZAVT4KGC2WSLRH4NJE76OJR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d675cbabb415ec94a0628c6ec24d136ad64f12a2d03ee9d2032b9d229041f7e5","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-06-23T01:33:19Z","title_canon_sha256":"6942320aa4fb5dead4321616dbb1d7536af6ee9a64eb7dfd3fbb653b40dc4486"},"schema_version":"1.0","source":{"id":"2506.18229","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.18229","created_at":"2026-07-05T11:26:53Z"},{"alias_kind":"arxiv_version","alias_value":"2506.18229v2","created_at":"2026-07-05T11:26:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.18229","created_at":"2026-07-05T11:26:53Z"},{"alias_kind":"pith_short_12","alias_value":"ROXZAVT4KGC2","created_at":"2026-07-05T11:26:53Z"},{"alias_kind":"pith_short_16","alias_value":"ROXZAVT4KGC2WSLR","created_at":"2026-07-05T11:26:53Z"},{"alias_kind":"pith_short_8","alias_value":"ROXZAVT4","created_at":"2026-07-05T11:26:53Z"}],"graph_snapshots":[{"event_id":"sha256:873c07fdca881f76711f1c6e02a344cac959016c2ad80e4641188d805bc6d012","target":"graph","created_at":"2026-07-05T11:26:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.18229/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Time-dependent diffusion MRI (dMRI) with single diffusion encoding (SDE) probes water dynamics in biological tissues, but signal interpretation depends on microstructure. While prior work focused on restricted/hindered diffusion and membrane permeation, diffusion-mediated exchange between dendritic shafts and spines in gray matter (GM) remains understudied. We hypothesize that impermeable spiny dendrites produce time-dependent SDE signals mimicking permeative exchange and investigate how spine density biases exchange time estimates.\n  Using Monte Carlo simulations and narrow escape theory, we ","authors_text":"Arthur Chakwizira, Kadir \\c{S}im\\c{s}ek, Marco Palombo, Markus Nilsson","cross_cats":["physics.bio-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-06-23T01:33:19Z","title":"The role of dendritic spines in water exchange measurements with diffusion MRI: Time-Dependent Single Diffusion Encoding MRI"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.18229","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3946a2d63e085372e6d5d0c5c1413913cbfb6a4aea8cacadf34943c08cf9f38e","target":"record","created_at":"2026-07-05T11:26:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d675cbabb415ec94a0628c6ec24d136ad64f12a2d03ee9d2032b9d229041f7e5","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-06-23T01:33:19Z","title_canon_sha256":"6942320aa4fb5dead4321616dbb1d7536af6ee9a64eb7dfd3fbb653b40dc4486"},"schema_version":"1.0","source":{"id":"2506.18229","kind":"arxiv","version":2}},"canonical_sha256":"8baf90567c5185ab49713f1a927fce4c58fcb0e50c1cfb52971c3e3dad92ae48","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"8baf90567c5185ab49713f1a927fce4c58fcb0e50c1cfb52971c3e3dad92ae48","first_computed_at":"2026-07-05T11:26:53.452776Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:26:53.452776Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"A+DbCtuPvbeLPJS6mTT9sKoCVvsKj1NQ9cx83NkLlsa0MV7swQlJoUqFwcZN+CV6P5HeIX8lAuKVYdS6m5trDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:26:53.453276Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.18229","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3946a2d63e085372e6d5d0c5c1413913cbfb6a4aea8cacadf34943c08cf9f38e","sha256:873c07fdca881f76711f1c6e02a344cac959016c2ad80e4641188d805bc6d012"],"state_sha256":"43a0921fb575986edb3fc21cb75e8bcd482f91afcb60f8d4feb6ffb0b2424185"}