{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:TO5WUM7LF43ZB4GBZXZLZ5PA47","short_pith_number":"pith:TO5WUM7L","canonical_record":{"source":{"id":"1509.03107","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-10T11:35:14Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"a56e15e40b1ad4e1a102db0f0cde46cb10c9125a3334eceb799f255ef91d3233","abstract_canon_sha256":"c40b3dd7fecde90f7cb8b1c093d35d2e877c941a2f1b88f647264cdb1e80d758"},"schema_version":"1.0"},"canonical_sha256":"9bbb6a33eb2f3790f0c1cdf2bcf5e0e7cc0468f4767c61bfbf57cb5a13c15217","source":{"kind":"arxiv","id":"1509.03107","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.03107","created_at":"2026-05-18T01:18:43Z"},{"alias_kind":"arxiv_version","alias_value":"1509.03107v1","created_at":"2026-05-18T01:18:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.03107","created_at":"2026-05-18T01:18:43Z"},{"alias_kind":"pith_short_12","alias_value":"TO5WUM7LF43Z","created_at":"2026-05-18T12:29:42Z"},{"alias_kind":"pith_short_16","alias_value":"TO5WUM7LF43ZB4GB","created_at":"2026-05-18T12:29:42Z"},{"alias_kind":"pith_short_8","alias_value":"TO5WUM7L","created_at":"2026-05-18T12:29:42Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:TO5WUM7LF43ZB4GBZXZLZ5PA47","target":"record","payload":{"canonical_record":{"source":{"id":"1509.03107","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-10T11:35:14Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"a56e15e40b1ad4e1a102db0f0cde46cb10c9125a3334eceb799f255ef91d3233","abstract_canon_sha256":"c40b3dd7fecde90f7cb8b1c093d35d2e877c941a2f1b88f647264cdb1e80d758"},"schema_version":"1.0"},"canonical_sha256":"9bbb6a33eb2f3790f0c1cdf2bcf5e0e7cc0468f4767c61bfbf57cb5a13c15217","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:18:43.160168Z","signature_b64":"jTS7rRbu0WC79jjeZ9DJhK0Pk3+pSjZhK4MzzbrF+k/L09tiFWb7uQmn238w68e6hdcdaZn2YeDT9c+MBhwyAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9bbb6a33eb2f3790f0c1cdf2bcf5e0e7cc0468f4767c61bfbf57cb5a13c15217","last_reissued_at":"2026-05-18T01:18:43.158856Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:18:43.158856Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1509.03107","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:18:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"K/mmRDUv/d5hTWga5G46A5sYueqbcvE4E8ffS7/lfsOy9NfeSG16+YJ/ciBamI2qIihbMLOn+2boNqbdAGuhDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T03:59:41.848214Z"},"content_sha256":"65fb45c01b256347a47672225779d903c7fe588a9e9aad1a40b0a396942f23fb","schema_version":"1.0","event_id":"sha256:65fb45c01b256347a47672225779d903c7fe588a9e9aad1a40b0a396942f23fb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:TO5WUM7LF43ZB4GBZXZLZ5PA47","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.SC","authors_text":"Christoph Braeuchle, Ernst Wagner, Hanna Engelke, Karin Moeller, Katharina Mueller, Thomas Bein","submitted_at":"2015-09-10T11:35:14Z","abstract_excerpt":"A new general route for siRNA delivery is presented combining porous core-shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica nanoparticles (MSN) with orthogonal core-shell surface chemistry was investigated as a function of pore-size, pore morphology, surface properties and pH. Very high siRNA loading capacities of up to 380 microg/mg MSN were obtained with charge-matched amino-functionalized mesoporous cores, and release profiles show up to 80% siRNA elution after 24 h. We demonstr"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.03107","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:18:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ghTgOaM8iBTbFg5k0TL3cNDc/neLXLh56GD9W1d2JOQGuQ3rpS0SmApa0iJ7hmjf49hQY1/VcXII7lXpqr2MCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T03:59:41.848603Z"},"content_sha256":"09f6a66c784ee0b623d3572d43e375e513f65d0e7b649ac007c6f8104e235de6","schema_version":"1.0","event_id":"sha256:09f6a66c784ee0b623d3572d43e375e513f65d0e7b649ac007c6f8104e235de6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/TO5WUM7LF43ZB4GBZXZLZ5PA47/bundle.json","state_url":"https://pith.science/pith/TO5WUM7LF43