{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:RV2BPQXPFZ7QENMK7C6WQ6CCNF","short_pith_number":"pith:RV2BPQXP","canonical_record":{"source":{"id":"1212.1096","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2012-12-05T17:00:52Z","cross_cats_sorted":[],"title_canon_sha256":"518c27f77aa7c816dadd87e3abf06649186ce164bdc8aee4d39fa27a4ca9d0c2","abstract_canon_sha256":"6b9867aa6c0c1b5dbe213a9edd97a46b13eb53f2246fd5c3c5b2938ad4930a3e"},"schema_version":"1.0"},"canonical_sha256":"8d7417c2ef2e7f02358af8bd68784269653e3f15ee23e42e4ebecde0d09738a4","source":{"kind":"arxiv","id":"1212.1096","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1212.1096","created_at":"2026-05-18T03:39:05Z"},{"alias_kind":"arxiv_version","alias_value":"1212.1096v1","created_at":"2026-05-18T03:39:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1212.1096","created_at":"2026-05-18T03:39:05Z"},{"alias_kind":"pith_short_12","alias_value":"RV2BPQXPFZ7Q","created_at":"2026-05-18T12:27:20Z"},{"alias_kind":"pith_short_16","alias_value":"RV2BPQXPFZ7QENMK","created_at":"2026-05-18T12:27:20Z"},{"alias_kind":"pith_short_8","alias_value":"RV2BPQXP","created_at":"2026-05-18T12:27:20Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:RV2BPQXPFZ7QENMK7C6WQ6CCNF","target":"record","payload":{"canonical_record":{"source":{"id":"1212.1096","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2012-12-05T17:00:52Z","cross_cats_sorted":[],"title_canon_sha256":"518c27f77aa7c816dadd87e3abf06649186ce164bdc8aee4d39fa27a4ca9d0c2","abstract_canon_sha256":"6b9867aa6c0c1b5dbe213a9edd97a46b13eb53f2246fd5c3c5b2938ad4930a3e"},"schema_version":"1.0"},"canonical_sha256":"8d7417c2ef2e7f02358af8bd68784269653e3f15ee23e42e4ebecde0d09738a4","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:39:05.874624Z","signature_b64":"riSpWIrqjkK2in6gcTrvRcwAl948L5PhZKrziOy6Mpvbhvh39oNz87+ZrEOIGIyTwb/mRY0W2dbxnLATQ3KMAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"8d7417c2ef2e7f02358af8bd68784269653e3f15ee23e42e4ebecde0d09738a4","last_reissued_at":"2026-05-18T03:39:05.874000Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:39:05.874000Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1212.1096","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:39:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"yFIeP4dQoMWRHXP5YtbU5oFUM3aJjmJijyO26FqpDmKNtlFfL/IZrmt6a9I8hai29zZOV1moTZSHC97ls106DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T06:31:17.566163Z"},"content_sha256":"c42b396a8907552749d0ed394f61ee59631b16a4bd1e6af11f360bf27a494b4e","schema_version":"1.0","event_id":"sha256:c42b396a8907552749d0ed394f61ee59631b16a4bd1e6af11f360bf27a494b4e"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:RV2BPQXPFZ7QENMK7C6WQ6CCNF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Computational modeling of spike generation in serotonergic neurons of the dorsal raphe nucleu","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Henry C. Tuckwell, Nicholas J. Penington","submitted_at":"2012-12-05T17:00:52Z","abstract_excerpt":"We consider here a single-compartment model of these neurons which is capable of describing many of the known features of spike generation, particularly the slow rhythmic pacemaking activity often observed in these cells in a variety of species. Included in the model are ten kinds of voltage dependent ion channels as well as calcium-dependent potassium current. Calcium dynamics includes buffering and pumping. In sections 3-9, each component is considered in detail and parameters estimated from voltage clamp data where possible. In the next two sections simplified versions of some components ar"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1212.1096","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:39:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5HewFbL14JViiwsCX+QSsFAWDaKg1/x93zvJ3EcZVFJeIMfxRyEl7Enc+S0xD3zrxDMa86lTq05RccfRPrZkCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T06:31:17.566719Z"},"content_sha256":"b1565319d4388cb197875e8e65c144d61321c5285e381b775ee632163325475e","schema_version":"1.0","event_id":"sha256:b1565319d4388cb197875e8e65c144d61321c5285e381b775ee632163325475e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/RV2BPQXPFZ7QENMK7C6WQ6CCNF/bundle.json","state_url":"https://pith.