{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:U6DL7GE7QHXACUFD7OKOAAGOYG","short_pith_number":"pith:U6DL7GE7","canonical_record":{"source":{"id":"1606.02690","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-06-08T19:03:39Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"e7034ca0d9959317d9974085cc8c3af3a744fb9417257ad5ae46d136158ad239","abstract_canon_sha256":"6f6a5d4001d023660b9b6555dfc3b945935658f388c6d0f68bd64f523c04677e"},"schema_version":"1.0"},"canonical_sha256":"a786bf989f81ee0150a3fb94e000cec191718955eee356583a90aec6b6b1aecc","source":{"kind":"arxiv","id":"1606.02690","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1606.02690","created_at":"2026-05-18T01:12:40Z"},{"alias_kind":"arxiv_version","alias_value":"1606.02690v1","created_at":"2026-05-18T01:12:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1606.02690","created_at":"2026-05-18T01:12:40Z"},{"alias_kind":"pith_short_12","alias_value":"U6DL7GE7QHXA","created_at":"2026-05-18T12:30:46Z"},{"alias_kind":"pith_short_16","alias_value":"U6DL7GE7QHXACUFD","created_at":"2026-05-18T12:30:46Z"},{"alias_kind":"pith_short_8","alias_value":"U6DL7GE7","created_at":"2026-05-18T12:30:46Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:U6DL7GE7QHXACUFD7OKOAAGOYG","target":"record","payload":{"canonical_record":{"source":{"id":"1606.02690","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-06-08T19:03:39Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"e7034ca0d9959317d9974085cc8c3af3a744fb9417257ad5ae46d136158ad239","abstract_canon_sha256":"6f6a5d4001d023660b9b6555dfc3b945935658f388c6d0f68bd64f523c04677e"},"schema_version":"1.0"},"canonical_sha256":"a786bf989f81ee0150a3fb94e000cec191718955eee356583a90aec6b6b1aecc","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:12:40.847060Z","signature_b64":"Ri2wJ6OkMrqo9gahySkePvmuVtmdQv5vPrXvjeMEDXdwWCzMLUHA3cm+80RhvzQtbg+4OMZ85z8ZZpmLqb8hAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a786bf989f81ee0150a3fb94e000cec191718955eee356583a90aec6b6b1aecc","last_reissued_at":"2026-05-18T01:12:40.846710Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:12:40.846710Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1606.02690","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:12:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2T+CE0R+fsLak9U1VOQYwHgrAYpW8Pr1gfJZHGXpF9MNEmE5Rcmq3sjqrh1rSyxucWYwj2/kslblojWgkrv7CA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T21:19:38.351734Z"},"content_sha256":"982d4b8d48f802701df21cf71fcd2094851355965656b188e17d37fdf8a3dc89","schema_version":"1.0","event_id":"sha256:982d4b8d48f802701df21cf71fcd2094851355965656b188e17d37fdf8a3dc89"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:U6DL7GE7QHXACUFD7OKOAAGOYG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Integrative analysis of transcriptomic and metabolomic data via sparse canonical correlation analysis with incorporation of biological information","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"stat.ME","authors_text":"Qi Long, Sandra E. Safo, Shuzhao Li","submitted_at":"2016-06-08T19:03:39Z","abstract_excerpt":"Integrative analyses of different high dimensional data types are becoming increasingly popular. Similarly, incorporating prior functional relationships among variables in data analysis has been a topic of increasing interest as it helps elucidate underlying mechanisms among complex diseases. In this paper, the goal is to assess association between transcriptomic and metabolomic data from a Predictive Health Institute (PHI) study including healthy adults at high risk of developing cardiovascular diseases. To this end, we develop statistical methods for identifying sparse structure in