{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:SAHDG77LEYVYV46TBPSK5GAR3E","short_pith_number":"pith:SAHDG77L","canonical_record":{"source":{"id":"1609.06843","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-22T07:36:28Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"30f2cfce346c544c6da022b5b1e98346cd71fe42d93334966c514ad01792731e","abstract_canon_sha256":"7cc7b9fc66616e2c88a30122e940e094147ca4b78a7fe0a64589a2d87f4338f4"},"schema_version":"1.0"},"canonical_sha256":"900e337feb262b8af3d30be4ae9811d93f518942d887ed121466598636383abd","source":{"kind":"arxiv","id":"1609.06843","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1609.06843","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"arxiv_version","alias_value":"1609.06843v1","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.06843","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"pith_short_12","alias_value":"SAHDG77LEYVY","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_16","alias_value":"SAHDG77LEYVYV46T","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_8","alias_value":"SAHDG77L","created_at":"2026-05-18T12:30:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:SAHDG77LEYVYV46TBPSK5GAR3E","target":"record","payload":{"canonical_record":{"source":{"id":"1609.06843","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-22T07:36:28Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"30f2cfce346c544c6da022b5b1e98346cd71fe42d93334966c514ad01792731e","abstract_canon_sha256":"7cc7b9fc66616e2c88a30122e940e094147ca4b78a7fe0a64589a2d87f4338f4"},"schema_version":"1.0"},"canonical_sha256":"900e337feb262b8af3d30be4ae9811d93f518942d887ed121466598636383abd","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:04:04.990427Z","signature_b64":"D3dwUhi0BFYrWwgVVtVPI+lJ9/koFUZ4AZtV5xkAi372zq9uXiJJ1FJGpHwPun4T/SIi6j6zk783hj09jbvfDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"900e337feb262b8af3d30be4ae9811d93f518942d887ed121466598636383abd","last_reissued_at":"2026-05-18T01:04:04.989890Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:04:04.989890Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1609.06843","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:04:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"r9SYqYLzQipSSnLtz3/KnbdTo6SuMJrw5h9yCGeyCwZqMeDQvZR9xbim7/fRIdGhhfrWrX7Y3I4KmDJk/DEgCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T00:25:09.423602Z"},"content_sha256":"6e72dbcddc90fc95f87ba2166ad99056ffb41432c2b5a9fd99d09e8ef332685f","schema_version":"1.0","event_id":"sha256:6e72dbcddc90fc95f87ba2166ad99056ffb41432c2b5a9fd99d09e8ef332685f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:SAHDG77LEYVYV46TBPSK5GAR3E","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Fluctuations in protein aggregation: Design of preclinical screening for early diagnosis of neurodegenerative disease","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.QM","authors_text":"Alessandro Taloni, Alexander K. Buell, Caterina A. M. La Porta, Giulio Costantini, Stefano Zapperi, Zoe Budrikis","submitted_at":"2016-09-22T07:36:28Z","abstract_excerpt":"Autocatalytic fibril nucleation has recently been proposed to be a determining factor for the spread of neurodegenerative diseases, but the same process could also be exploited to amplify minute quantities of protein aggregates in a diagnostic context. Recent advances in microfluidic technology allow analysis of protein aggregation in micron-scale samples potentially enabling such diagnostic approaches, but the theoretical foundations for the analysis and interpretation of such data are so far lacking. Here we study computationally the onset of protein aggregation in small volumes and show