{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:U7VDY7DTY6UZKNN2OANN54SUK4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d8fef1dfc513022fc9f6cd87d28288952db20edbfc155399ab6efe9486723acc","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-26T19:36:56Z","title_canon_sha256":"b4c45c6ef5428723a0a6ce69c28817ef5ffb7083221776c964749c517253c7d9"},"schema_version":"1.0","source":{"id":"1704.08315","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1704.08315","created_at":"2026-05-18T00:45:28Z"},{"alias_kind":"arxiv_version","alias_value":"1704.08315v1","created_at":"2026-05-18T00:45:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.08315","created_at":"2026-05-18T00:45:28Z"},{"alias_kind":"pith_short_12","alias_value":"U7VDY7DTY6UZ","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_16","alias_value":"U7VDY7DTY6UZKNN2","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_8","alias_value":"U7VDY7DT","created_at":"2026-05-18T12:31:46Z"}],"graph_snapshots":[{"event_id":"sha256:d881f5bafc49c4caac22eb4bf790b706ef9109aef897ae9d7bb84504b2821724","target":"graph","created_at":"2026-05-18T00:45:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Metal ions, including copper and zinc, have been implicated in the pathogenesis of Alzheimers disease through a variety of mechanisms including increased amyloid \\b{eta} affinity and redox effects. Recent reports have demonstrated that the amyloid \\b{eta} monomer does not necessarily travel through a definitive intermediary en-route to a stable amyloid fibril structure. Rather, amyloid \\b{eta} misfolding may follow a variety of pathways resulting in a fibrillar end-product or a variety of oligomeric end-products with a diversity of structures and sizes. The presence of metal ions has been demo","authors_text":"Francis Hane, Zoya Leonenko","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-26T19:36:56Z","title":"Effect of Metals on Kinetic Pathways of Amyloid-\\b{eta} Aggregation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.08315","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d92997ae6ac17288527031c907e3047ea0c249da25f047c17b6fc6a849975a50","target":"record","created_at":"2026-05-18T00:45:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d8fef1dfc513022fc9f6cd87d28288952db20edbfc155399ab6efe9486723acc","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-26T19:36:56Z","title_canon_sha256":"b4c45c6ef5428723a0a6ce69c28817ef5ffb7083221776c964749c517253c7d9"},"schema_version":"1.0","source":{"id":"1704.08315","kind":"arxiv","version":1}},"canonical_sha256":"a7ea3c7c73c7a99535ba701adef2545705b2356546bf4c63be719d807974a36a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a7ea3c7c73c7a99535ba701adef2545705b2356546bf4c63be719d807974a36a","first_computed_at":"2026-05-18T00:45:28.003488Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:45:28.003488Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"qOINgRSfen7i42Oybv7dIxGLxlaO6RcxwsvCAU6UEL2PtQaJr1Drf9wntpg7mR4pgBhC6suvjxgtonvQfDSSDA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:45:28.003947Z","signed_message":"canonical_sha256_bytes"},"source_id":"1704.08315","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d92997ae6ac17288527031c907e3047ea0c249da25f047c17b6fc6a849975a50","sha256:d881f5bafc49c4caac22eb4bf790b706ef9109aef897ae9d7bb84504b2821724"],"state_sha256":"aaf291cabf0867fcbfa822ce8bb11966dcd329871c3dba18425b6e7418436b38"}