{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:TROLU3GIXIBZX736BD7E2PS24R","short_pith_number":"pith:TROLU3GI","canonical_record":{"source":{"id":"1908.03336","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2019-08-09T07:00:08Z","cross_cats_sorted":[],"title_canon_sha256":"ca358ac9f039e3f50736d132afabca97f56639503db0dfe8d7272cda46e3c5dd","abstract_canon_sha256":"c247c07c480d383c893ebdd2c032565e29a3ebc910af5e70413c3c8a05816690"},"schema_version":"1.0"},"canonical_sha256":"9c5cba6cc8ba039bff7e08fe4d3e5ae464686d2d6e9c8f4c2e5f89b7bedad78f","source":{"kind":"arxiv","id":"1908.03336","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.03336","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"arxiv_version","alias_value":"1908.03336v1","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.03336","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"pith_short_12","alias_value":"TROLU3GIXIBZ","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"pith_short_16","alias_value":"TROLU3GIXIBZX736","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"pith_short_8","alias_value":"TROLU3GI","created_at":"2026-07-04T23:52:39Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:TROLU3GIXIBZX736BD7E2PS24R","target":"record","payload":{"canonical_record":{"source":{"id":"1908.03336","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2019-08-09T07:00:08Z","cross_cats_sorted":[],"title_canon_sha256":"ca358ac9f039e3f50736d132afabca97f56639503db0dfe8d7272cda46e3c5dd","abstract_canon_sha256":"c247c07c480d383c893ebdd2c032565e29a3ebc910af5e70413c3c8a05816690"},"schema_version":"1.0"},"canonical_sha256":"9c5cba6cc8ba039bff7e08fe4d3e5ae464686d2d6e9c8f4c2e5f89b7bedad78f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-04T23:52:39.057615Z","signature_b64":"SXr4FLKh+sCDjtgaN6GtSo9K8kERdTBwStTar/PG43LtMfjKdASlotMbvEZxG8Q/g3r4LtpxoaqqWDjdBwmeAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9c5cba6cc8ba039bff7e08fe4d3e5ae464686d2d6e9c8f4c2e5f89b7bedad78f","last_reissued_at":"2026-07-04T23:52:39.057240Z","signature_status":"signed_v1","first_computed_at":"2026-07-04T23:52:39.057240Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1908.03336","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T23:52:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NfT2FoECe/cuG6kHyRL/E7arZhyyaVAQ3SBjreU4FCmAeE3V0CK75jRuAWFs5ShuyRR2JCvP4HnWq0BIL1jkDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T13:31:20.616960Z"},"content_sha256":"e42ae76cc7b2dc9379fc6e836e393f9a41b0295304acfbe8acc5eea94526fcee","schema_version":"1.0","event_id":"sha256:e42ae76cc7b2dc9379fc6e836e393f9a41b0295304acfbe8acc5eea94526fcee"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:TROLU3GIXIBZX736BD7E2PS24R","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A new pharmacological preconditioning-based target: from drosophila to kidney transplantation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Michel Tauc, Miled Bourourou (IPMC), Nicolas Blondeau (IPMC), Nicolas Melis (IBV), S\\'ebastien Giraud (LPS), Thierry Hauet (IRTOMIT)","submitted_at":"2019-08-09T07:00:08Z","abstract_excerpt":"One of the biggest challenges in medicine is to dampen the pathophysiological stress induced by an episode of ischemia. Such stress, due to various pathological or clinical situations, follows a restriction in blood and oxygen supply to tissue, causing a shortage of oxygen and nutrients that are required for cellular metabolism. Ischemia can cause irreversible damage to target tissue leading to a poor physiological recovery outcome for the patient. Contrariwise, preconditioning by brief periods of ischemia has been shown in multiple organs to confer tolerance against subsequent normally lethal"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.03336","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1908.03336/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T23:52:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OOti0BvadI7PjeCb8m+50ZbPdfn/ycwHzsebT7Ier+CEoxfUpZ0QM6T4v8qRro3U+l7R6/YYHgQeZHenl85vCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T13:31:20.617877Z"},"content_sha256":"9dd0125b3b00ac65bce6885a2ebb9c43f141ad8e9250bb9889db5358e1148c54","schema_version":"1.0","event_id":"sha256:9dd0125b3b00ac65bce6885a2ebb9c43f141ad8e9250bb9889db5358e1148c54"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/TROLU3GIXIBZX736BD7E2PS24R/bundle.json","state_url":"https://pith.science/