{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:TJLJ5I4MW7V7VEN4LDBTULUQJR","short_pith_number":"pith:TJLJ5I4M","canonical_record":{"source":{"id":"1409.7827","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-09-27T18:35:34Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"9cfec027bcb30a7ea60f95fd19a2b53541c59805bf5215ea40ce5bea935c590c","abstract_canon_sha256":"1885591ea3b4a57a4a3325888ae96b2377d2b0713f89ff56dbffb7d778fe1123"},"schema_version":"1.0"},"canonical_sha256":"9a569ea38cb7ebfa91bc58c33a2e904c49898ce652b9e2bb2d4bf80fb5499a45","source":{"kind":"arxiv","id":"1409.7827","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1409.7827","created_at":"2026-05-18T02:41:40Z"},{"alias_kind":"arxiv_version","alias_value":"1409.7827v1","created_at":"2026-05-18T02:41:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1409.7827","created_at":"2026-05-18T02:41:40Z"},{"alias_kind":"pith_short_12","alias_value":"TJLJ5I4MW7V7","created_at":"2026-05-18T12:28:49Z"},{"alias_kind":"pith_short_16","alias_value":"TJLJ5I4MW7V7VEN4","created_at":"2026-05-18T12:28:49Z"},{"alias_kind":"pith_short_8","alias_value":"TJLJ5I4M","created_at":"2026-05-18T12:28:49Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:TJLJ5I4MW7V7VEN4LDBTULUQJR","target":"record","payload":{"canonical_record":{"source":{"id":"1409.7827","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-09-27T18:35:34Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"9cfec027bcb30a7ea60f95fd19a2b53541c59805bf5215ea40ce5bea935c590c","abstract_canon_sha256":"1885591ea3b4a57a4a3325888ae96b2377d2b0713f89ff56dbffb7d778fe1123"},"schema_version":"1.0"},"canonical_sha256":"9a569ea38cb7ebfa91bc58c33a2e904c49898ce652b9e2bb2d4bf80fb5499a45","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:41:40.471902Z","signature_b64":"EWj8fQq3MTJtXNxzUD4pwlbR5Q0l6MSO4K4gHlt4RYZ5DToveEYx6aHjzCO1eGizgjtQK1IVuke2fYYDpKx4DQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9a569ea38cb7ebfa91bc58c33a2e904c49898ce652b9e2bb2d4bf80fb5499a45","last_reissued_at":"2026-05-18T02:41:40.471291Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:41:40.471291Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1409.7827","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:41:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Ex2O3uLFB/C3g6+xp5qHKdVu5C346K9zMGtXv3FJmZy8fyceVvEucHDA7kDeav171PERjQc+EUYYSOpU8nMMAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T21:51:45.585547Z"},"content_sha256":"146a1078fa2406015f5184e41a2f270cb34c8e72e8afcd31c4abd9f4e263c1f3","schema_version":"1.0","event_id":"sha256:146a1078fa2406015f5184e41a2f270cb34c8e72e8afcd31c4abd9f4e263c1f3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:TJLJ5I4MW7V7VEN4LDBTULUQJR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A Statistical Approach to Identifying Significant Transgenerational Methylation Changes","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.QM","authors_text":"Bai Zhang, Guoqiang Yu, Ye Tian, Yi Fu, Yue Wang","submitted_at":"2014-09-27T18:35:34Z","abstract_excerpt":"Epigenetic aberrations have profound effects on phenotypic output. Genome wide methylation alterations are inheritable to pass down the aberrations through multiple generations. We developed a statistical method, Genome-wide Identification of Significant Methylation Alteration, GISAIM, to study the significant transgenerational methylation changes. GISAIM finds the significant methylation aberrations that are inherited through multiple generations. In a concrete biological study, we investigated whether exposing pregnant rats (F0) to a high fat (HF) diet throughout pregnancy or ethinyl