{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:SZ3KCW2ISOFHQX5ZIW2XCBV6QQ","short_pith_number":"pith:SZ3KCW2I","canonical_record":{"source":{"id":"1601.04458","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-01-18T10:38:52Z","cross_cats_sorted":["cs.DS","cs.MS"],"title_canon_sha256":"c6326a5039481576baf541708ca691a5fc23e1a442736f53189f903d95ec0df0","abstract_canon_sha256":"68afac330a05caae79f6f9e2b90e34225c1128726acead5e464f0ed72530b8fc"},"schema_version":"1.0"},"canonical_sha256":"9676a15b48938a785fb945b57106be843455f721d8f5e3c3e8e74acf6bdd8488","source":{"kind":"arxiv","id":"1601.04458","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1601.04458","created_at":"2026-05-18T01:22:44Z"},{"alias_kind":"arxiv_version","alias_value":"1601.04458v1","created_at":"2026-05-18T01:22:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1601.04458","created_at":"2026-05-18T01:22:44Z"},{"alias_kind":"pith_short_12","alias_value":"SZ3KCW2ISOFH","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_16","alias_value":"SZ3KCW2ISOFHQX5Z","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_8","alias_value":"SZ3KCW2I","created_at":"2026-05-18T12:30:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:SZ3KCW2ISOFHQX5ZIW2XCBV6QQ","target":"record","payload":{"canonical_record":{"source":{"id":"1601.04458","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-01-18T10:38:52Z","cross_cats_sorted":["cs.DS","cs.MS"],"title_canon_sha256":"c6326a5039481576baf541708ca691a5fc23e1a442736f53189f903d95ec0df0","abstract_canon_sha256":"68afac330a05caae79f6f9e2b90e34225c1128726acead5e464f0ed72530b8fc"},"schema_version":"1.0"},"canonical_sha256":"9676a15b48938a785fb945b57106be843455f721d8f5e3c3e8e74acf6bdd8488","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:22:44.987142Z","signature_b64":"9Kt5L49zWuXquZdNWcgVs+NZjvVOoA4n2Dn13Q9t3b6F3qyK9oRtOuP3WCeDEy1Y8N8oIdMNFAf+lXLIJ8GTDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9676a15b48938a785fb945b57106be843455f721d8f5e3c3e8e74acf6bdd8488","last_reissued_at":"2026-05-18T01:22:44.986506Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:22:44.986506Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1601.04458","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:22:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lPZpYotD9M9FZDAKPHGy2xjsTzaJRDDG8om/RBuVXoxAAVUzV0q9AjacNbGGFYtvwgYMVIFWJIDZyTIAb1MtDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-23T14:11:09.362179Z"},"content_sha256":"79428f47e0135e0c2c42ebfa1dc3cb475e0f511b69351f4a4a425db227ad8baa","schema_version":"1.0","event_id":"sha256:79428f47e0135e0c2c42ebfa1dc3cb475e0f511b69351f4a4a425db227ad8baa"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:SZ3KCW2ISOFHQX5ZIW2XCBV6QQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Reducing local minima in fitness landscapes of parameter estimation by using piecewise evaluation and state estimation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.DS","cs.MS"],"primary_cat":"q-bio.QM","authors_text":"Christoph Zimmer, Frank T. Bergmann, Sven Sahle","submitted_at":"2016-01-18T10:38:52Z","abstract_excerpt":"Ordinary differential equations (ODE) are widely used for modeling in Systems Biology. As most commonly only some of the kinetic parameters are measurable or precisely known, parameter estimation techniques are applied to parametrize the model to experimental data. A main challenge for the parameter estimation is the complexity of the parameter space, especially its high dimensionality and local minima.\n  Parameter estimation techniques consist of an objective function, measuring how well a certain parameter set describes the experimental data, and an optimization algorithm that optimizes this"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1601.04458","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:22:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rFdnsoDPMyblFNMNQjtVLfrGDv720D0/Mymr8PQJx2Iomr6Fu9+JNWcKj6f7jL3sd1kNgAKqu1JcR2GYdFxVDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-23T14:11:09.362890Z"},"content_sha256":"0c41df31c795bc2d0b76581b5eb486b4f8ce3a78e4d4ea16a8b64f8ded474431","schema_version":"1.0","event_id":"sha256:0c41df31c795bc2d0b76581b5eb486b4f8ce3a78e4d4ea16a8b64f8ded474431"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/SZ3KCW2ISOFHQX5ZIW2XCBV6QQ/bundle.json","state_url":"https://pith.science/pith/SZ3KCW2ISOFHQX5ZIW2XCBV6QQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/SZ3KCW2ISOFHQX5ZIW2XCBV6QQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-23T14:11:09Z","links":{"resolver":"https://pith.science/pith/SZ3KCW2ISOFHQX5ZIW2XCBV6QQ","bundle":"https://pith.science/pith/SZ3KCW2ISOFHQX5ZIW2XCBV6QQ/bundle.json","state":"https://pith.science/pith/SZ3KCW2ISOFHQX5ZIW2XCBV6QQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/SZ3KCW2ISOFHQX5ZIW2XCBV6QQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:SZ3KCW2ISOFHQX5ZIW2XCBV6QQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"68afac330a05caae79f6f9e2b90e34225c1128726acead5e464f0ed72530b8fc","cross_cats_sorted":["cs.DS","cs.MS"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-01-18T10:38:52Z","title_canon_sha256":"c6326a5039481576baf541708ca691a5fc23e1a442736f53189f903d95ec0df0"},"schema_version":"1.0","source":{"id":"1601.04458","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1601.04458","created_at":"2026-05-18T01:22:44Z"},{"alias_kind":"arxiv_version","alias_value":"1601.04458v1","created_at":"2026-05-18T01:22:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1601.04458","created_at":"2026-05-18T01:22:44Z"},{"alias_kind":"pith_short_12","alias_value":"SZ3KCW2ISOFH","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_16","alias_value":"SZ3KCW2ISOFHQX5Z","created_at":"2026-05-18T12:30:44Z"},{"alias_kind":"pith_short_8","alias_value":"SZ3KCW2I","created_at":"2026-05-18T12:30:44Z"}],"graph_snapshots":[{"event_id":"sha256:0c41df31c795bc2d0b76581b5eb486b4f8ce3a78e4d4ea16a8b64f8ded474431","target":"graph","created_at":"2026-05-18T01:22:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Ordinary differential equations (ODE) are widely used for modeling in Systems Biology. As most commonly only some of the kinetic parameters are measurable or precisely known, parameter estimation techniques are applied to parametrize the model to experimental data. A main challenge for the parameter estimation is the complexity of the parameter space, especially its high dimensionality and local minima.\n  Parameter estimation techniques consist of an objective function, measuring how well a certain parameter set describes the experimental data, and an optimization algorithm that optimizes this","authors_text":"Christoph Zimmer, Frank T. Bergmann, Sven Sahle","cross_cats":["cs.DS","cs.MS"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-01-18T10:38:52Z","title":"Reducing local minima in fitness landscapes of parameter estimation by using piecewise evaluation and state estimation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1601.04458","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:79428f47e0135e0c2c42ebfa1dc3cb475e0f511b69351f4a4a425db227ad8baa","target":"record","created_at":"2026-05-18T01:22:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"68afac330a05caae79f6f9e2b90e34225c1128726acead5e464f0ed72530b8fc","cross_cats_sorted":["cs.DS","cs.MS"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-01-18T10:38:52Z","title_canon_sha256":"c6326a5039481576baf541708ca691a5fc23e1a442736f53189f903d95ec0df0"},"schema_version":"1.0","source":{"id":"1601.04458","kind":"arxiv","version":1}},"canonical_sha256":"9676a15b48938a785fb945b57106be843455f721d8f5e3c3e8e74acf6bdd8488","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9676a15b48938a785fb945b57106be843455f721d8f5e3c3e8e74acf6bdd8488","first_computed_at":"2026-05-18T01:22:44.986506Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:22:44.986506Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"9Kt5L49zWuXquZdNWcgVs+NZjvVOoA4n2Dn13Q9t3b6F3qyK9oRtOuP3WCeDEy1Y8N8oIdMNFAf+lXLIJ8GTDA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:22:44.987142Z","signed_message":"canonical_sha256_bytes"},"source_id":"1601.04458","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:79428f47e0135e0c2c42ebfa1dc3cb475e0f511b69351f4a4a425db227ad8baa","sha256:0c41df31c795bc2d0b76581b5eb486b4f8ce3a78e4d4ea16a8b64f8ded474431"],"state_sha256":"7bba693acf7716306c3ed5b23fc9ae43ccf0bdbf355f479b3a959679aa1251bd"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QGycOQn5jV0DPQelAqXDa6Rr2ua2GsDJeR/GNreLMwiyyfHrX+53/h1oYN0nvv7B/lM6ot1wdB1/0DeAmxhaAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-23T14:11:09.366550Z","bundle_sha256":"a2361bc2588775dd687eeef356592152a2cbadad1c6d7886b21325091920862d"}}