{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:TSBEQKN3KIEY3KUHL3IR4BHVCC","short_pith_number":"pith:TSBEQKN3","schema_version":"1.0","canonical_sha256":"9c824829bb52098daa875ed11e04f510963ab3614a3669d60a20659d6741a63b","source":{"kind":"arxiv","id":"1509.06778","version":1},"attestation_state":"computed","paper":{"title":"On the impact of Masking and Blocking Hypotheses for measuring efficacy of new tuberculosis vaccines","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Carlos Mart\\'in, Dessislava Marinova, Joaqu\\'in Sanz, Sergio Arregui, Yamir Moreno","submitted_at":"2015-09-22T20:47:07Z","abstract_excerpt":"Over the past 60 years, the Mycobacterium bovis bacille Calmette-Gu\\'erin (BCG) has been used worldwide to prevent tuberculosis (TB). However, BCG has shown a very variable efficacy in different trials, showing a wide range of protection in adults against pulmonary TB. Previous studies indicate that this failure is related to pre-existing immune response to antigens that are common to environmental sources of mycobacterial antigens and Mycobacterium tuberculosis. Specifically, two different mechanisms have been hypothesized: the masking, (previous sensitization confers some level of protection"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1509.06778","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2015-09-22T20:47:07Z","cross_cats_sorted":[],"title_canon_sha256":"30e2a8bcfe8aef93da1e3d2182b21538c0020f2eb66cef54af13dc285d4bc76a","abstract_canon_sha256":"eb1e33c338c6dfe6fa88b65bd1340090c2bcca1866c68ffdeb38c4942e41f508"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:32:18.062752Z","signature_b64":"V9MlyUM159L4NqznJGbZQ2yC8/QQebYDM63ThpDRh5aYyFVqBxxqMtgjqGvFj2CdKYJy17d6hA7teHyzarsmAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9c824829bb52098daa875ed11e04f510963ab3614a3669d60a20659d6741a63b","last_reissued_at":"2026-05-18T01:32:18.062116Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:32:18.062116Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"On the impact of Masking and Blocking Hypotheses for measuring efficacy of new tuberculosis vaccines","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Carlos Mart\\'in, Dessislava Marinova, Joaqu\\'in Sanz, Sergio Arregui, Yamir Moreno","submitted_at":"2015-09-22T20:47:07Z","abstract_excerpt":"Over the past 60 years, the Mycobacterium bovis bacille Calmette-Gu\\'erin (BCG) has been used worldwide to prevent tuberculosis (TB). However, BCG has shown a very variable efficacy in different trials, showing a wide range of protection in adults against pulmonary TB. Previous studies indicate that this failure is related to pre-existing immune response to antigens that are common to environmental sources of mycobacterial antigens and Mycobacterium tuberculosis. Specifically, two different mechanisms have been hypothesized: the masking, (previous sensitization confers some level of protection"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.06778","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1509.06778","created_at":"2026-05-18T01:32:18.062186+00:00"},{"alias_kind":"arxiv_version","alias_value":"1509.06778v1","created_at":"2026-05-18T01:32:18.062186+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.06778","created_at":"2026-05-18T01:32:18.062186+00:00"},{"alias_kind":"pith_short_12","alias_value":"TSBEQKN3KIEY","created_at":"2026-05-18T12:29:42.218222+00:00"},{"alias_kind":"pith_short_16","alias_value":"TSBEQKN3KIEY3KUH","created_at":"2026-05-18T12:29:42.218222+00:00"},{"alias_kind":"pith_short_8","alias_value":"TSBEQKN3","created_at":"2026-05-18T12:29:42.218222+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC","json":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC.json","graph_json":"https://pith.science/api/pith-number/TSBEQKN3KIEY3KUHL3IR4BHVCC/graph.json","events_json":"https://pith.science/api/pith-number/TSBEQKN3KIEY3KUHL3IR4BHVCC/events.json","paper":"https://pith.science/paper/TSBEQKN3"},"agent_actions":{"view_html":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC","download_json":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC.json","view_paper":"https://pith.science/paper/TSBEQKN3","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1509.06778&json=true","fetch_graph":"https://pith.science/api/pith-number/TSBEQKN3KIEY3KUHL3IR4BHVCC/graph.json","fetch_events":"https://pith.science/api/pith-number/TSBEQKN3KIEY3KUHL3IR4BHVCC/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC/action/timestamp_anchor","attest_storage":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC/action/storage_attestation","attest_author":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC/action/author_attestation","sign_citation":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC/action/citation_signature","submit_replication":"https://pith.science/pith/TSBEQKN3KIEY3KUHL3IR4BHVCC/action/replication_record"}},"created_at":"2026-05-18T01:32:18.062186+00:00","updated_at":"2026-05-18T01:32:18.062186+00:00"}