{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2021:S6RSHP5RYHRDIYKWEL7SFL7Y4O","short_pith_number":"pith:S6RSHP5R","schema_version":"1.0","canonical_sha256":"97a323bfb1c1e234615622ff22aff8e3a91499694ccbeb5876ec640933053a33","source":{"kind":"arxiv","id":"2108.10018","version":1},"attestation_state":"computed","paper":{"title":"Mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.ST","q-bio.QM","stat.TH"],"primary_cat":"q-bio.PE","authors_text":"\\'Alvaro Olivera-Nappa, Andr\\'es E. Castillo, David Medina-Ortiz, Emil N. Iftekhar, Jonas Dehning, Jorge Fern\\'andez, Karen Mujica, Karen Y. Or\\'ostica, Paulo C. Covarrubias, Ricardo A. Verdugo, Sebastian B. Mohr, Sebastian Contreras, Simon Bauer, Soledad Ulloa, Viola Priesemann","submitted_at":"2021-08-23T09:10:49Z","abstract_excerpt":"The emergence of SARS-CoV-2 variants of concern endangers the long-term control of COVID-19, especially in countries with limited genomic surveillance. In this work, we explored genomic drivers of contagion in Chile. We sequenced 3443 SARS-CoV-2 genomes collected between January and July 2021, where the Gamma (P.1), Lambda (C.37), Alpha (B.1.1.7), B.1.1.348, and B.1.1 lineages were predominant. Using a Bayesian model tailored for limited genomic surveillance, we found that Lambda and Gamma variants' reproduction numbers were about 5% and 16% larger than Alpha's, respectively. We observed an ov"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2108.10018","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2021-08-23T09:10:49Z","cross_cats_sorted":["math.ST","q-bio.QM","stat.TH"],"title_canon_sha256":"4b8c0ab2803461f9ff3fd32aa92b4b3d7d2c6e875868feafe1c0d4f23d0f6ecf","abstract_canon_sha256":"dd75ba5ddb845eb058436d679f8a4a2b158e0216faaf00c1702d10ceefa3e282"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:08:39.008721Z","signature_b64":"1NbiqmjI5URr+8bfFlwUPkmMAEpPGgobbs6Vh+93/TgROVo2al9jr+Tv0i41HoScsI/GWoEJtfFcNlvd73GEAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"97a323bfb1c1e234615622ff22aff8e3a91499694ccbeb5876ec640933053a33","last_reissued_at":"2026-07-05T03:08:39.008333Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:08:39.008333Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.ST","q-bio.QM","stat.TH"],"primary_cat":"q-bio.PE","authors_text":"\\'Alvaro Olivera-Nappa, Andr\\'es E. Castillo, David Medina-Ortiz, Emil N. Iftekhar, Jonas Dehning, Jorge Fern\\'andez, Karen Mujica, Karen Y. Or\\'ostica, Paulo C. Covarrubias, Ricardo A. Verdugo, Sebastian B. Mohr, Sebastian Contreras, Simon Bauer, Soledad Ulloa, Viola Priesemann","submitted_at":"2021-08-23T09:10:49Z","abstract_excerpt":"The emergence of SARS-CoV-2 variants of concern endangers the long-term control of COVID-19, especially in countries with limited genomic surveillance. In this work, we explored genomic drivers of contagion in Chile. We sequenced 3443 SARS-CoV-2 genomes collected between January and July 2021, where the Gamma (P.1), Lambda (C.37), Alpha (B.1.1.7), B.1.1.348, and B.1.1 lineages were predominant. Using a Bayesian model tailored for limited genomic surveillance, we found that Lambda and Gamma variants' reproduction numbers were about 5% and 16% larger than Alpha's, respectively. We observed an ov"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2108.10018","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2108.10018/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2108.10018","created_at":"2026-07-05T03:08:39.008387+00:00"},{"alias_kind":"arxiv_version","alias_value":"2108.10018v1","created_at":"2026-07-05T03:08:39.008387+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2108.10018","created_at":"2026-07-05T03:08:39.008387+00:00"},{"alias_kind":"pith_short_12","alias_value":"S6RSHP5RYHRD","created_at":"2026-07-05T03:08:39.008387+00:00"},{"alias_kind":"pith_short_16","alias_value":"S6RSHP5RYHRDIYKW","created_at":"2026-07-05T03:08:39.008387+00:00"},{"alias_kind":"pith_short_8","alias_value":"S6RSHP5R","created_at":"2026-07-05T03:08:39.008387+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O","json":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O.json","graph_json":"https://pith.science/api/pith-number/S6RSHP5RYHRDIYKWEL7SFL7Y4O/graph.json","events_json":"https://pith.science/api/pith-number/S6RSHP5RYHRDIYKWEL7SFL7Y4O/events.json","paper":"https://pith.science/paper/S6RSHP5R"},"agent_actions":{"view_html":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O","download_json":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O.json","view_paper":"https://pith.science/paper/S6RSHP5R","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2108.10018&json=true","fetch_graph":"https://pith.science/api/pith-number/S6RSHP5RYHRDIYKWEL7SFL7Y4O/graph.json","fetch_events":"https://pith.science/api/pith-number/S6RSHP5RYHRDIYKWEL7SFL7Y4O/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O/action/timestamp_anchor","attest_storage":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O/action/storage_attestation","attest_author":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O/action/author_attestation","sign_citation":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O/action/citation_signature","submit_replication":"https://pith.science/pith/S6RSHP5RYHRDIYKWEL7SFL7Y4O/action/replication_record"}},"created_at":"2026-07-05T03:08:39.008387+00:00","updated_at":"2026-07-05T03:08:39.008387+00:00"}