{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:SDQI5PWZHYHXLJHULIMKKFZUGF","short_pith_number":"pith:SDQI5PWZ","canonical_record":{"source":{"id":"1906.08481","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-06-20T07:49:22Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"e95c7b3d60536df89e31e32dc7cc16c6db39702958a31fa18b7350dc5777de4a","abstract_canon_sha256":"52b3ef14240b5e382402588cdb456c3975b1d46488d1718609d2d0e9d3f0b73d"},"schema_version":"1.0"},"canonical_sha256":"90e08ebed93e0f75a4f45a18a51734316950557fdb2519e8518333ace5aca576","source":{"kind":"arxiv","id":"1906.08481","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1906.08481","created_at":"2026-05-17T23:42:52Z"},{"alias_kind":"arxiv_version","alias_value":"1906.08481v1","created_at":"2026-05-17T23:42:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1906.08481","created_at":"2026-05-17T23:42:52Z"},{"alias_kind":"pith_short_12","alias_value":"SDQI5PWZHYHX","created_at":"2026-05-18T12:33:27Z"},{"alias_kind":"pith_short_16","alias_value":"SDQI5PWZHYHXLJHU","created_at":"2026-05-18T12:33:27Z"},{"alias_kind":"pith_short_8","alias_value":"SDQI5PWZ","created_at":"2026-05-18T12:33:27Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:SDQI5PWZHYHXLJHULIMKKFZUGF","target":"record","payload":{"canonical_record":{"source":{"id":"1906.08481","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-06-20T07:49:22Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"e95c7b3d60536df89e31e32dc7cc16c6db39702958a31fa18b7350dc5777de4a","abstract_canon_sha256":"52b3ef14240b5e382402588cdb456c3975b1d46488d1718609d2d0e9d3f0b73d"},"schema_version":"1.0"},"canonical_sha256":"90e08ebed93e0f75a4f45a18a51734316950557fdb2519e8518333ace5aca576","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:42:52.358975Z","signature_b64":"b2gbA/cteC+LvsvP/iNqFqAKONmINSB1R7vzGoNQCK3xlw98BSCbRggKpFjfwK/VhU+iErMfgLC2zzI5c1nGDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"90e08ebed93e0f75a4f45a18a51734316950557fdb2519e8518333ace5aca576","last_reissued_at":"2026-05-17T23:42:52.358391Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:42:52.358391Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1906.08481","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:42:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4CMgIOuyhkKP7D5CAUJX+UKvlcQf8+o4vvjKAMq0nn3yrcV2/E8JGspjnK4VSr49iCjarrFNIZDc9kBEPyQaBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T01:00:29.059851Z"},"content_sha256":"baf45e0c1469886e9e79e8f933805c004b139566e73a537081d2406e097dedc6","schema_version":"1.0","event_id":"sha256:baf45e0c1469886e9e79e8f933805c004b139566e73a537081d2406e097dedc6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:SDQI5PWZHYHXLJHULIMKKFZUGF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Detecting long-range attraction between migrating cells based on p-value distributions","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"q-bio.QM","authors_text":"Claus Metzner","submitted_at":"2019-06-20T07:49:22Z","abstract_excerpt":"Immune cells have evolved to recognize and eliminate pathogens, and the efficiency of this process can be measured in a Petri dish. Yet, even if the cells are time-lapse recorded and tracked with high resolution, it is difficult to judge whether the immune cells find their targets by mere chance, or if they approach them in a goal-directed way, perhaps using remote sensing mechanisms such as chemotaxis. To answer this question, we assign to each step of an immune cell a 'p-value', the probability that a move, at least as target-directed as observed, can be explained with target-independent mig"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1906.08481","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:42:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"A+GbsxlyOPZ687UognyAjFiNumdTDf01RZs9r0MgRgFn7Jm0vxnTDYjn8nxGOokjnXZ8OhoZyWo9MNgVyPcIAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T01:00:29.060219Z"},"content_sha256":"a3c1f770160ea781f21b0bb9c67d6fdf6594ad66fbdd16ab4ea697ae56d2a175","schema_version":"1.0","event_id":"sha256:a3c1f770160ea781f21b0bb9c67d6fdf6594ad66fbdd16ab4ea697ae56d2a175"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/SDQI5PWZHYHXLJHULIMKKFZUGF/bundle.json","state_url":"https://