pith/TROLU3GIXIBZX736BD7E2PS24R/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/TROLU3GIXIBZX736BD7E2PS24R/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-16T13:31:20Z","links":{"resolver":"https://pith.science/pith/TROLU3GIXIBZX736BD7E2PS24R","bundle":"https://pith.science/pith/TROLU3GIXIBZX736BD7E2PS24R/bundle.json","state":"https://pith.science/pith/TROLU3GIXIBZX736BD7E2PS24R/state.json","well_known_bundle":"https://pith.science/.well-known/pith/TROLU3GIXIBZX736BD7E2PS24R/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:TROLU3GIXIBZX736BD7E2PS24R","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c247c07c480d383c893ebdd2c032565e29a3ebc910af5e70413c3c8a05816690","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2019-08-09T07:00:08Z","title_canon_sha256":"ca358ac9f039e3f50736d132afabca97f56639503db0dfe8d7272cda46e3c5dd"},"schema_version":"1.0","source":{"id":"1908.03336","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.03336","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"arxiv_version","alias_value":"1908.03336v1","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.03336","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"pith_short_12","alias_value":"TROLU3GIXIBZ","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"pith_short_16","alias_value":"TROLU3GIXIBZX736","created_at":"2026-07-04T23:52:39Z"},{"alias_kind":"pith_short_8","alias_value":"TROLU3GI","created_at":"2026-07-04T23:52:39Z"}],"graph_snapshots":[{"event_id":"sha256:9dd0125b3b00ac65bce6885a2ebb9c43f141ad8e9250bb9889db5358e1148c54","target":"graph","created_at":"2026-07-04T23:52:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1908.03336/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"One of the biggest challenges in medicine is to dampen the pathophysiological stress induced by an episode of ischemia. Such stress, due to various pathological or clinical situations, follows a restriction in blood and oxygen supply to tissue, causing a shortage of oxygen and nutrients that are required for cellular metabolism. Ischemia can cause irreversible damage to target tissue leading to a poor physiological recovery outcome for the patient. Contrariwise, preconditioning by brief periods of ischemia has been shown in multiple organs to confer tolerance against subsequent normally lethal","authors_text":"Michel Tauc, Miled Bourourou (IPMC), Nicolas Blondeau (IPMC), Nicolas Melis (IBV), S\\'ebastien Giraud (LPS), Thierry Hauet (IRTOMIT)","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2019-08-09T07:00:08Z","title":"A new pharmacological preconditioning-based target: from drosophila to kidney transplantation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.03336","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e42ae76cc7b2dc9379fc6e836e393f9a41b0295304acfbe8acc5eea94526fcee","target":"record","created_at":"2026-07-04T23:52:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c247c07c480d383c893ebdd2c032565e29a3ebc910af5e70413c3c8a05816690","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2019-08-09T07:00:08Z","title_canon_sha256":"ca358ac9f039e3f50736d132afabca97f56639503db0dfe8d7272cda46e3c5dd"},"schema_version":"1.0","source":{"id":"1908.03336","kind":"arxiv","version":1}},"canonical_sha256":"9c5cba6cc8ba039bff7e08fe4d3e5ae464686d2d6e9c8f4c2e5f89b7bedad78f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9c5cba6cc8ba039bff7e08fe4d3e5ae464686d2d6e9c8f4c2e5f89b7bedad78f","first_computed_at":"2026-07-04T23:52:39.057240Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-04T23:52:39.057240Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"SXr4FLKh+sCDjtgaN6GtSo9K8kERdTBwStTar/PG43LtMfjKdASlotMbvEZxG8Q/g3r4LtpxoaqqWDjdBwmeAA==","signature_status":"signed_v1","signed_at":"2026-07-04T23:52:39.057615Z","signed_message":"canonical_sha256_bytes"},"source_id":"1908.03336","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e42ae76cc7b2dc9379fc6e836e393f9a41b0295304acfbe8acc5eea94526fcee","sha256:9dd0125b3b00ac65bce6885a2ebb9c43f141ad8e9250bb9889db5358e1148c54"],"state_sha256":"a15b5353b46ef882f67544b9253df724f7bf67e2b2d8e47509bdb9498355b8ab"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"odRBDB+HUgQxTqDsMT9P98weKMONpsnt26aVbGtUl8wxE1KMTRykEDAB+hqr2vhPo5fimlgaWtFbnGlaWWflBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-16T13:31:20.624574Z","bundle_sha256":"7c44fe5f641dabd72e0374788897500a2c8b964d498e7f4ceede12fcd7b5329b"}}