{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2009:TIALCVV7M5BS252GJIVRB3KF3H","short_pith_number":"pith:TIALCVV7","canonical_record":{"source":{"id":"0905.3353","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-05-20T16:55:01Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"0c38736032eb5c59f6c364572445701eab0dd5ca6538ecc17ba87e8d4a860b9c","abstract_canon_sha256":"e599d97b62fcc798ff4626c30d9ebc7a8bdaf99976d95f3881477e72e7aeaec5"},"schema_version":"1.0"},"canonical_sha256":"9a00b156bf67432d77464a2b10ed45d9c1068254f9c44bb2082621ef265295c4","source":{"kind":"arxiv","id":"0905.3353","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0905.3353","created_at":"2026-05-18T02:13:38Z"},{"alias_kind":"arxiv_version","alias_value":"0905.3353v1","created_at":"2026-05-18T02:13:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0905.3353","created_at":"2026-05-18T02:13:38Z"},{"alias_kind":"pith_short_12","alias_value":"TIALCVV7M5BS","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_16","alias_value":"TIALCVV7M5BS252G","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_8","alias_value":"TIALCVV7","created_at":"2026-05-18T12:26:01Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2009:TIALCVV7M5BS252GJIVRB3KF3H","target":"record","payload":{"canonical_record":{"source":{"id":"0905.3353","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-05-20T16:55:01Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"0c38736032eb5c59f6c364572445701eab0dd5ca6538ecc17ba87e8d4a860b9c","abstract_canon_sha256":"e599d97b62fcc798ff4626c30d9ebc7a8bdaf99976d95f3881477e72e7aeaec5"},"schema_version":"1.0"},"canonical_sha256":"9a00b156bf67432d77464a2b10ed45d9c1068254f9c44bb2082621ef265295c4","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:13:38.347550Z","signature_b64":"K0BWJTk6/Yjc7z7uCx+FsgyL6l7lqzxWC/C6wVZhomgWFJrHwwzT1cUrCSDBkd1J/Q89MFr1MCCAAfrTjovxAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9a00b156bf67432d77464a2b10ed45d9c1068254f9c44bb2082621ef265295c4","last_reissued_at":"2026-05-18T02:13:38.347160Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:13:38.347160Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0905.3353","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:13:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TkaeVavxJpCvyvDx3BwlyHjzK6u6O5N/PFAdzm6dW9zTJe2bex8VvtPmXNQbml26do/BqKr7qakV3SIBp0nXCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-22T03:17:18.034043Z"},"content_sha256":"3661223f2248e2d36f2392615a44f6710cbecbae85f110d3da491ff8dd8a81d0","schema_version":"1.0","event_id":"sha256:3661223f2248e2d36f2392615a44f6710cbecbae85f110d3da491ff8dd8a81d0"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2009:TIALCVV7M5BS252GJIVRB3KF3H","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Explicit kinetic heterogeneity: mechanistic models for interpretation of labeling data of heterogeneous cell populations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.PE","authors_text":"Jose Borghans, Rob De Boer, Vitaly V. Ganusov","submitted_at":"2009-05-20T16:55:01Z","abstract_excerpt":"Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system. Deuterium, in the form of deuterated glucose or heavy water, can be used to measure rates of proliferation and death of lymphocytes in vivo. Inferring these rates from labeling and delabeling curves has been subject to considerable debate with different groups suggesting different mathematical models for that purpose. We show that the three models that are most commonly used are in fact mathematically identical and differ only in their interpretation of th"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0905.3353","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:13:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HmrhLUrgwizVysnGwg9jZNIP1JL/qGtVz2OfbL+uj9qagankWx6cNgNddiWyncJPQPxfQZndCrMit1ttlssqDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-22T03:17:18.034403Z"},"content_sha256":"ccbba285d3145cb43cc7452f932e0ccfd899d16548cd2cd10037d0b5789dc50d","schema_version":"1.0","event_id":"sha256:ccbba285d3145cb43cc7452f932e0ccfd899d16548cd2cd10037d0b5789dc50d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/TIALCVV7M5BS252GJIVRB3KF3H/bundle.json","state_url":"https://pith.science/pith/TIALCVV7M5BS252GJIVRB3KF3H/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/TIALCVV7M5BS252GJIVRB3KF3H/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-22T03:17:18Z","links":{"resolver":"https://pith.science/pith/TIALCVV7M5BS252GJIVRB3KF3H","bundle":"https://pith.science/pith/TIALCVV7M5BS252GJIVRB3KF3H/bundle.json","state":"https://pith.science/pith/TIALCVV7M5BS252GJIVRB3KF3H/state.json","well_known_bundle":"https://pith.science/.well-known/pith/TIALCVV7M5BS252GJIVRB3KF3H/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:TIALCVV7M5BS252GJIVRB3KF3H","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e599d97b62fcc798ff4626c30d9ebc7a8bdaf99976d95f3881477e72e7aeaec5","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-05-20T16:55:01Z","title_canon_sha256":"0c38736032eb5c59f6c364572445701eab0dd5ca6538ecc17ba87e8d4a860b9c"},"schema_version":"1.0","source":{"id":"0905.3353","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0905.3353","created_at":"2026-05-18T02:13:38Z"},{"alias_kind":"arxiv_version","alias_value":"0905.3353v1","created_at":"2026-05-18T02:13:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0905.3353","created_at":"2026-05-18T02:13:38Z"},{"alias_kind":"pith_short_12","alias_value":"TIALCVV7M5BS","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_16","alias_value":"TIALCVV7M5BS252G","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_8","alias_value":"TIALCVV7","created_at":"2026-05-18T12:26:01Z"}],"graph_snapshots":[{"event_id":"sha256:ccbba285d3145cb43cc7452f932e0ccfd899d16548cd2cd10037d0b5789dc50d","target":"graph","created_at":"2026-05-18T02:13:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system. Deuterium, in the form of deuterated glucose or heavy water, can be used to measure rates of proliferation and death of lymphocytes in vivo. Inferring these rates from labeling and delabeling curves has been subject to considerable debate with different groups suggesting different mathematical models for that purpose. We show that the three models that are most commonly used are in fact mathematically identical and differ only in their interpretation of th","authors_text":"Jose Borghans, Rob De Boer, Vitaly V. Ganusov","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-05-20T16:55:01Z","title":"Explicit kinetic heterogeneity: mechanistic models for interpretation of labeling data of heterogeneous cell populations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0905.3353","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3661223f2248e2d36f2392615a44f6710cbecbae85f110d3da491ff8dd8a81d0","target":"record","created_at":"2026-05-18T02:13:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e599d97b62fcc798ff4626c30d9ebc7a8bdaf99976d95f3881477e72e7aeaec5","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2009-05-20T16:55:01Z","title_canon_sha256":"0c38736032eb5c59f6c364572445701eab0dd5ca6538ecc17ba87e8d4a860b9c"},"schema_version":"1.0","source":{"id":"0905.3353","kind":"arxiv","version":1}},"canonical_sha256":"9a00b156bf67432d77464a2b10ed45d9c1068254f9c44bb2082621ef265295c4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9a00b156bf67432d77464a2b10ed45d9c1068254f9c44bb2082621ef265295c4","first_computed_at":"2026-05-18T02:13:38.347160Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:13:38.347160Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"K0BWJTk6/Yjc7z7uCx+FsgyL6l7lqzxWC/C6wVZhomgWFJrHwwzT1cUrCSDBkd1J/Q89MFr1MCCAAfrTjovxAg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:13:38.347550Z","signed_message":"canonical_sha256_bytes"},"source_id":"0905.3353","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3661223f2248e2d36f2392615a44f6710cbecbae85f110d3da491ff8dd8a81d0","sha256:ccbba285d3145cb43cc7452f932e0ccfd899d16548cd2cd10037d0b5789dc50d"],"state_sha256":"97d9c1382283fbc08a6ae65d34a78f815601f86471104559b7e49de648b32864"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PDVhDW3O6b6yf8qV7pVTKRM8q5A2SGdSb3eKCmLqOuHO50X0imUb4XV5fFfiGLpSvdz+nAn+X/47PPOAD25mAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-22T03:17:18.036390Z","bundle_sha256":"9fbdf309379d6214f17627042b298a04953f7916a48a2a3104bc3215942248b4"}}