{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2005:SNN67JGRX2TPRM37LO7RIPOPLB","short_pith_number":"pith:SNN67JGR","canonical_record":{"source":{"id":"q-bio/0502023","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2005-02-21T02:42:32Z","cross_cats_sorted":["cs.NE"],"title_canon_sha256":"0b1f03be1f5eced60c430de97e1fd406cf3f48e6a2f2be1bdd4b51577424517a","abstract_canon_sha256":"72af6f45446c5a7cec3ddc377f4e709acb8876fbbbe58513df1a2a352d6440b2"},"schema_version":"1.0"},"canonical_sha256":"935befa4d1bea6f8b37f5bbf143dcf58625bace38be5fd948789af174c264afb","source":{"kind":"arxiv","id":"q-bio/0502023","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"q-bio/0502023","created_at":"2026-05-18T00:36:36Z"},{"alias_kind":"arxiv_version","alias_value":"q-bio/0502023v4","created_at":"2026-05-18T00:36:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.q-bio/0502023","created_at":"2026-05-18T00:36:36Z"},{"alias_kind":"pith_short_12","alias_value":"SNN67JGRX2TP","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_16","alias_value":"SNN67JGRX2TPRM37","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_8","alias_value":"SNN67JGR","created_at":"2026-05-18T12:25:53Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2005:SNN67JGRX2TPRM37LO7RIPOPLB","target":"record","payload":{"canonical_record":{"source":{"id":"q-bio/0502023","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2005-02-21T02:42:32Z","cross_cats_sorted":["cs.NE"],"title_canon_sha256":"0b1f03be1f5eced60c430de97e1fd406cf3f48e6a2f2be1bdd4b51577424517a","abstract_canon_sha256":"72af6f45446c5a7cec3ddc377f4e709acb8876fbbbe58513df1a2a352d6440b2"},"schema_version":"1.0"},"canonical_sha256":"935befa4d1bea6f8b37f5bbf143dcf58625bace38be5fd948789af174c264afb","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:36:36.043500Z","signature_b64":"u6Z1ai2m9CndtcNE4efM1F0KM0XujeDG0Ba4Se5ZKEIa8iBGUeGdeiRop8L5L1XyN6TY+BYkmE5YtyixjkAgDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"935befa4d1bea6f8b37f5bbf143dcf58625bace38be5fd948789af174c264afb","last_reissued_at":"2026-05-18T00:36:36.042926Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:36:36.042926Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"q-bio/0502023","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:36:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"E9lEYHWuwd1U0Kh3OlIO6m0fLRFtUiW896alSPbGNTzfy3Rz0iv6xzXulm35eL7d2cMXuuHRDymHoOKfzZoGAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T07:11:25.740967Z"},"content_sha256":"437b92f8ad09a3a58d4e0c0d7fc8e63a5b66522344cc44c54592465ca758c3f5","schema_version":"1.0","event_id":"sha256:437b92f8ad09a3a58d4e0c0d7fc8e63a5b66522344cc44c54592465ca758c3f5"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2005:SNN67JGRX2TPRM37LO7RIPOPLB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Learning intrinsic excitability in medium spiny neurons","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.NE"],"primary_cat":"q-bio.NC","authors_text":"Gabriele Scheler","submitted_at":"2005-02-21T02:42:32Z","abstract_excerpt":"We present an unsupervised, local activation-dependent learning rule for intrinsic plasticity (IP) which affects the composition of ion channel conductances for single neurons in a use-dependent way. We use a single-compartment conductance-based model for medium spiny striatal neurons in order to show the effects of parametrization of individual ion channels on the neuronal activation function. We show that parameter changes within the physiological ranges are sufficient to create an ensemble of neurons with significantly different activation functions. We emphasize that the effects of intrins"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0502023","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:36:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9FU25WZQldafujVxNQzvDeOIPXqF3/dugkDJPSIV6tcHtMom13rZX3NAOKVCGcfNXhCsRbl6HHVoHs23WilRAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T07:11:25.741793Z"},"content_sha256":"2b2dc9d9d02de51a52cf53e93105c390551b922e99ae91b9430706e52ad253b6","schema_version":"1.0","event_id":"sha256:2b2dc9d9d02de51a52cf53e93105c390551b922e99ae91b9430706e52ad253b6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/SNN67JGRX2TPRM37LO7RIPOPLB/bundle.json","state_url":"https://pith.science/pith