{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2019:TZQSRZZWCQR6UEI3D5YTYDXY3O","short_pith_number":"pith:TZQSRZZW","schema_version":"1.0","canonical_sha256":"9e6128e7361423ea111b1f713c0ef8dba653c49bbe4d89537ecccaefb9db28da","source":{"kind":"arxiv","id":"1905.10662","version":1},"attestation_state":"computed","paper":{"title":"Optimal localization patterns in bacterial protein synthesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Jacky Nguyen, Michele Castellana","submitted_at":"2019-05-25T19:22:35Z","abstract_excerpt":"In $\\textit{Escherichia coli}$ bacterium, the molecular compounds involved in protein synthesis, messenger RNAs (mRNAs) and ribosomes, show marked intracellular localization patterns. Yet a quantitative understanding of the physical principles which would allow one to control protein synthesis by designing, bioengineering, and optimizing these localization patterns is still lacking. In this study, we consider a scenario where a synthetic modification of mRNA reaction-diffusion properties allows for controlling the localization and stoichiometry of mRNAs and polysomes$\\mathrm{-}$complexes of mu"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1905.10662","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-05-25T19:22:35Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.SC"],"title_canon_sha256":"9cf83ea50b4b10e8403468fab9dc5e344640558720e2bc2f51358cc74f7ce581","abstract_canon_sha256":"e96d19fe0ff6af1c734ad09f5d03b398b759d4bfebeef95501049b4b405509e8"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:45:05.655231Z","signature_b64":"PK4wyESqfFND/3LwivNx/1qStge8YWX2QZ5/tTYhJ53LofX6+OG78h73HKneclBBBUVIVUpNyAO9fa3s6xDfDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"9e6128e7361423ea111b1f713c0ef8dba653c49bbe4d89537ecccaefb9db28da","last_reissued_at":"2026-05-17T23:45:05.654453Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:45:05.654453Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Optimal localization patterns in bacterial protein synthesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Jacky Nguyen, Michele Castellana","submitted_at":"2019-05-25T19:22:35Z","abstract_excerpt":"In $\\textit{Escherichia coli}$ bacterium, the molecular compounds involved in protein synthesis, messenger RNAs (mRNAs) and ribosomes, show marked intracellular localization patterns. Yet a quantitative understanding of the physical principles which would allow one to control protein synthesis by designing, bioengineering, and optimizing these localization patterns is still lacking. In this study, we consider a scenario where a synthetic modification of mRNA reaction-diffusion properties allows for controlling the localization and stoichiometry of mRNAs and polysomes$\\mathrm{-}$complexes of mu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1905.10662","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1905.10662","created_at":"2026-05-17T23:45:05.654574+00:00"},{"alias_kind":"arxiv_version","alias_value":"1905.10662v1","created_at":"2026-05-17T23:45:05.654574+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1905.10662","created_at":"2026-05-17T23:45:05.654574+00:00"},{"alias_kind":"pith_short_12","alias_value":"TZQSRZZWCQR6","created_at":"2026-05-18T12:33:30.264802+00:00"},{"alias_kind":"pith_short_16","alias_value":"TZQSRZZWCQR6UEI3","created_at":"2026-05-18T12:33:30.264802+00:00"},{"alias_kind":"pith_short_8","alias_value":"TZQSRZZW","created_at":"2026-05-18T12:33:30.264802+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O","json":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O.json","graph_json":"https://pith.science/api/pith-number/TZQSRZZWCQR6UEI3D5YTYDXY3O/graph.json","events_json":"https://pith.science/api/pith-number/TZQSRZZWCQR6UEI3D5YTYDXY3O/events.json","paper":"https://pith.science/paper/TZQSRZZW"},"agent_actions":{"view_html":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O","download_json":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O.json","view_paper":"https://pith.science/paper/TZQSRZZW","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1905.10662&json=true","fetch_graph":"https://pith.science/api/pith-number/TZQSRZZWCQR6UEI3D5YTYDXY3O/graph.json","fetch_events":"https://pith.science/api/pith-number/TZQSRZZWCQR6UEI3D5YTYDXY3O/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O/action/timestamp_anchor","attest_storage":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O/action/storage_attestation","attest_author":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O/action/author_attestation","sign_citation":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O/action/citation_signature","submit_replication":"https://pith.science/pith/TZQSRZZWCQR6UEI3D5YTYDXY3O/action/replication_record"}},"created_at":"2026-05-17T23:45:05.654574+00:00","updated_at":"2026-05-17T23:45:05.654574+00:00"}