{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:TSQAJEL3CN5C7KPREQP7LW45SP","short_pith_number":"pith:TSQAJEL3","canonical_record":{"source":{"id":"2204.10182","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-03-31T09:39:57Z","cross_cats_sorted":["quant-ph"],"title_canon_sha256":"e14fc8d2d8c6e5066206c6ef382f15e38b89a6c47c673f07275322ed402a84ea","abstract_canon_sha256":"6f27f5cdb982b139f2a551e886a739bc0454e182a48a65fad9bf4578ae1452db"},"schema_version":"1.0"},"canonical_sha256":"9ca004917b137a2fa9f1241ff5db9d93f3aa9bc528515fb5a9ee93cf8502bf29","source":{"kind":"arxiv","id":"2204.10182","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2204.10182","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"arxiv_version","alias_value":"2204.10182v1","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2204.10182","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"pith_short_12","alias_value":"TSQAJEL3CN5C","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"pith_short_16","alias_value":"TSQAJEL3CN5C7KPR","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"pith_short_8","alias_value":"TSQAJEL3","created_at":"2026-07-05T04:45:48Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:TSQAJEL3CN5C7KPREQP7LW45SP","target":"record","payload":{"canonical_record":{"source":{"id":"2204.10182","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-03-31T09:39:57Z","cross_cats_sorted":["quant-ph"],"title_canon_sha256":"e14fc8d2d8c6e5066206c6ef382f15e38b89a6c47c673f07275322ed402a84ea","abstract_canon_sha256":"6f27f5cdb982b139f2a551e886a739bc0454e182a48a65fad9bf4578ae1452db"},"schema_version":"1.0"},"canonical_sha256":"9ca004917b137a2fa9f1241ff5db9d93f3aa9bc528515fb5a9ee93cf8502bf29","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T04:45:48.569729Z","signature_b64":"H26PZ1NNiDgG+a48KENc3pJ9H148MAmowCrbS0BHrhQql59UKiI+lF7GNzY+f1aAZwVO/ejCHzd0Niqy9h1uBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9ca004917b137a2fa9f1241ff5db9d93f3aa9bc528515fb5a9ee93cf8502bf29","last_reissued_at":"2026-07-05T04:45:48.569241Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T04:45:48.569241Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2204.10182","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:45:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TN1b3egatSgzcYBbfqG+aGn7BpdWSyXCxGWAtThHFbOIcWK1nDXoFlgf2+3D/FLSGWru4jFqfhMjh2sjgnvVBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T08:06:29.184191Z"},"content_sha256":"1f82f5b4b10d242bbddea9ab37438e646a93762563d061d1923f657da2f7adb6","schema_version":"1.0","event_id":"sha256:1f82f5b4b10d242bbddea9ab37438e646a93762563d061d1923f657da2f7adb6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:TSQAJEL3CN5C7KPREQP7LW45SP","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Nanodiamond quantum sensors reveal temperature variation associated to hippocampal neurons firing","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["quant-ph"],"primary_cat":"q-bio.NC","authors_text":"A. Marcantoni, E. Bernardi, E. Moreva, F. Picollo, G. Petrini, G. Tomagra, I.P. Degiovanni, K. Kvakova, M. Genovese, P. Cigler, P. Traina, V. Carabelli","submitted_at":"2022-03-31T09:39:57Z","abstract_excerpt":"Temperature is one of the most relevant parameters for the regulation of intracellular processes. Measuring localized subcellular temperature gradients is fundamental for a deeper understanding of cell function, such as the genesis of action potentials, and cell metabolism. Here, we detect for the first time temperature variations (1{\\deg}C) associated with potentiation and depletion of neuronal firing, exploiting a nanoscale thermometer based on optically detected magnetic resonance in nanodiamonds. Our results provide a tool for assessing neuronal spiking activity under physiological and pat"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2204.10182","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2204.10182/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:45:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QgcQnBmyrPYeYfGuwxfAl3iAEjcKRbPe/IAdE3gQR41TPiAki5MOwmmCXyRGBkarsJEeCwCHKuRJAB7lzrShDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T08:06:29.184812Z"},"content_sha256":"58048b226451aa4a06aae727f04dd80fedfa1029a61a497fa1d0ab2d91f485dd","schema_version":"1.0","event_id":"sha256:58048b226451aa4a06aae727f04dd80fedfa1029a61a497fa1d0ab2d91f485dd"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/TSQAJEL3CN5C7KPREQP7LW45SP/bundle.json","state_url":"https://pith.science/pith/TSQAJEL3CN5C7KPREQP7LW45SP/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/TSQAJEL3CN5C7KPREQP7LW45SP/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-13T08:06:29Z","links":{"resolver":"https://pith.science/pith/TSQAJEL3CN5C7KPREQP7LW45SP","bundle":"https://pith.science/pith/TSQAJEL3CN5C7KPREQP7LW45SP/bundle.json","state":"https://pith.science/pith/TSQAJEL3CN5C7KPREQP7LW45SP/state.json","well_known_bundle":"https://pith.science/.well-known/pith/TSQAJEL3CN5C7KPREQP7LW45SP/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:TSQAJEL3CN5C7KPREQP7LW45SP","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6f27f5cdb982b139f2a551e886a739bc0454e182a48a65fad9bf4578ae1452db","cross_cats_sorted":["quant-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-03-31T09:39:57Z","title_canon_sha256":"e14fc8d2d8c6e5066206c6ef382f15e38b89a6c47c673f07275322ed402a84ea"},"schema_version":"1.0","source":{"id":"2204.10182","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2204.10182","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"arxiv_version","alias_value":"2204.10182v1","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2204.10182","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"pith_short_12","alias_value":"TSQAJEL3CN5C","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"pith_short_16","alias_value":"TSQAJEL3CN5C7KPR","created_at":"2026-07-05T04:45:48Z"},{"alias_kind":"pith_short_8","alias_value":"TSQAJEL3","created_at":"2026-07-05T04:45:48Z"}],"graph_snapshots":[{"event_id":"sha256:58048b226451aa4a06aae727f04dd80fedfa1029a61a497fa1d0ab2d91f485dd","target":"graph","created_at":"2026-07-05T04:45:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2204.10182/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Temperature is one of the most relevant parameters for the regulation of intracellular processes. Measuring localized subcellular temperature gradients is fundamental for a deeper understanding of cell function, such as the genesis of action potentials, and cell metabolism. Here, we detect for the first time temperature variations (1{\\deg}C) associated with potentiation and depletion of neuronal firing, exploiting a nanoscale thermometer based on optically detected magnetic resonance in nanodiamonds. Our results provide a tool for assessing neuronal spiking activity under physiological and pat","authors_text":"A. Marcantoni, E. Bernardi, E. Moreva, F. Picollo, G. Petrini, G. Tomagra, I.P. Degiovanni, K. Kvakova, M. Genovese, P. Cigler, P. Traina, V. Carabelli","cross_cats":["quant-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-03-31T09:39:57Z","title":"Nanodiamond quantum sensors reveal temperature variation associated to hippocampal neurons firing"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2204.10182","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1f82f5b4b10d242bbddea9ab37438e646a93762563d061d1923f657da2f7adb6","target":"record","created_at":"2026-07-05T04:45:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6f27f5cdb982b139f2a551e886a739bc0454e182a48a65fad9bf4578ae1452db","cross_cats_sorted":["quant-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-03-31T09:39:57Z","title_canon_sha256":"e14fc8d2d8c6e5066206c6ef382f15e38b89a6c47c673f07275322ed402a84ea"},"schema_version":"1.0","source":{"id":"2204.10182","kind":"arxiv","version":1}},"canonical_sha256":"9ca004917b137a2fa9f1241ff5db9d93f3aa9bc528515fb5a9ee93cf8502bf29","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9ca004917b137a2fa9f1241ff5db9d93f3aa9bc528515fb5a9ee93cf8502bf29","first_computed_at":"2026-07-05T04:45:48.569241Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T04:45:48.569241Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"H26PZ1NNiDgG+a48KENc3pJ9H148MAmowCrbS0BHrhQql59UKiI+lF7GNzY+f1aAZwVO/ejCHzd0Niqy9h1uBQ==","signature_status":"signed_v1","signed_at":"2026-07-05T04:45:48.569729Z","signed_message":"canonical_sha256_bytes"},"source_id":"2204.10182","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1f82f5b4b10d242bbddea9ab37438e646a93762563d061d1923f657da2f7adb6","sha256:58048b226451aa4a06aae727f04dd80fedfa1029a61a497fa1d0ab2d91f485dd"],"state_sha256":"550e65cec2ffe76b1c5cc70e0800bed06c08b67480d385fce1e88daee03320db"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xBCv29CBscheuXWRIt9XF53yMySOQ36d/xAV+k+MellNzt4b8VSFordVTAozdvr7+7e+mPa7jghT9YoIGW9VAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-13T08:06:29.189871Z","bundle_sha256":"c70e26ba1c1566a15a0a6a826f2398630923a8bbcbc11d83c1062ae70f811fcd"}}