estradi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1409.7827","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:41:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6FUGYIndO6s7nOmmQKs2/eDGNoH16aSU584snytWWuQcJ/x7r14nrOodVUuVEZADpncGYI3tdbmxKV1mRxJADg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T21:51:45.586194Z"},"content_sha256":"5704b1f9f3f3524d71881f974d2e6834c1648a1db8f42ff8bf2e9cc8b30179c7","schema_version":"1.0","event_id":"sha256:5704b1f9f3f3524d71881f974d2e6834c1648a1db8f42ff8bf2e9cc8b30179c7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/TJLJ5I4MW7V7VEN4LDBTULUQJR/bundle.json","state_url":"https://pith.science/pith/TJLJ5I4MW7V7VEN4LDBTULUQJR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/TJLJ5I4MW7V7VEN4LDBTULUQJR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-25T21:51:45Z","links":{"resolver":"https://pith.science/pith/TJLJ5I4MW7V7VEN4LDBTULUQJR","bundle":"https://pith.science/pith/TJLJ5I4MW7V7VEN4LDBTULUQJR/bundle.json","state":"https://pith.science/pith/TJLJ5I4MW7V7VEN4LDBTULUQJR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/TJLJ5I4MW7V7VEN4LDBTULUQJR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:TJLJ5I4MW7V7VEN4LDBTULUQJR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1885591ea3b4a57a4a3325888ae96b2377d2b0713f89ff56dbffb7d778fe1123","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-09-27T18:35:34Z","title_canon_sha256":"9cfec027bcb30a7ea60f95fd19a2b53541c59805bf5215ea40ce5bea935c590c"},"schema_version":"1.0","source":{"id":"1409.7827","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1409.7827","created_at":"2026-05-18T02:41:40Z"},{"alias_kind":"arxiv_version","alias_value":"1409.7827v1","created_at":"2026-05-18T02:41:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1409.7827","created_at":"2026-05-18T02:41:40Z"},{"alias_kind":"pith_short_12","alias_value":"TJLJ5I4MW7V7","created_at":"2026-05-18T12:28:49Z"},{"alias_kind":"pith_short_16","alias_value":"TJLJ5I4MW7V7VEN4","created_at":"2026-05-18T12:28:49Z"},{"alias_kind":"pith_short_8","alias_value":"TJLJ5I4M","created_at":"2026-05-18T12:28:49Z"}],"graph_snapshots":[{"event_id":"sha256:5704b1f9f3f3524d71881f974d2e6834c1648a1db8f42ff8bf2e9cc8b30179c7","target":"graph","created_at":"2026-05-18T02:41:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Epigenetic aberrations have profound effects on phenotypic output. Genome wide methylation alterations are inheritable to pass down the aberrations through multiple generations. We developed a statistical method, Genome-wide Identification of Significant Methylation Alteration, GISAIM, to study the significant transgenerational methylation changes. GISAIM finds the significant methylation aberrations that are inherited through multiple generations. In a concrete biological study, we investigated whether exposing pregnant rats (F0) to a high fat (HF) diet throughout pregnancy or ethinyl estradi","authors_text":"Bai Zhang, Guoqiang Yu, Ye Tian, Yi Fu, Yue Wang","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-09-27T18:35:34Z","title":"A Statistical Approach to Identifying Significant Transgenerational Methylation Changes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1409.7827","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:146a1078fa2406015f5184e41a2f270cb34c8e72e8afcd31c4abd9f4e263c1f3","target":"record","created_at":"2026-05-18T02:41:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1885591ea3b4a57a4a3325888ae96b2377d2b0713f89ff56dbffb7d778fe1123","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-09-27T18:35:34Z","title_canon_sha256":"9cfec027bcb30a7ea60f95fd19a2b53541c59805bf5215ea40ce5bea935c590c"},"schema_version":"1.0","source":{"id":"1409.7827","kind":"arxiv","version":1}},"canonical_sha256":"9a569ea38cb7ebfa91bc58c33a2e904c49898ce652b9e2bb2d4bf80fb5499a45","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9a569ea38cb7ebfa91bc58c33a2e904c49898ce652b9e2bb2d4bf80fb5499a45","first_computed_at":"2026-05-18T02:41:40.471291Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:41:40.471291Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"EWj8fQq3MTJtXNxzUD4pwlbR5Q0l6MSO4K4gHlt4RYZ5DToveEYx6aHjzCO1eGizgjtQK1IVuke2fYYDpKx4DQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:41:40.471902Z","signed_message":"canonical_sha256_bytes"},"source_id":"1409.7827","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:146a1078fa2406015f5184e41a2f270cb34c8e72e8afcd31c4abd9f4e263c1f3","sha256:5704b1f9f3f3524d71881f974d2e6834c1648a1db8f42ff8bf2e9cc8b30179c7"],"state_sha256":"90190a24a188add468168f9e894f7ecafecd1ba561ac7d85be59ca354f161516"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"SOcY1fJimW3vLVpkkL0Q+DRt/XK0pECbrjK+0OQFfCKJ/16GP1IRv09Lga6DgIUEadwN7ZgEOu7AKjAWMdBoBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-25T21:51:45.589900Z","bundle_sha256":"b224b3e4ae034c187f07ec331339a8c7e3b3aebf39e78a9304880b5ae43ff994"}}