{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:TCTOTHRSWGLWND6M6VZIRA5PX2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7fc2415ceb56fe97f9d9c671d20bed75fd570e8620f091afaaefd13b886935ce","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2019-11-25T18:08:31Z","title_canon_sha256":"b9e54af3ebb55185e1e05bee7ac6fe4b37abd6e87c523072026c4ec50485a06c"},"schema_version":"1.0","source":{"id":"1911.11100","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1911.11100","created_at":"2026-07-05T02:31:58Z"},{"alias_kind":"arxiv_version","alias_value":"1911.11100v2","created_at":"2026-07-05T02:31:58Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1911.11100","created_at":"2026-07-05T02:31:58Z"},{"alias_kind":"pith_short_12","alias_value":"TCTOTHRSWGLW","created_at":"2026-07-05T02:31:58Z"},{"alias_kind":"pith_short_16","alias_value":"TCTOTHRSWGLWND6M","created_at":"2026-07-05T02:31:58Z"},{"alias_kind":"pith_short_8","alias_value":"TCTOTHRS","created_at":"2026-07-05T02:31:58Z"}],"graph_snapshots":[{"event_id":"sha256:7680d0120786a35b8ce9e9dfd6913769bd6044f0b8df43c25cafbe4dc2ab69c5","target":"graph","created_at":"2026-07-05T02:31:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1911.11100/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The HIV-1 integrase (IN) is a major target for the design of novel anti-HIV inhibitors. Among these, three inhibitors which embody a halobenzene ring derivative (HR) in their structures are presently used in clinics. High-resolution X-ray crystallography of the complexes of the IN-viral DNA transient complex bound to each of the three inhibitors showed in all cases the HR ring to interact within a confined zone of the viral DNA. The extension of its extracyclic CX bond is electron-depleted, owing to the existence of the \"sigma-hole\". It interacts favorably with the electron-rich rings of base ","authors_text":"Jean-Philip Piquemal, Krystel El Hage, L\\'ea El Khoury, Nohad Gresh, Perla El Darazi, Richard G. Maroun, Zeina Hobaika","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2019-11-25T18:08:31Z","title":"Quantum-Chemistry based design of halobenzene derivatives with augmented affinities for the HIV-1 viral G4/C16 base-pair"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1911.11100","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ea03996a8f76949a3fd24710d0ac4cd5d30f639c16203d4094069b10a8d56849","target":"record","created_at":"2026-07-05T02:31:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7fc2415ceb56fe97f9d9c671d20bed75fd570e8620f091afaaefd13b886935ce","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2019-11-25T18:08:31Z","title_canon_sha256":"b9e54af3ebb55185e1e05bee7ac6fe4b37abd6e87c523072026c4ec50485a06c"},"schema_version":"1.0","source":{"id":"1911.11100","kind":"arxiv","version":2}},"canonical_sha256":"98a6e99e32b197668fccf5728883afbe8d8b1da03d16f505a24cf8df5236641e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"98a6e99e32b197668fccf5728883afbe8d8b1da03d16f505a24cf8df5236641e","first_computed_at":"2026-07-05T02:31:58.509803Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:31:58.509803Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"xHXcQsVNLjhBpOEMcbnV2K6tIkd5LcM3L/7IK+N+y0121eHIIMUp9epegmb58TlNEmuC9SNErPPzBR4zZsQtCg==","signature_status":"signed_v1","signed_at":"2026-07-05T02:31:58.510270Z","signed_message":"canonical_sha256_bytes"},"source_id":"1911.11100","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ea03996a8f76949a3fd24710d0ac4cd5d30f639c16203d4094069b10a8d56849","sha256:7680d0120786a35b8ce9e9dfd6913769bd6044f0b8df43c25cafbe4dc2ab69c5"],"state_sha256":"be3f426df126fb2ed95db66e232a981debbbf2458b4f6b8a07f4adef4a4403f5"}