{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:U4FROTJEVXUAYDOV23GWI4K42E","short_pith_number":"pith:U4FROTJE","canonical_record":{"source":{"id":"2102.07713","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/publicdomain/zero/1.0/","primary_cat":"q-bio.GN","submitted_at":"2021-02-11T09:04:45Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"9eb62ea42bf96b4d948f56523db6da05debaf5c17022d18373e26c0ae7ea392d","abstract_canon_sha256":"55a634e410b38d70e0043f33a17473a4659fe405ae8b7ea08ed2788756a0175e"},"schema_version":"1.0"},"canonical_sha256":"a70b174d24ade80c0dd5d6cd64715cd122732ae18dc333dc9939dbf3a5304e3b","source":{"kind":"arxiv","id":"2102.07713","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2102.07713","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"arxiv_version","alias_value":"2102.07713v1","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2102.07713","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"pith_short_12","alias_value":"U4FROTJEVXUA","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"pith_short_16","alias_value":"U4FROTJEVXUAYDOV","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"pith_short_8","alias_value":"U4FROTJE","created_at":"2026-07-05T02:15:19Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:U4FROTJEVXUAYDOV23GWI4K42E","target":"record","payload":{"canonical_record":{"source":{"id":"2102.07713","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/publicdomain/zero/1.0/","primary_cat":"q-bio.GN","submitted_at":"2021-02-11T09:04:45Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"9eb62ea42bf96b4d948f56523db6da05debaf5c17022d18373e26c0ae7ea392d","abstract_canon_sha256":"55a634e410b38d70e0043f33a17473a4659fe405ae8b7ea08ed2788756a0175e"},"schema_version":"1.0"},"canonical_sha256":"a70b174d24ade80c0dd5d6cd64715cd122732ae18dc333dc9939dbf3a5304e3b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:15:19.225746Z","signature_b64":"fUKWvn9Tq8pnJzPd1I67aEc5ydFhK9ZP0DNZyIIuj9lBGA+aeI13B0Ms0Ji53gsim4YaHmCwoDOs4G8u0mMkBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a70b174d24ade80c0dd5d6cd64715cd122732ae18dc333dc9939dbf3a5304e3b","last_reissued_at":"2026-07-05T02:15:19.225283Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:15:19.225283Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2102.07713","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:15:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+osP19YgF0KNiAYu5kKsrLAZMCuMkPJemcYoG5MJWEny+KII9mS0HDWJqQQO0Wzf8vWrOFJ9v9gw4szqTs3DBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-20T06:24:58.828215Z"},"content_sha256":"720ec5282fb77f4b112c8b99866f1796b1050b8dfaba5bd64b239fce9ab94724","schema_version":"1.0","event_id":"sha256:720ec5282fb77f4b112c8b99866f1796b1050b8dfaba5bd64b239fce9ab94724"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:U4FROTJEVXUAYDOV23GWI4K42E","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Cancer Gene Profiling through Unsupervised Discovery","license":"http://creativecommons.org/publicdomain/zero/1.0/","headline":"","cross_cats":["cs.LG"],"primary_cat":"q-bio.GN","authors_text":"Alexandre Carr\\'e, Charlotte Robert, Emilie Alvarez Andres, Enzo Battistella, Eric Deutsch, Maria Vakalopoulou, Marvin Lerousseau, Nikos Paragios, Roger Sun, Sergey Nikolaev, St\\'ephane Niyoteka, Th\\'eo Estienne","submitted_at":"2021-02-11T09:04:45Z","abstract_excerpt":"Precision medicine is a paradigm shift in healthcare relying heavily on genomics data. However, the complexity of biological interactions, the large number of genes as well as the lack of comparisons on the analysis of data, remain a tremendous bottleneck regarding clinical adoption. In this paper, we introduce a novel, automatic and unsupervised framework to discover low-dimensional gene biomarkers. Our method is based on the LP-Stability algorithm, a high dimensional center-based unsupervised clustering algorithm, that offers modularity as concerns metric functions and scalability, while bei"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2102.07713","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2102.07713/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:15:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5CRNHhnPlP9WJRvo7TfYFTUSK2FoO770SVrE4L3wbO0zG90EYzYsjurHgHH/PU9JaV7CqGJl2sE0fFioqVs7CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-20T06:24:58.828608Z"},"content_sha256":"fb0edfb766f14eeeeefdc825b1c33a1dd5418a91e344d4a2de153b2aba6ae24d","schema_version":"1.0","event_id":"sha256:fb0edfb766f14eeeeefdc825b1c33a1dd5418a91e344d4a2de153b2aba6ae24d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/U4FROTJEVXUAYDOV23GWI4K42E/bundle.json","state_url":"https://pith.