{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:SCWD2CMGJH6II5CJWQG55PXLNG","short_pith_number":"pith:SCWD2CMG","canonical_record":{"source":{"id":"2502.19175","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"cs.CL","submitted_at":"2025-02-26T14:31:43Z","cross_cats_sorted":["cs.AI"],"title_canon_sha256":"6a50d58ee19efaaf14c3e35c33b6394201e3b0967a6ce4c93760ca67cca9d1b3","abstract_canon_sha256":"dc00e8bb7a2ff70fc18c4fb295ec5303d8c981dcb6bfdadd169565c0b12b9ca3"},"schema_version":"1.0"},"canonical_sha256":"90ac3d098649fc847449b40ddebeeb69b2b991f415d4d0ffa652a833bcd71fd5","source":{"kind":"arxiv","id":"2502.19175","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.19175","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"arxiv_version","alias_value":"2502.19175v2","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.19175","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"pith_short_12","alias_value":"SCWD2CMGJH6I","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"pith_short_16","alias_value":"SCWD2CMGJH6II5CJ","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"pith_short_8","alias_value":"SCWD2CMG","created_at":"2026-07-05T11:20:51Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:SCWD2CMGJH6II5CJWQG55PXLNG","target":"record","payload":{"canonical_record":{"source":{"id":"2502.19175","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"cs.CL","submitted_at":"2025-02-26T14:31:43Z","cross_cats_sorted":["cs.AI"],"title_canon_sha256":"6a50d58ee19efaaf14c3e35c33b6394201e3b0967a6ce4c93760ca67cca9d1b3","abstract_canon_sha256":"dc00e8bb7a2ff70fc18c4fb295ec5303d8c981dcb6bfdadd169565c0b12b9ca3"},"schema_version":"1.0"},"canonical_sha256":"90ac3d098649fc847449b40ddebeeb69b2b991f415d4d0ffa652a833bcd71fd5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:20:51.276145Z","signature_b64":"soLQBct8ajetsQ4hJnXogwG3U4zM3BRLEUPBmbC0z2yR8v1bvBvxydzCgWtcAsumvzRZTyY7FUjH86EfHYG7DQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"90ac3d098649fc847449b40ddebeeb69b2b991f415d4d0ffa652a833bcd71fd5","last_reissued_at":"2026-07-05T11:20:51.275702Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:20:51.275702Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2502.19175","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:20:51Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fxyawloAo0Lf663UUSDxy9yD4Dh7FPYlRMPNDGGp3B/h9oP/V+5IFEtWTtiX4pV0FrzLzrnbTNnmw2NJuh7mBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T08:31:56.568383Z"},"content_sha256":"ad53d18b771113f64c64a2cdd01aa143a8e793487710de2b3524bd0c0c49088b","schema_version":"1.0","event_id":"sha256:ad53d18b771113f64c64a2cdd01aa143a8e793487710de2b3524bd0c0c49088b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:SCWD2CMGJH6II5CJWQG55PXLNG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"MEDDxAgent: A Unified Modular Agent Framework for Explainable Automatic Differential Diagnosis","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["cs.AI"],"primary_cat":"cs.CL","authors_text":"Carolin Lawrence, Chia-Chien Hung, Daniel Rose, Israa Alqassem, Kiril Gashteovski, Marco Lepri","submitted_at":"2025-02-26T14:31:43Z","abstract_excerpt":"Differential Diagnosis (DDx) is a fundamental yet complex aspect of clinical decision-making, in which physicians iteratively refine a ranked list of possible diseases based on symptoms, antecedents, and medical knowledge. While recent advances in large language models (LLMs) have shown promise in supporting DDx, existing approaches face key limitations, including single-dataset evaluations, isolated optimization of components, unrealistic assumptions about complete patient profiles, and single-attempt diagnosis. We introduce a Modular Explainable DDx Agent (MEDDxAgent) framework designed for "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.19175","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2502.19175/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:20:51Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HFV7vKCYFLpmjXVVAPFK8bLeP5jlL3sSl0IsK5j73+hlILbmB7n1rfpoezoRNraAZd6ubTwVQGIPmgft1vAbBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T08:31:56.568936Z"},"content_sha256":"3eeb2683280bd58945394f55b023400f0ad2db706f9f7d1ee8041149e776924b","schema_version":"1.0","event_id":"sha256:3eeb2683280bd58945394f55b023400f0ad2db706f9f7d1ee8041149e776924b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/SCWD2CMGJH6II5CJWQG55PXLNG/bundle.json","state_url":"https