pith.science/pith/SDQI5PWZHYHXLJHULIMKKFZUGF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/SDQI5PWZHYHXLJHULIMKKFZUGF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T01:00:29Z","links":{"resolver":"https://pith.science/pith/SDQI5PWZHYHXLJHULIMKKFZUGF","bundle":"https://pith.science/pith/SDQI5PWZHYHXLJHULIMKKFZUGF/bundle.json","state":"https://pith.science/pith/SDQI5PWZHYHXLJHULIMKKFZUGF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/SDQI5PWZHYHXLJHULIMKKFZUGF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:SDQI5PWZHYHXLJHULIMKKFZUGF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"52b3ef14240b5e382402588cdb456c3975b1d46488d1718609d2d0e9d3f0b73d","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-06-20T07:49:22Z","title_canon_sha256":"e95c7b3d60536df89e31e32dc7cc16c6db39702958a31fa18b7350dc5777de4a"},"schema_version":"1.0","source":{"id":"1906.08481","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1906.08481","created_at":"2026-05-17T23:42:52Z"},{"alias_kind":"arxiv_version","alias_value":"1906.08481v1","created_at":"2026-05-17T23:42:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1906.08481","created_at":"2026-05-17T23:42:52Z"},{"alias_kind":"pith_short_12","alias_value":"SDQI5PWZHYHX","created_at":"2026-05-18T12:33:27Z"},{"alias_kind":"pith_short_16","alias_value":"SDQI5PWZHYHXLJHU","created_at":"2026-05-18T12:33:27Z"},{"alias_kind":"pith_short_8","alias_value":"SDQI5PWZ","created_at":"2026-05-18T12:33:27Z"}],"graph_snapshots":[{"event_id":"sha256:a3c1f770160ea781f21b0bb9c67d6fdf6594ad66fbdd16ab4ea697ae56d2a175","target":"graph","created_at":"2026-05-17T23:42:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Immune cells have evolved to recognize and eliminate pathogens, and the efficiency of this process can be measured in a Petri dish. Yet, even if the cells are time-lapse recorded and tracked with high resolution, it is difficult to judge whether the immune cells find their targets by mere chance, or if they approach them in a goal-directed way, perhaps using remote sensing mechanisms such as chemotaxis. To answer this question, we assign to each step of an immune cell a 'p-value', the probability that a move, at least as target-directed as observed, can be explained with target-independent mig","authors_text":"Claus Metzner","cross_cats":["q-bio.CB"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-06-20T07:49:22Z","title":"Detecting long-range attraction between migrating cells based on p-value distributions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1906.08481","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:baf45e0c1469886e9e79e8f933805c004b139566e73a537081d2406e097dedc6","target":"record","created_at":"2026-05-17T23:42:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"52b3ef14240b5e382402588cdb456c3975b1d46488d1718609d2d0e9d3f0b73d","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-06-20T07:49:22Z","title_canon_sha256":"e95c7b3d60536df89e31e32dc7cc16c6db39702958a31fa18b7350dc5777de4a"},"schema_version":"1.0","source":{"id":"1906.08481","kind":"arxiv","version":1}},"canonical_sha256":"90e08ebed93e0f75a4f45a18a51734316950557fdb2519e8518333ace5aca576","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"90e08ebed93e0f75a4f45a18a51734316950557fdb2519e8518333ace5aca576","first_computed_at":"2026-05-17T23:42:52.358391Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:42:52.358391Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"b2gbA/cteC+LvsvP/iNqFqAKONmINSB1R7vzGoNQCK3xlw98BSCbRggKpFjfwK/VhU+iErMfgLC2zzI5c1nGDw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:42:52.358975Z","signed_message":"canonical_sha256_bytes"},"source_id":"1906.08481","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:baf45e0c1469886e9e79e8f933805c004b139566e73a537081d2406e097dedc6","sha256:a3c1f770160ea781f21b0bb9c67d6fdf6594ad66fbdd16ab4ea697ae56d2a175"],"state_sha256":"c0c47ab4a09d6aec6bed1e02aeee94656f65d078961cc208a8af2460a4e2671e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"eTYDCkIgQpNn6qfbYjQI6nATyAZuZ7ZNo55vh9P//kxTaGrWfQP63PIxB6NeLWmo+tUUOZFL9/FBlE9fkFHIDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T01:00:29.063410Z","bundle_sha256":"ad54f469bdb45b14f114b8d42aaf7738fba3c6c42ea1b0d2491d3ee9bb999e27"}}