tha"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.06843","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:04:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"yn0w/iZ16BABcY/BUl3R62TBHV2/HYeQUP7Y9Jt6pUskVpgcmXeAgKIo7DANEgInhjVI/Mlg0nG6nCQxOsi0Dg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T00:25:09.423995Z"},"content_sha256":"89cd284cd94ae15021d2457b85ee4280b9bd7a487c3d7e225985bc4606468180","schema_version":"1.0","event_id":"sha256:89cd284cd94ae15021d2457b85ee4280b9bd7a487c3d7e225985bc4606468180"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/SAHDG77LEYVYV46TBPSK5GAR3E/bundle.json","state_url":"https://pith.science/pith/SAHDG77LEYVYV46TBPSK5GAR3E/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/SAHDG77LEYVYV46TBPSK5GAR3E/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T00:25:09Z","links":{"resolver":"https://pith.science/pith/SAHDG77LEYVYV46TBPSK5GAR3E","bundle":"https://pith.science/pith/SAHDG77LEYVYV46TBPSK5GAR3E/bundle.json","state":"https://pith.science/pith/SAHDG77LEYVYV46TBPSK5GAR3E/state.json","well_known_bundle":"https://pith.science/.well-known/pith/SAHDG77LEYVYV46TBPSK5GAR3E/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:SAHDG77LEYVYV46TBPSK5GAR3E","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7cc7b9fc66616e2c88a30122e940e094147ca4b78a7fe0a64589a2d87f4338f4","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-22T07:36:28Z","title_canon_sha256":"30f2cfce346c544c6da022b5b1e98346cd71fe42d93334966c514ad01792731e"},"schema_version":"1.0","source":{"id":"1609.06843","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1609.06843","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"arxiv_version","alias_value":"1609.06843v1","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.06843","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"pith_short_12","alias_value":"SAHDG77LEYVY","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_16","alias_value":"SAHDG77LEYVYV46T","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_8","alias_value":"SAHDG77L","created_at":"2026-05-18T12:30:44Z"}],"graph_snapshots":[{"event_id":"sha256:89cd284cd94ae15021d2457b85ee4280b9bd7a487c3d7e225985bc4606468180","target":"graph","created_at":"2026-05-18T01:04:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Autocatalytic fibril nucleation has recently been proposed to be a determining factor for the spread of neurodegenerative diseases, but the same process could also be exploited to amplify minute quantities of protein aggregates in a diagnostic context. Recent advances in microfluidic technology allow analysis of protein aggregation in micron-scale samples potentially enabling such diagnostic approaches, but the theoretical foundations for the analysis and interpretation of such data are so far lacking. Here we study computationally the onset of protein aggregation in small volumes and show tha","authors_text":"Alessandro Taloni, Alexander K. Buell, Caterina A. M. La Porta, Giulio Costantini, Stefano Zapperi, Zoe Budrikis","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-22T07:36:28Z","title":"Fluctuations in protein aggregation: Design of preclinical screening for early diagnosis of neurodegenerative disease"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.06843","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6e72dbcddc90fc95f87ba2166ad99056ffb41432c2b5a9fd99d09e8ef332685f","target":"record","created_at":"2026-05-18T01:04:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7cc7b9fc66616e2c88a30122e940e094147ca4b78a7fe0a64589a2d87f4338f4","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-09-22T07:36:28Z","title_canon_sha256":"30f2cfce346c544c6da022b5b1e98346cd71fe42d93334966c514ad01792731e"},"schema_version":"1.0","source":{"id":"1609.06843","kind":"arxiv","version":1}},"canonical_sha256":"900e337feb262b8af3d30be4ae9811d93f518942d887ed121466598636383abd","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"900e337feb262b8af3d30be4ae9811d93f518942d887ed121466598636383abd","first_computed_at":"2026-05-18T01:04:04.989890Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:04:04.989890Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"D3dwUhi0BFYrWwgVVtVPI+lJ9/koFUZ4AZtV5xkAi372zq9uXiJJ1FJGpHwPun4T/SIi6j6zk783hj09jbvfDg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:04:04.990427Z","signed_message":"canonical_sha256_bytes"},"source_id":"1609.06843","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6e72dbcddc90fc95f87ba2166ad99056ffb41432c2b5a9fd99d09e8ef332685f","sha256:89cd284cd94ae15021d2457b85ee4280b9bd7a487c3d7e225985bc4606468180"],"state_sha256":"9bd86521555fbc6f4b0f0a833fb7f6359a27622a7db8b0c55044f36f5f72ebda"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"x57WTz2WFm5ybdHPc/EOtBiV4mG12QYe5TrHElXVmo+oyjcyb4GQ+mbWxUpMKvgzK6PwWfiiXJ+DCWCtVJ5ZBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T00:25:09.427343Z","bundle_sha256":"30eed41c0d6f3526ae833b65817b2b55ea5485f2ace562c9641bd7fa8b0fd97e"}}