science/pith/RV2BPQXPFZ7QENMK7C6WQ6CCNF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/RV2BPQXPFZ7QENMK7C6WQ6CCNF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-05T06:31:17Z","links":{"resolver":"https://pith.science/pith/RV2BPQXPFZ7QENMK7C6WQ6CCNF","bundle":"https://pith.science/pith/RV2BPQXPFZ7QENMK7C6WQ6CCNF/bundle.json","state":"https://pith.science/pith/RV2BPQXPFZ7QENMK7C6WQ6CCNF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/RV2BPQXPFZ7QENMK7C6WQ6CCNF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:RV2BPQXPFZ7QENMK7C6WQ6CCNF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6b9867aa6c0c1b5dbe213a9edd97a46b13eb53f2246fd5c3c5b2938ad4930a3e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2012-12-05T17:00:52Z","title_canon_sha256":"518c27f77aa7c816dadd87e3abf06649186ce164bdc8aee4d39fa27a4ca9d0c2"},"schema_version":"1.0","source":{"id":"1212.1096","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1212.1096","created_at":"2026-05-18T03:39:05Z"},{"alias_kind":"arxiv_version","alias_value":"1212.1096v1","created_at":"2026-05-18T03:39:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1212.1096","created_at":"2026-05-18T03:39:05Z"},{"alias_kind":"pith_short_12","alias_value":"RV2BPQXPFZ7Q","created_at":"2026-05-18T12:27:20Z"},{"alias_kind":"pith_short_16","alias_value":"RV2BPQXPFZ7QENMK","created_at":"2026-05-18T12:27:20Z"},{"alias_kind":"pith_short_8","alias_value":"RV2BPQXP","created_at":"2026-05-18T12:27:20Z"}],"graph_snapshots":[{"event_id":"sha256:b1565319d4388cb197875e8e65c144d61321c5285e381b775ee632163325475e","target":"graph","created_at":"2026-05-18T03:39:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We consider here a single-compartment model of these neurons which is capable of describing many of the known features of spike generation, particularly the slow rhythmic pacemaking activity often observed in these cells in a variety of species. Included in the model are ten kinds of voltage dependent ion channels as well as calcium-dependent potassium current. Calcium dynamics includes buffering and pumping. In sections 3-9, each component is considered in detail and parameters estimated from voltage clamp data where possible. In the next two sections simplified versions of some components ar","authors_text":"Henry C. Tuckwell, Nicholas J. Penington","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2012-12-05T17:00:52Z","title":"Computational modeling of spike generation in serotonergic neurons of the dorsal raphe nucleu"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1212.1096","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c42b396a8907552749d0ed394f61ee59631b16a4bd1e6af11f360bf27a494b4e","target":"record","created_at":"2026-05-18T03:39:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6b9867aa6c0c1b5dbe213a9edd97a46b13eb53f2246fd5c3c5b2938ad4930a3e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2012-12-05T17:00:52Z","title_canon_sha256":"518c27f77aa7c816dadd87e3abf06649186ce164bdc8aee4d39fa27a4ca9d0c2"},"schema_version":"1.0","source":{"id":"1212.1096","kind":"arxiv","version":1}},"canonical_sha256":"8d7417c2ef2e7f02358af8bd68784269653e3f15ee23e42e4ebecde0d09738a4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"8d7417c2ef2e7f02358af8bd68784269653e3f15ee23e42e4ebecde0d09738a4","first_computed_at":"2026-05-18T03:39:05.874000Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:39:05.874000Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"riSpWIrqjkK2in6gcTrvRcwAl948L5PhZKrziOy6Mpvbhvh39oNz87+ZrEOIGIyTwb/mRY0W2dbxnLATQ3KMAA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:39:05.874624Z","signed_message":"canonical_sha256_bytes"},"source_id":"1212.1096","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c42b396a8907552749d0ed394f61ee59631b16a4bd1e6af11f360bf27a494b4e","sha256:b1565319d4388cb197875e8e65c144d61321c5285e381b775ee632163325475e"],"state_sha256":"5be5e378f351def1f605fca985612edbd7c7492e5ff12e3300615892414c997e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"makgqA3pKnUIvEDSBU0LuSHIn0jtqRS7IvwjeccOo46VbiChDnhYT/SscR0701vNps61HRPiTe2Las2nq0J2Aw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-05T06:31:17.569366Z","bundle_sha256":"05e04764b4836bb4765bcd6d6e836d630c1f0a41ef45c14b9617e587a58af07f"}}