ZB4GBZXZLZ5PA47/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/TO5WUM7LF43ZB4GBZXZLZ5PA47/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T03:59:41Z","links":{"resolver":"https://pith.science/pith/TO5WUM7LF43ZB4GBZXZLZ5PA47","bundle":"https://pith.science/pith/TO5WUM7LF43ZB4GBZXZLZ5PA47/bundle.json","state":"https://pith.science/pith/TO5WUM7LF43ZB4GBZXZLZ5PA47/state.json","well_known_bundle":"https://pith.science/.well-known/pith/TO5WUM7LF43ZB4GBZXZLZ5PA47/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:TO5WUM7LF43ZB4GBZXZLZ5PA47","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c40b3dd7fecde90f7cb8b1c093d35d2e877c941a2f1b88f647264cdb1e80d758","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-10T11:35:14Z","title_canon_sha256":"a56e15e40b1ad4e1a102db0f0cde46cb10c9125a3334eceb799f255ef91d3233"},"schema_version":"1.0","source":{"id":"1509.03107","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.03107","created_at":"2026-05-18T01:18:43Z"},{"alias_kind":"arxiv_version","alias_value":"1509.03107v1","created_at":"2026-05-18T01:18:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.03107","created_at":"2026-05-18T01:18:43Z"},{"alias_kind":"pith_short_12","alias_value":"TO5WUM7LF43Z","created_at":"2026-05-18T12:29:42Z"},{"alias_kind":"pith_short_16","alias_value":"TO5WUM7LF43ZB4GB","created_at":"2026-05-18T12:29:42Z"},{"alias_kind":"pith_short_8","alias_value":"TO5WUM7L","created_at":"2026-05-18T12:29:42Z"}],"graph_snapshots":[{"event_id":"sha256:09f6a66c784ee0b623d3572d43e375e513f65d0e7b649ac007c6f8104e235de6","target":"graph","created_at":"2026-05-18T01:18:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A new general route for siRNA delivery is presented combining porous core-shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica nanoparticles (MSN) with orthogonal core-shell surface chemistry was investigated as a function of pore-size, pore morphology, surface properties and pH. Very high siRNA loading capacities of up to 380 microg/mg MSN were obtained with charge-matched amino-functionalized mesoporous cores, and release profiles show up to 80% siRNA elution after 24 h. We demonstr","authors_text":"Christoph Braeuchle, Ernst Wagner, Hanna Engelke, Karin Moeller, Katharina Mueller, Thomas Bein","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-10T11:35:14Z","title":"Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.03107","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:65fb45c01b256347a47672225779d903c7fe588a9e9aad1a40b0a396942f23fb","target":"record","created_at":"2026-05-18T01:18:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c40b3dd7fecde90f7cb8b1c093d35d2e877c941a2f1b88f647264cdb1e80d758","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-09-10T11:35:14Z","title_canon_sha256":"a56e15e40b1ad4e1a102db0f0cde46cb10c9125a3334eceb799f255ef91d3233"},"schema_version":"1.0","source":{"id":"1509.03107","kind":"arxiv","version":1}},"canonical_sha256":"9bbb6a33eb2f3790f0c1cdf2bcf5e0e7cc0468f4767c61bfbf57cb5a13c15217","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9bbb6a33eb2f3790f0c1cdf2bcf5e0e7cc0468f4767c61bfbf57cb5a13c15217","first_computed_at":"2026-05-18T01:18:43.158856Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:18:43.158856Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"jTS7rRbu0WC79jjeZ9DJhK0Pk3+pSjZhK4MzzbrF+k/L09tiFWb7uQmn238w68e6hdcdaZn2YeDT9c+MBhwyAA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:18:43.160168Z","signed_message":"canonical_sha256_bytes"},"source_id":"1509.03107","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:65fb45c01b256347a47672225779d903c7fe588a9e9aad1a40b0a396942f23fb","sha256:09f6a66c784ee0b623d3572d43e375e513f65d0e7b649ac007c6f8104e235de6"],"state_sha256":"cf4636a922a3cca55e077da134f3bfdaa78b8a04bc691bb21841f901abc5c000"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"yVlh2fyEcGRjKV7hXdPNynwTobcctzfOWBVkrtYtL1+vM0WMmZpz9Vfgb6PU7X4OEDq+kHLpnQaxXwDnrUQNAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T03:59:41.850885Z","bundle_sha256":"6bb5b03463a02d06adf0e8ad55a8c760f02ac6a57704d3c51107c836cfec86e8"}}