://pith.science/pith/SCWD2CMGJH6II5CJWQG55PXLNG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/SCWD2CMGJH6II5CJWQG55PXLNG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-06T08:31:56Z","links":{"resolver":"https://pith.science/pith/SCWD2CMGJH6II5CJWQG55PXLNG","bundle":"https://pith.science/pith/SCWD2CMGJH6II5CJWQG55PXLNG/bundle.json","state":"https://pith.science/pith/SCWD2CMGJH6II5CJWQG55PXLNG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/SCWD2CMGJH6II5CJWQG55PXLNG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:SCWD2CMGJH6II5CJWQG55PXLNG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"dc00e8bb7a2ff70fc18c4fb295ec5303d8c981dcb6bfdadd169565c0b12b9ca3","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"cs.CL","submitted_at":"2025-02-26T14:31:43Z","title_canon_sha256":"6a50d58ee19efaaf14c3e35c33b6394201e3b0967a6ce4c93760ca67cca9d1b3"},"schema_version":"1.0","source":{"id":"2502.19175","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.19175","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"arxiv_version","alias_value":"2502.19175v2","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.19175","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"pith_short_12","alias_value":"SCWD2CMGJH6I","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"pith_short_16","alias_value":"SCWD2CMGJH6II5CJ","created_at":"2026-07-05T11:20:51Z"},{"alias_kind":"pith_short_8","alias_value":"SCWD2CMG","created_at":"2026-07-05T11:20:51Z"}],"graph_snapshots":[{"event_id":"sha256:3eeb2683280bd58945394f55b023400f0ad2db706f9f7d1ee8041149e776924b","target":"graph","created_at":"2026-07-05T11:20:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2502.19175/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Differential Diagnosis (DDx) is a fundamental yet complex aspect of clinical decision-making, in which physicians iteratively refine a ranked list of possible diseases based on symptoms, antecedents, and medical knowledge. While recent advances in large language models (LLMs) have shown promise in supporting DDx, existing approaches face key limitations, including single-dataset evaluations, isolated optimization of components, unrealistic assumptions about complete patient profiles, and single-attempt diagnosis. We introduce a Modular Explainable DDx Agent (MEDDxAgent) framework designed for ","authors_text":"Carolin Lawrence, Chia-Chien Hung, Daniel Rose, Israa Alqassem, Kiril Gashteovski, Marco Lepri","cross_cats":["cs.AI"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"cs.CL","submitted_at":"2025-02-26T14:31:43Z","title":"MEDDxAgent: A Unified Modular Agent Framework for Explainable Automatic Differential Diagnosis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.19175","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ad53d18b771113f64c64a2cdd01aa143a8e793487710de2b3524bd0c0c49088b","target":"record","created_at":"2026-07-05T11:20:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"dc00e8bb7a2ff70fc18c4fb295ec5303d8c981dcb6bfdadd169565c0b12b9ca3","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"cs.CL","submitted_at":"2025-02-26T14:31:43Z","title_canon_sha256":"6a50d58ee19efaaf14c3e35c33b6394201e3b0967a6ce4c93760ca67cca9d1b3"},"schema_version":"1.0","source":{"id":"2502.19175","kind":"arxiv","version":2}},"canonical_sha256":"90ac3d098649fc847449b40ddebeeb69b2b991f415d4d0ffa652a833bcd71fd5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"90ac3d098649fc847449b40ddebeeb69b2b991f415d4d0ffa652a833bcd71fd5","first_computed_at":"2026-07-05T11:20:51.275702Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:20:51.275702Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"soLQBct8ajetsQ4hJnXogwG3U4zM3BRLEUPBmbC0z2yR8v1bvBvxydzCgWtcAsumvzRZTyY7FUjH86EfHYG7DQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:20:51.276145Z","signed_message":"canonical_sha256_bytes"},"source_id":"2502.19175","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ad53d18b771113f64c64a2cdd01aa143a8e793487710de2b3524bd0c0c49088b","sha256:3eeb2683280bd58945394f55b023400f0ad2db706f9f7d1ee8041149e776924b"],"state_sha256":"9247a9a35b4e09249f420dde2533be77180f8927726ebafdab59565a2a2fb3fe"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cbQmcG+npTuhekH7O6HYEI1hpzQqITigd1j9pUWSpBN4FLQVJdTD1fOjGCUtL7u4UypAx7n430dXSrYERoCSDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-06T08:31:56.574435Z","bundle_sha256":"cedafb5df1b751f80cf5abdef54e455ab4d23dc372f205e983a53e1b4b0813aa"}}