{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:SAL6YOV77M4I5QTU5T6XYDYMYD","short_pith_number":"pith:SAL6YOV7","canonical_record":{"source":{"id":"2503.15745","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-03-19T23:26:32Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"5d1630f9d67ac6cbeff76adb4fb2d562334396a5ed187c1ca5bdaa37b4e74008","abstract_canon_sha256":"29cce94e45c9f9ac87785586c90b519c473a88c10c1bb32327892f1f91bf721e"},"schema_version":"1.0"},"canonical_sha256":"9017ec3abffb388ec274ecfd7c0f0cc0d16b9dd63cb45d0ad125bb16c4f5c019","source":{"kind":"arxiv","id":"2503.15745","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2503.15745","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"arxiv_version","alias_value":"2503.15745v2","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2503.15745","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"pith_short_12","alias_value":"SAL6YOV77M4I","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"pith_short_16","alias_value":"SAL6YOV77M4I5QTU","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"pith_short_8","alias_value":"SAL6YOV7","created_at":"2026-07-05T12:04:14Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:SAL6YOV77M4I5QTU5T6XYDYMYD","target":"record","payload":{"canonical_record":{"source":{"id":"2503.15745","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-03-19T23:26:32Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"5d1630f9d67ac6cbeff76adb4fb2d562334396a5ed187c1ca5bdaa37b4e74008","abstract_canon_sha256":"29cce94e45c9f9ac87785586c90b519c473a88c10c1bb32327892f1f91bf721e"},"schema_version":"1.0"},"canonical_sha256":"9017ec3abffb388ec274ecfd7c0f0cc0d16b9dd63cb45d0ad125bb16c4f5c019","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T12:04:14.321729Z","signature_b64":"3vAkhvswXE+vC+LAuf7yRjsgCaQgnaApR4QODrCHQtuNqb41X8RSUGovFR+xVHSyzXABnhaKDjAdjL/rnJLfDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9017ec3abffb388ec274ecfd7c0f0cc0d16b9dd63cb45d0ad125bb16c4f5c019","last_reissued_at":"2026-07-05T12:04:14.321226Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T12:04:14.321226Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2503.15745","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T12:04:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WEO91nvEp401b/E03MS8ZHmTgKm6vguZra2kbq0AYBJTt13ky07Qmmhw9aASlyQ7KT9qLqY9TP3sdshf3np3Bg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T03:33:30.981386Z"},"content_sha256":"192fbf53dd1bfeb766d2a4d775b6be3ccd213f8566688b9ffd365b94252573f5","schema_version":"1.0","event_id":"sha256:192fbf53dd1bfeb766d2a4d775b6be3ccd213f8566688b9ffd365b94252573f5"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:SAL6YOV77M4I5QTU5T6XYDYMYD","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Statistical Inference for Heterogeneous Treatment Effect with Right-censored Data from Synthesizing Randomized Clinical Trials and Real-world Data","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"stat.ME","authors_text":"Guangcai Mao, Shu Yang, Xiaofei Wang","submitted_at":"2025-03-19T23:26:32Z","abstract_excerpt":"The heterogeneous treatment effect plays a crucial role in precision medicine.There is evidence that real-world data, even subject to biases, can be employed as supplementary evidence for randomized clinical trials to improve the statistical efficiency of the heterogeneous treatment effect estimation. In this paper, for survival data with right censoring, we consider estimating the heterogeneous treatment effect, defined as the difference of the treatment-specific conditional restricted mean survival times given covariates, by synthesizing evidence from randomized clinical trials and the real-"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2503.15745","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2503.15745/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T12:04:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JDY0TipgrLjQzmUYBI4oVZu1qDtqhpy/HJaSGFUMhFlYoMy215ymRf1Fwhu4i2Igtxrgj185tDxlZHcWoWOVDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T03:33:30.982124Z"},"content_sha256":"a25514928fefdb62498b9ecb7073fba49818506d9fc5a36067c4b5472a51b218","schema_version":"1.0","event_id":"sha256:a25514928fefdb62498b9ecb7073fba49818506d9fc5a36067c4b5472a51b218"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/SAL6YOV77M4I5QTU5T6XYDYMYD/bundle.json","state_url":"https://pith.science/pith/SAL6YOV77M4I5QTU5T6XYDYMYD/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/SAL6YOV77M4I5QTU5T6XYDYMYD/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-06T03:33:30Z","links":{"resolver":"https://pith.science/pith/SAL6YOV77M4I5QTU5T6XYDYMYD","bundle":"https://pith.science/pith/SAL6YOV77M4I5QTU5T6XYDYMYD/bundle.json","state":"https://pith.science/pith/SAL6YOV77M4I5QTU5T6XYDYMYD/state.json","well_known_bundle":"https://pith.science/.well-known/pith/SAL6YOV77M4I5QTU5T6XYDYMYD/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:SAL6YOV77M4I5QTU5T6XYDYMYD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"29cce94e45c9f9ac87785586c90b519c473a88c10c1bb32327892f1f91bf721e","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-03-19T23:26:32Z","title_canon_sha256":"5d1630f9d67ac6cbeff76adb4fb2d562334396a5ed187c1ca5bdaa37b4e74008"},"schema_version":"1.0","source":{"id":"2503.15745","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2503.15745","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"arxiv_version","alias_value":"2503.15745v2","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2503.15745","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"pith_short_12","alias_value":"SAL6YOV77M4I","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"pith_short_16","alias_value":"SAL6YOV77M4I5QTU","created_at":"2026-07-05T12:04:14Z"},{"alias_kind":"pith_short_8","alias_value":"SAL6YOV7","created_at":"2026-07-05T12:04:14Z"}],"graph_snapshots":[{"event_id":"sha256:a25514928fefdb62498b9ecb7073fba49818506d9fc5a36067c4b5472a51b218","target":"graph","created_at":"2026-07-05T12:04:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2503.15745/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The heterogeneous treatment effect plays a crucial role in precision medicine.There is evidence that real-world data, even subject to biases, can be employed as supplementary evidence for randomized clinical trials to improve the statistical efficiency of the heterogeneous treatment effect estimation. In this paper, for survival data with right censoring, we consider estimating the heterogeneous treatment effect, defined as the difference of the treatment-specific conditional restricted mean survival times given covariates, by synthesizing evidence from randomized clinical trials and the real-","authors_text":"Guangcai Mao, Shu Yang, Xiaofei Wang","cross_cats":["stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-03-19T23:26:32Z","title":"Statistical Inference for Heterogeneous Treatment Effect with Right-censored Data from Synthesizing Randomized Clinical Trials and Real-world Data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2503.15745","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:192fbf53dd1bfeb766d2a4d775b6be3ccd213f8566688b9ffd365b94252573f5","target":"record","created_at":"2026-07-05T12:04:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"29cce94e45c9f9ac87785586c90b519c473a88c10c1bb32327892f1f91bf721e","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-03-19T23:26:32Z","title_canon_sha256":"5d1630f9d67ac6cbeff76adb4fb2d562334396a5ed187c1ca5bdaa37b4e74008"},"schema_version":"1.0","source":{"id":"2503.15745","kind":"arxiv","version":2}},"canonical_sha256":"9017ec3abffb388ec274ecfd7c0f0cc0d16b9dd63cb45d0ad125bb16c4f5c019","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9017ec3abffb388ec274ecfd7c0f0cc0d16b9dd63cb45d0ad125bb16c4f5c019","first_computed_at":"2026-07-05T12:04:14.321226Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T12:04:14.321226Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3vAkhvswXE+vC+LAuf7yRjsgCaQgnaApR4QODrCHQtuNqb41X8RSUGovFR+xVHSyzXABnhaKDjAdjL/rnJLfDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T12:04:14.321729Z","signed_message":"canonical_sha256_bytes"},"source_id":"2503.15745","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:192fbf53dd1bfeb766d2a4d775b6be3ccd213f8566688b9ffd365b94252573f5","sha256:a25514928fefdb62498b9ecb7073fba49818506d9fc5a36067c4b5472a51b218"],"state_sha256":"b9728027f8a5f9b38bce7915d287599de1ba4591d7abedb8e27efa06d9a8ab3b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"h+oJVAYOo9tvB1IAtGOjqcuAyQsVTOM12mN3TZjYBCm4OWETH++bW/P5Z0YOBGPIdbbJlkqs6+YKI+jpzEFHBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-06T03:33:30.986583Z","bundle_sha256":"c78260644589c613dd4d15077ecbf46dbc8b196c397d61566d637247215b6d31"}}