science/pith/U4FROTJEVXUAYDOV23GWI4K42E/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/U4FROTJEVXUAYDOV23GWI4K42E/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-20T06:24:58Z","links":{"resolver":"https://pith.science/pith/U4FROTJEVXUAYDOV23GWI4K42E","bundle":"https://pith.science/pith/U4FROTJEVXUAYDOV23GWI4K42E/bundle.json","state":"https://pith.science/pith/U4FROTJEVXUAYDOV23GWI4K42E/state.json","well_known_bundle":"https://pith.science/.well-known/pith/U4FROTJEVXUAYDOV23GWI4K42E/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:U4FROTJEVXUAYDOV23GWI4K42E","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"55a634e410b38d70e0043f33a17473a4659fe405ae8b7ea08ed2788756a0175e","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/publicdomain/zero/1.0/","primary_cat":"q-bio.GN","submitted_at":"2021-02-11T09:04:45Z","title_canon_sha256":"9eb62ea42bf96b4d948f56523db6da05debaf5c17022d18373e26c0ae7ea392d"},"schema_version":"1.0","source":{"id":"2102.07713","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2102.07713","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"arxiv_version","alias_value":"2102.07713v1","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2102.07713","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"pith_short_12","alias_value":"U4FROTJEVXUA","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"pith_short_16","alias_value":"U4FROTJEVXUAYDOV","created_at":"2026-07-05T02:15:19Z"},{"alias_kind":"pith_short_8","alias_value":"U4FROTJE","created_at":"2026-07-05T02:15:19Z"}],"graph_snapshots":[{"event_id":"sha256:fb0edfb766f14eeeeefdc825b1c33a1dd5418a91e344d4a2de153b2aba6ae24d","target":"graph","created_at":"2026-07-05T02:15:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2102.07713/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Precision medicine is a paradigm shift in healthcare relying heavily on genomics data. However, the complexity of biological interactions, the large number of genes as well as the lack of comparisons on the analysis of data, remain a tremendous bottleneck regarding clinical adoption. In this paper, we introduce a novel, automatic and unsupervised framework to discover low-dimensional gene biomarkers. Our method is based on the LP-Stability algorithm, a high dimensional center-based unsupervised clustering algorithm, that offers modularity as concerns metric functions and scalability, while bei","authors_text":"Alexandre Carr\\'e, Charlotte Robert, Emilie Alvarez Andres, Enzo Battistella, Eric Deutsch, Maria Vakalopoulou, Marvin Lerousseau, Nikos Paragios, Roger Sun, Sergey Nikolaev, St\\'ephane Niyoteka, Th\\'eo Estienne","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/publicdomain/zero/1.0/","primary_cat":"q-bio.GN","submitted_at":"2021-02-11T09:04:45Z","title":"Cancer Gene Profiling through Unsupervised Discovery"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2102.07713","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:720ec5282fb77f4b112c8b99866f1796b1050b8dfaba5bd64b239fce9ab94724","target":"record","created_at":"2026-07-05T02:15:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"55a634e410b38d70e0043f33a17473a4659fe405ae8b7ea08ed2788756a0175e","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/publicdomain/zero/1.0/","primary_cat":"q-bio.GN","submitted_at":"2021-02-11T09:04:45Z","title_canon_sha256":"9eb62ea42bf96b4d948f56523db6da05debaf5c17022d18373e26c0ae7ea392d"},"schema_version":"1.0","source":{"id":"2102.07713","kind":"arxiv","version":1}},"canonical_sha256":"a70b174d24ade80c0dd5d6cd64715cd122732ae18dc333dc9939dbf3a5304e3b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a70b174d24ade80c0dd5d6cd64715cd122732ae18dc333dc9939dbf3a5304e3b","first_computed_at":"2026-07-05T02:15:19.225283Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:15:19.225283Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"fUKWvn9Tq8pnJzPd1I67aEc5ydFhK9ZP0DNZyIIuj9lBGA+aeI13B0Ms0Ji53gsim4YaHmCwoDOs4G8u0mMkBA==","signature_status":"signed_v1","signed_at":"2026-07-05T02:15:19.225746Z","signed_message":"canonical_sha256_bytes"},"source_id":"2102.07713","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:720ec5282fb77f4b112c8b99866f1796b1050b8dfaba5bd64b239fce9ab94724","sha256:fb0edfb766f14eeeeefdc825b1c33a1dd5418a91e344d4a2de153b2aba6ae24d"],"state_sha256":"f33ca99fac11b43d5bbd96dd7b129d2156aa529d92ba9dc14c4496926550a90a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PufHRmyYEHlKQyMGKOmTNwjdCzQQLiFs4dD1Jv1yzIB6EKFXrfJd7efPfhKxPLp4cAvVHxCwGQiLYCTffKmHBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-20T06:24:58.830955Z","bundle_sha256":"cf1fa49b8ba256e8c8507f8d1ce25155baed89141d7f28c37e759ee2008ab171"}}