{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2013:RT5O2QG2AG5P47PUC7S5ACU2JY","short_pith_number":"pith:RT5O2QG2","schema_version":"1.0","canonical_sha256":"8cfaed40da01bafe7df417e5d00a9a4e13c498be4eb3a54035611b1ecc4c4b8b","source":{"kind":"arxiv","id":"1308.1453","version":1},"attestation_state":"computed","paper":{"title":"The molecular mechanism of a cis-regulatory adaptation in yeast","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.PE","authors_text":"Cameron Henry, Erin M. Green, Hunter B. Fraser, Jessica Chang, Lucia Lam, Michael S. Kobor, Ryosuke Kita, Xiaoli Hu, Yiqi Zhou","submitted_at":"2013-08-07T00:42:01Z","abstract_excerpt":"Despite recent advances in our ability to detect adaptive evolution involving the cis-regulation of gene expression, our knowledge of the molecular mechanisms underlying these adaptations has lagged far behind. Across all model organisms the causal mutations have been discovered for only a handful of gene expression adaptations, and even for these, mechanistic details (e.g. the trans-regulatory factors involved) have not been determined. We previously reported a polygenic gene expression adaptation involving down-regulation of the ergosterol biosynthesis pathway in the budding yeast Saccharomy"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1308.1453","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-08-07T00:42:01Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"a8f51bfff48bd4291d13c7e650d45c90844e0dbdb714ead0ed1f00acda5a1795","abstract_canon_sha256":"a070206407c7e321197a37bf525665a8e616a2dd246c34de5ca5676e7294e109"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:16:38.018969Z","signature_b64":"AgVwuC5AaB92eYozhezFM+tPffkoNk3B7a9mXksPXZJlgr1QBAXegNNOa4+mJ8GR43wEefilbuZ41uTEz2GZBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"8cfaed40da01bafe7df417e5d00a9a4e13c498be4eb3a54035611b1ecc4c4b8b","last_reissued_at":"2026-05-18T03:16:38.018556Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:16:38.018556Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"The molecular mechanism of a cis-regulatory adaptation in yeast","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.PE","authors_text":"Cameron Henry, Erin M. Green, Hunter B. Fraser, Jessica Chang, Lucia Lam, Michael S. Kobor, Ryosuke Kita, Xiaoli Hu, Yiqi Zhou","submitted_at":"2013-08-07T00:42:01Z","abstract_excerpt":"Despite recent advances in our ability to detect adaptive evolution involving the cis-regulation of gene expression, our knowledge of the molecular mechanisms underlying these adaptations has lagged far behind. Across all model organisms the causal mutations have been discovered for only a handful of gene expression adaptations, and even for these, mechanistic details (e.g. the trans-regulatory factors involved) have not been determined. We previously reported a polygenic gene expression adaptation involving down-regulation of the ergosterol biosynthesis pathway in the budding yeast Saccharomy"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1308.1453","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1308.1453","created_at":"2026-05-18T03:16:38.018612+00:00"},{"alias_kind":"arxiv_version","alias_value":"1308.1453v1","created_at":"2026-05-18T03:16:38.018612+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1308.1453","created_at":"2026-05-18T03:16:38.018612+00:00"},{"alias_kind":"pith_short_12","alias_value":"RT5O2QG2AG5P","created_at":"2026-05-18T12:27:59.945178+00:00"},{"alias_kind":"pith_short_16","alias_value":"RT5O2QG2AG5P47PU","created_at":"2026-05-18T12:27:59.945178+00:00"},{"alias_kind":"pith_short_8","alias_value":"RT5O2QG2","created_at":"2026-05-18T12:27:59.945178+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY","json":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY.json","graph_json":"https://pith.science/api/pith-number/RT5O2QG2AG5P47PUC7S5ACU2JY/graph.json","events_json":"https://pith.science/api/pith-number/RT5O2QG2AG5P47PUC7S5ACU2JY/events.json","paper":"https://pith.science/paper/RT5O2QG2"},"agent_actions":{"view_html":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY","download_json":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY.json","view_paper":"https://pith.science/paper/RT5O2QG2","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1308.1453&json=true","fetch_graph":"https://pith.science/api/pith-number/RT5O2QG2AG5P47PUC7S5ACU2JY/graph.json","fetch_events":"https://pith.science/api/pith-number/RT5O2QG2AG5P47PUC7S5ACU2JY/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY/action/timestamp_anchor","attest_storage":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY/action/storage_attestation","attest_author":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY/action/author_attestation","sign_citation":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY/action/citation_signature","submit_replication":"https://pith.science/pith/RT5O2QG2AG5P47PUC7S5ACU2JY/action/replication_record"}},"created_at":"2026-05-18T03:16:38.018612+00:00","updated_at":"2026-05-18T03:16:38.018612+00:00"}