{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:SD4TTER5RMSODRAS3BGYV5FSFH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"dab37c06c2f73c9fc1cc5eca32d648c3fd0c81da9b5a8e2699e4323f0b886476","cross_cats_sorted":["cond-mat.dis-nn","cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-10-14T14:26:35Z","title_canon_sha256":"333ae0f0b90a9d8aec90460858b4407586e0f3878e108bfbe9c94c39830114c2"},"schema_version":"1.0","source":{"id":"1310.3693","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1310.3693","created_at":"2026-05-18T03:10:35Z"},{"alias_kind":"arxiv_version","alias_value":"1310.3693v1","created_at":"2026-05-18T03:10:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1310.3693","created_at":"2026-05-18T03:10:35Z"},{"alias_kind":"pith_short_12","alias_value":"SD4TTER5RMSO","created_at":"2026-05-18T12:27:59Z"},{"alias_kind":"pith_short_16","alias_value":"SD4TTER5RMSODRAS","created_at":"2026-05-18T12:27:59Z"},{"alias_kind":"pith_short_8","alias_value":"SD4TTER5","created_at":"2026-05-18T12:27:59Z"}],"graph_snapshots":[{"event_id":"sha256:54a3b75f18bef540befbc3f44f6a1be6ae2c8b62eaff333f95cbab43ce246bab","target":"graph","created_at":"2026-05-18T03:10:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Thermodynamics constrains the flow of matter in a reaction network to occur through routes along which the Gibbs energy decreases, implying that viable steady-state flux patterns should be void of closed reaction cycles. Identifying and removing cycles in large reaction networks can unfortunately be a highly challenging task from a computational viewpoint. We propose here a method that accomplishes it by combining a relaxation algorithm and a Monte Carlo procedure to detect loops, with ad hoc rules (discussed in detail) to eliminate them. As test cases, we tackle (a) the problem of identifying","authors_text":"Andrea De Martino, Daniele De Martino, Enzo Marinari, Fabrizio Capuani, Matteo Mori","cross_cats":["cond-mat.dis-nn","cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-10-14T14:26:35Z","title":"Counting and correcting thermodynamically infeasible flux cycles in genome-scale metabolic networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1310.3693","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:275281627bf215bd66ff5330bf4daf204d60f998a4f0204cc7e403c164865d75","target":"record","created_at":"2026-05-18T03:10:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"dab37c06c2f73c9fc1cc5eca32d648c3fd0c81da9b5a8e2699e4323f0b886476","cross_cats_sorted":["cond-mat.dis-nn","cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2013-10-14T14:26:35Z","title_canon_sha256":"333ae0f0b90a9d8aec90460858b4407586e0f3878e108bfbe9c94c39830114c2"},"schema_version":"1.0","source":{"id":"1310.3693","kind":"arxiv","version":1}},"canonical_sha256":"90f939923d8b24e1c412d84d8af4b229fb4ca601945ba4dbebc8d8f8c76e7453","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"90f939923d8b24e1c412d84d8af4b229fb4ca601945ba4dbebc8d8f8c76e7453","first_computed_at":"2026-05-18T03:10:35.101443Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:10:35.101443Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ylhEnL8kHm1eVzJeZIzD20MdXEvPGIUzxBGv92lUjv/vQZpdUlgyXI1HRCnrldWTEGkbc+gVNDzS5RUPPKAyDg==","signature_status":"signed_v1","signed_at":"2026-05-18T03:10:35.102002Z","signed_message":"canonical_sha256_bytes"},"source_id":"1310.3693","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:275281627bf215bd66ff5330bf4daf204d60f998a4f0204cc7e403c164865d75","sha256:54a3b75f18bef540befbc3f44f6a1be6ae2c8b62eaff333f95cbab43ce246bab"],"state_sha256":"669a54a9a51d041335285e8c40a6f35eb725f6808e1359091fecfcbad3db69b6"}