/SNN67JGRX2TPRM37LO7RIPOPLB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/SNN67JGRX2TPRM37LO7RIPOPLB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-11T07:11:25Z","links":{"resolver":"https://pith.science/pith/SNN67JGRX2TPRM37LO7RIPOPLB","bundle":"https://pith.science/pith/SNN67JGRX2TPRM37LO7RIPOPLB/bundle.json","state":"https://pith.science/pith/SNN67JGRX2TPRM37LO7RIPOPLB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/SNN67JGRX2TPRM37LO7RIPOPLB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2005:SNN67JGRX2TPRM37LO7RIPOPLB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"72af6f45446c5a7cec3ddc377f4e709acb8876fbbbe58513df1a2a352d6440b2","cross_cats_sorted":["cs.NE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2005-02-21T02:42:32Z","title_canon_sha256":"0b1f03be1f5eced60c430de97e1fd406cf3f48e6a2f2be1bdd4b51577424517a"},"schema_version":"1.0","source":{"id":"q-bio/0502023","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"q-bio/0502023","created_at":"2026-05-18T00:36:36Z"},{"alias_kind":"arxiv_version","alias_value":"q-bio/0502023v4","created_at":"2026-05-18T00:36:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.q-bio/0502023","created_at":"2026-05-18T00:36:36Z"},{"alias_kind":"pith_short_12","alias_value":"SNN67JGRX2TP","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_16","alias_value":"SNN67JGRX2TPRM37","created_at":"2026-05-18T12:25:53Z"},{"alias_kind":"pith_short_8","alias_value":"SNN67JGR","created_at":"2026-05-18T12:25:53Z"}],"graph_snapshots":[{"event_id":"sha256:2b2dc9d9d02de51a52cf53e93105c390551b922e99ae91b9430706e52ad253b6","target":"graph","created_at":"2026-05-18T00:36:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We present an unsupervised, local activation-dependent learning rule for intrinsic plasticity (IP) which affects the composition of ion channel conductances for single neurons in a use-dependent way. We use a single-compartment conductance-based model for medium spiny striatal neurons in order to show the effects of parametrization of individual ion channels on the neuronal activation function. We show that parameter changes within the physiological ranges are sufficient to create an ensemble of neurons with significantly different activation functions. We emphasize that the effects of intrins","authors_text":"Gabriele Scheler","cross_cats":["cs.NE"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2005-02-21T02:42:32Z","title":"Learning intrinsic excitability in medium spiny neurons"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0502023","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:437b92f8ad09a3a58d4e0c0d7fc8e63a5b66522344cc44c54592465ca758c3f5","target":"record","created_at":"2026-05-18T00:36:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"72af6f45446c5a7cec3ddc377f4e709acb8876fbbbe58513df1a2a352d6440b2","cross_cats_sorted":["cs.NE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2005-02-21T02:42:32Z","title_canon_sha256":"0b1f03be1f5eced60c430de97e1fd406cf3f48e6a2f2be1bdd4b51577424517a"},"schema_version":"1.0","source":{"id":"q-bio/0502023","kind":"arxiv","version":4}},"canonical_sha256":"935befa4d1bea6f8b37f5bbf143dcf58625bace38be5fd948789af174c264afb","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"935befa4d1bea6f8b37f5bbf143dcf58625bace38be5fd948789af174c264afb","first_computed_at":"2026-05-18T00:36:36.042926Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:36:36.042926Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"u6Z1ai2m9CndtcNE4efM1F0KM0XujeDG0Ba4Se5ZKEIa8iBGUeGdeiRop8L5L1XyN6TY+BYkmE5YtyixjkAgDg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:36:36.043500Z","signed_message":"canonical_sha256_bytes"},"source_id":"q-bio/0502023","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:437b92f8ad09a3a58d4e0c0d7fc8e63a5b66522344cc44c54592465ca758c3f5","sha256:2b2dc9d9d02de51a52cf53e93105c390551b922e99ae91b9430706e52ad253b6"],"state_sha256":"13c8ddb1eead622ee6914bc30ce045f9e3ff42d7407e3170c30999e05524fb0b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"FUsZjeDbNq0lKkEOHprA0Tn/n70FmilnzmiZ6hpAj141iuA6GpMc7oxMSOiL15Y9mzNu0tXMUL3j1Y9gAxveAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-11T07:11:25.746806Z","bundle_sha256":"2307ae68f292598d0241d719156f5ee4c036c2826008e31cbea0e00f47a7722f"}}