canonical"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.02690","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:12:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+7oJ4y3Mu8+mzOY3YDNGa+bwtgwL6K13ZOUjaCWAyye0bA6fX1puSHR2vtvIwDTtae+q60nGnFMFkSm6F/ydCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T21:19:38.352467Z"},"content_sha256":"bb8d209f22f8aa4e7bdded97ff83c60872b7487dfd48dae3dc3c43252d957b28","schema_version":"1.0","event_id":"sha256:bb8d209f22f8aa4e7bdded97ff83c60872b7487dfd48dae3dc3c43252d957b28"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/U6DL7GE7QHXACUFD7OKOAAGOYG/bundle.json","state_url":"https://pith.science/pith/U6DL7GE7QHXACUFD7OKOAAGOYG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/U6DL7GE7QHXACUFD7OKOAAGOYG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-25T21:19:38Z","links":{"resolver":"https://pith.science/pith/U6DL7GE7QHXACUFD7OKOAAGOYG","bundle":"https://pith.science/pith/U6DL7GE7QHXACUFD7OKOAAGOYG/bundle.json","state":"https://pith.science/pith/U6DL7GE7QHXACUFD7OKOAAGOYG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/U6DL7GE7QHXACUFD7OKOAAGOYG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:U6DL7GE7QHXACUFD7OKOAAGOYG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6f6a5d4001d023660b9b6555dfc3b945935658f388c6d0f68bd64f523c04677e","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-06-08T19:03:39Z","title_canon_sha256":"e7034ca0d9959317d9974085cc8c3af3a744fb9417257ad5ae46d136158ad239"},"schema_version":"1.0","source":{"id":"1606.02690","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1606.02690","created_at":"2026-05-18T01:12:40Z"},{"alias_kind":"arxiv_version","alias_value":"1606.02690v1","created_at":"2026-05-18T01:12:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1606.02690","created_at":"2026-05-18T01:12:40Z"},{"alias_kind":"pith_short_12","alias_value":"U6DL7GE7QHXA","created_at":"2026-05-18T12:30:46Z"},{"alias_kind":"pith_short_16","alias_value":"U6DL7GE7QHXACUFD","created_at":"2026-05-18T12:30:46Z"},{"alias_kind":"pith_short_8","alias_value":"U6DL7GE7","created_at":"2026-05-18T12:30:46Z"}],"graph_snapshots":[{"event_id":"sha256:bb8d209f22f8aa4e7bdded97ff83c60872b7487dfd48dae3dc3c43252d957b28","target":"graph","created_at":"2026-05-18T01:12:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Integrative analyses of different high dimensional data types are becoming increasingly popular. Similarly, incorporating prior functional relationships among variables in data analysis has been a topic of increasing interest as it helps elucidate underlying mechanisms among complex diseases. In this paper, the goal is to assess association between transcriptomic and metabolomic data from a Predictive Health Institute (PHI) study including healthy adults at high risk of developing cardiovascular diseases. To this end, we develop statistical methods for identifying sparse structure in canonical","authors_text":"Qi Long, Sandra E. Safo, Shuzhao Li","cross_cats":["stat.AP"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-06-08T19:03:39Z","title":"Integrative analysis of transcriptomic and metabolomic data via sparse canonical correlation analysis with incorporation of biological information"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.02690","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:982d4b8d48f802701df21cf71fcd2094851355965656b188e17d37fdf8a3dc89","target":"record","created_at":"2026-05-18T01:12:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6f6a5d4001d023660b9b6555dfc3b945935658f388c6d0f68bd64f523c04677e","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-06-08T19:03:39Z","title_canon_sha256":"e7034ca0d9959317d9974085cc8c3af3a744fb9417257ad5ae46d136158ad239"},"schema_version":"1.0","source":{"id":"1606.02690","kind":"arxiv","version":1}},"canonical_sha256":"a786bf989f81ee0150a3fb94e000cec191718955eee356583a90aec6b6b1aecc","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a786bf989f81ee0150a3fb94e000cec191718955eee356583a90aec6b6b1aecc","first_computed_at":"2026-05-18T01:12:40.846710Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:12:40.846710Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Ri2wJ6OkMrqo9gahySkePvmuVtmdQv5vPrXvjeMEDXdwWCzMLUHA3cm+80RhvzQtbg+4OMZ85z8ZZpmLqb8hAg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:12:40.847060Z","signed_message":"canonical_sha256_bytes"},"source_id":"1606.02690","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:982d4b8d48f802701df21cf71fcd2094851355965656b188e17d37fdf8a3dc89","sha256:bb8d209f22f8aa4e7bdded97ff83c60872b7487dfd48dae3dc3c43252d957b28"],"state_sha256":"1165a874e99b3f1183700688bbc755dabb00ce8d4fff3192c5aa0dc9f69476e0"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pl1RqV7uT8+tE5vw4Nd6uL8yBrYNnQwGdUjfHjvISj6B71anggXXIp+XbgxAxxWyua4YAYnlt+CWh8vjDMSbDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-25T21:19:38.355989Z","bundle_sha256":"98c4c611e40440ea052da77976e7638c051fdcbe8e563ea16fb253ccd6091847"}}