{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2026:SSZNLLKICTGRXNYTLCI6IMB7OL","short_pith_number":"pith:SSZNLLKI","schema_version":"1.0","canonical_sha256":"94b2d5ad4814cd1bb7135891e4303f72c006416862d88fbdbddab49a26bfb668","source":{"kind":"arxiv","id":"2606.17327","version":1},"attestation_state":"computed","paper":{"title":"Energy-efficient codon optimization on thermodynamic hardware","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cs.AR","cs.ET","cs.NE"],"primary_cat":"q-bio.BM","authors_text":"Andraz Jelincic, Ross C. Walker","submitted_at":"2026-06-15T22:20:44Z","abstract_excerpt":"The growing energy demand for computation is becoming increasingly unsustainable. Thermodynamic computing, which harnesses physical thermal fluctuations as a computational resource rather than suppressing them, offers orders-of-magnitude energy savings for probabilistic and combinatorial tasks. Pharmaceutical R&D, heavily reliant on computational optimization and sampling, is a natural application domain. Here we present what is, to our knowledge, the first concrete pharmaceutical application mapped to thermodynamic hardware with energy estimates grounded in prototype measurements. We reduce m"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2606.17327","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-06-15T22:20:44Z","cross_cats_sorted":["cs.AR","cs.ET","cs.NE"],"title_canon_sha256":"f8d2af465743458a20d721709c7bfdb758b8d402d0829f42f171f4cf33fce745","abstract_canon_sha256":"d5178ee7f98b4be2df322735b9c6c1be95890852aac777f8a56862acfae93160"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-19T16:10:09.343221Z","signature_b64":"NZTwwMLwESgRgXvrqqd6I4W+O+Q+IOf0zgk2o01vj6ZF3tkslqa+X4Ou38cBQB9+4qUrcW5ikl036AsmSGOkCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"94b2d5ad4814cd1bb7135891e4303f72c006416862d88fbdbddab49a26bfb668","last_reissued_at":"2026-06-19T16:10:09.342885Z","signature_status":"signed_v1","first_computed_at":"2026-06-19T16:10:09.342885Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Energy-efficient codon optimization on thermodynamic hardware","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cs.AR","cs.ET","cs.NE"],"primary_cat":"q-bio.BM","authors_text":"Andraz Jelincic, Ross C. Walker","submitted_at":"2026-06-15T22:20:44Z","abstract_excerpt":"The growing energy demand for computation is becoming increasingly unsustainable. Thermodynamic computing, which harnesses physical thermal fluctuations as a computational resource rather than suppressing them, offers orders-of-magnitude energy savings for probabilistic and combinatorial tasks. Pharmaceutical R&D, heavily reliant on computational optimization and sampling, is a natural application domain. Here we present what is, to our knowledge, the first concrete pharmaceutical application mapped to thermodynamic hardware with energy estimates grounded in prototype measurements. We reduce m"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.17327","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.17327/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2606.17327","created_at":"2026-06-19T16:10:09.342941+00:00"},{"alias_kind":"arxiv_version","alias_value":"2606.17327v1","created_at":"2026-06-19T16:10:09.342941+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.17327","created_at":"2026-06-19T16:10:09.342941+00:00"},{"alias_kind":"pith_short_12","alias_value":"SSZNLLKICTGR","created_at":"2026-06-19T16:10:09.342941+00:00"},{"alias_kind":"pith_short_16","alias_value":"SSZNLLKICTGRXNYT","created_at":"2026-06-19T16:10:09.342941+00:00"},{"alias_kind":"pith_short_8","alias_value":"SSZNLLKI","created_at":"2026-06-19T16:10:09.342941+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL","json":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL.json","graph_json":"https://pith.science/api/pith-number/SSZNLLKICTGRXNYTLCI6IMB7OL/graph.json","events_json":"https://pith.science/api/pith-number/SSZNLLKICTGRXNYTLCI6IMB7OL/events.json","paper":"https://pith.science/paper/SSZNLLKI"},"agent_actions":{"view_html":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL","download_json":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL.json","view_paper":"https://pith.science/paper/SSZNLLKI","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2606.17327&json=true","fetch_graph":"https://pith.science/api/pith-number/SSZNLLKICTGRXNYTLCI6IMB7OL/graph.json","fetch_events":"https://pith.science/api/pith-number/SSZNLLKICTGRXNYTLCI6IMB7OL/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL/action/timestamp_anchor","attest_storage":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL/action/storage_attestation","attest_author":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL/action/author_attestation","sign_citation":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL/action/citation_signature","submit_replication":"https://pith.science/pith/SSZNLLKICTGRXNYTLCI6IMB7OL/action/replication_record"}},"created_at":"2026-06-19T16:10:09.342941+00:00","updated_at":"2026-06-19T16:10:09.342941+00:00"}