{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:TX2ZHJPVHXV7P4BAB75NZFD7Y4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c8944052e14b85215ca736822013bda2d724b643ffb31397769e82f1f950a962","cross_cats_sorted":["q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2016-10-04T20:39:06Z","title_canon_sha256":"89908b50605f59eee729111cad73dadccb864e4fc6a3ae75c2742057ee8444d1"},"schema_version":"1.0","source":{"id":"1610.01193","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1610.01193","created_at":"2026-05-18T00:39:40Z"},{"alias_kind":"arxiv_version","alias_value":"1610.01193v1","created_at":"2026-05-18T00:39:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1610.01193","created_at":"2026-05-18T00:39:40Z"},{"alias_kind":"pith_short_12","alias_value":"TX2ZHJPVHXV7","created_at":"2026-05-18T12:30:46Z"},{"alias_kind":"pith_short_16","alias_value":"TX2ZHJPVHXV7P4BA","created_at":"2026-05-18T12:30:46Z"},{"alias_kind":"pith_short_8","alias_value":"TX2ZHJPV","created_at":"2026-05-18T12:30:46Z"}],"graph_snapshots":[{"event_id":"sha256:ba72366b122b9d481873214a015651eab5f4184257f2959adf59675b17d02b96","target":"graph","created_at":"2026-05-18T00:39:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Although the disease-relevant microtubule-associated protein tau is known to severely inhibit kinesin-based transport in vitro, the potential mechanisms for reversing this detrimental effect to maintain healthy transport in cells remain unknown. Here we report the unambiguous upregulation of multiple-kinesin travel distance despite the presence of tau, via decreased single-kinesin velocity. Interestingly, the presence of tau also modestly reduced cargo velocity in multiple-kinesin transport, and our stochastic simulations indicate that the tau-mediated reduction in single-kinesin travel underl","authors_text":"Brian Nemec, Jing Xu, Maryse Lapierre-Landry, Stephen J. King","cross_cats":["q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2016-10-04T20:39:06Z","title":"Interplay between velocity and travel distance of kinesin-based transport in the presence of tau"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1610.01193","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:fc154f955b4c00b8696f1e3ef733d7c3213dd01640bc6cba3fb0d4fe2d5c74cc","target":"record","created_at":"2026-05-18T00:39:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c8944052e14b85215ca736822013bda2d724b643ffb31397769e82f1f950a962","cross_cats_sorted":["q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2016-10-04T20:39:06Z","title_canon_sha256":"89908b50605f59eee729111cad73dadccb864e4fc6a3ae75c2742057ee8444d1"},"schema_version":"1.0","source":{"id":"1610.01193","kind":"arxiv","version":1}},"canonical_sha256":"9df593a5f53debf7f0200ffadc947fc71c60c1c385e3f5cffe2430e75f4cca2b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"9df593a5f53debf7f0200ffadc947fc71c60c1c385e3f5cffe2430e75f4cca2b","first_computed_at":"2026-05-18T00:39:40.098268Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:39:40.098268Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"uRcHfHgDrN1NwVCEarxG4PM+S2toWKvgZa5py3QCoaq7dkEAy+XMxSzkn2QYuG9fpOk8wYog2QiRR3UAUvTgBw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:39:40.099030Z","signed_message":"canonical_sha256_bytes"},"source_id":"1610.01193","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:fc154f955b4c00b8696f1e3ef733d7c3213dd01640bc6cba3fb0d4fe2d5c74cc","sha256:ba72366b122b9d481873214a015651eab5f4184257f2959adf59675b17d02b96"],"state_sha256":"263f3bef5df7ad999329481236dd69116471104c4148d53bda8ab3227c21b774"}