{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:UBHQXKHSQMMI3HWTQODL5KEVAS","short_pith_number":"pith:UBHQXKHS","canonical_record":{"source":{"id":"2508.04742","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-08-06T04:25:40Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"d4e4552ccb64fed5350455244828094f3d0c7fc07a507d2bd38ecfdffa3e9030","abstract_canon_sha256":"a026ca3639766005e0c1714b19d5f1649d058792533211fcb575c901abec1420"},"schema_version":"1.0"},"canonical_sha256":"a04f0ba8f283188d9ed38386bea89504bbb7e3e9f7dfbd9e7c8d18819767f5ea","source":{"kind":"arxiv","id":"2508.04742","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.04742","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"arxiv_version","alias_value":"2508.04742v1","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.04742","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"pith_short_12","alias_value":"UBHQXKHSQMMI","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"pith_short_16","alias_value":"UBHQXKHSQMMI3HWT","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"pith_short_8","alias_value":"UBHQXKHS","created_at":"2026-07-05T11:50:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:UBHQXKHSQMMI3HWTQODL5KEVAS","target":"record","payload":{"canonical_record":{"source":{"id":"2508.04742","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-08-06T04:25:40Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"d4e4552ccb64fed5350455244828094f3d0c7fc07a507d2bd38ecfdffa3e9030","abstract_canon_sha256":"a026ca3639766005e0c1714b19d5f1649d058792533211fcb575c901abec1420"},"schema_version":"1.0"},"canonical_sha256":"a04f0ba8f283188d9ed38386bea89504bbb7e3e9f7dfbd9e7c8d18819767f5ea","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:50:00.975581Z","signature_b64":"9zPRo3PiASXoeJ5eVgFnIHSu5NS76P1zb8p4JIubKyh/Al/PTys+wPWjqA/A8WeP7xoHl7a+wBpQCU354mVLCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a04f0ba8f283188d9ed38386bea89504bbb7e3e9f7dfbd9e7c8d18819767f5ea","last_reissued_at":"2026-07-05T11:50:00.975116Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:50:00.975116Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2508.04742","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:50:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OfbonBAsh4sgdp7wv/CCvBIvgVTIVj+nVFV0yBFHpMkMp+Zja+YcQWB63SR1LGDWSaNmsgDjMsVH8htYQC3+CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T10:37:02.580535Z"},"content_sha256":"e82ecdcba1069f2287c56b886d5ab3a19c134216a5b2e6efa818fd9e74997e4a","schema_version":"1.0","event_id":"sha256:e82ecdcba1069f2287c56b886d5ab3a19c134216a5b2e6efa818fd9e74997e4a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:UBHQXKHSQMMI3HWTQODL5KEVAS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Discovery of Disease Relationships via Transcriptomic Signature Analysis Powered by Agentic AI","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG"],"primary_cat":"q-bio.GN","authors_text":"Haohan Wang, Ke Chen","submitted_at":"2025-08-06T04:25:40Z","abstract_excerpt":"Modern disease classification often overlooks molecular commonalities hidden beneath divergent clinical presentations. This study introduces a transcriptomics-driven framework for discovering disease relationships by analyzing over 1300 disease-condition pairs using GenoMAS, a fully automated agentic AI system. Beyond identifying robust gene-level overlaps, we develop a novel pathway-based similarity framework that integrates multi-database enrichment analysis to quantify functional convergence across diseases. The resulting disease similarity network reveals both known comorbidities and previ"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.04742","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2508.04742/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:50:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6H8RIQpnyLAGfpyEnSJvFAKjfJA3lJT/V4Ah188T3pHn00opv8a9prAEg9HTb9gjLTaIbxVpwOM1hpfK65IhCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T10:37:02.581085Z"},"content_sha256":"0e4401ca4036e95d375deac74a1c7651eeb975a2b352fda44c34205db6929445","schema_version":"1.0","event_id":"sha256:0e4401ca4036e95d375deac74a1c7651eeb975a2b352fda44c34205db6929445"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UBHQXKHSQMMI3HWTQODL5KEVAS/bundle.json","state_url":"https://pith.science/pith/UBHQXKHSQMMI3HWTQODL5KEVAS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UBHQXKHSQMMI3HWTQODL5KEVAS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-07T10:37:02Z","links":{"resolver":"https://pith.science/pith/UBHQXKHSQMMI3HWTQODL5KEVAS","bundle":"https://pith.science/pith/UBHQXKHSQMMI3HWTQODL5KEVAS/bundle.json","state":"https://pith.science/pith/UBHQXKHSQMMI3HWTQODL5KEVAS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UBHQXKHSQMMI3HWTQODL5KEVAS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:UBHQXKHSQMMI3HWTQODL5KEVAS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a026ca3639766005e0c1714b19d5f1649d058792533211fcb575c901abec1420","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-08-06T04:25:40Z","title_canon_sha256":"d4e4552ccb64fed5350455244828094f3d0c7fc07a507d2bd38ecfdffa3e9030"},"schema_version":"1.0","source":{"id":"2508.04742","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.04742","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"arxiv_version","alias_value":"2508.04742v1","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.04742","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"pith_short_12","alias_value":"UBHQXKHSQMMI","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"pith_short_16","alias_value":"UBHQXKHSQMMI3HWT","created_at":"2026-07-05T11:50:00Z"},{"alias_kind":"pith_short_8","alias_value":"UBHQXKHS","created_at":"2026-07-05T11:50:00Z"}],"graph_snapshots":[{"event_id":"sha256:0e4401ca4036e95d375deac74a1c7651eeb975a2b352fda44c34205db6929445","target":"graph","created_at":"2026-07-05T11:50:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.04742/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Modern disease classification often overlooks molecular commonalities hidden beneath divergent clinical presentations. This study introduces a transcriptomics-driven framework for discovering disease relationships by analyzing over 1300 disease-condition pairs using GenoMAS, a fully automated agentic AI system. Beyond identifying robust gene-level overlaps, we develop a novel pathway-based similarity framework that integrates multi-database enrichment analysis to quantify functional convergence across diseases. The resulting disease similarity network reveals both known comorbidities and previ","authors_text":"Haohan Wang, Ke Chen","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-08-06T04:25:40Z","title":"Discovery of Disease Relationships via Transcriptomic Signature Analysis Powered by Agentic AI"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.04742","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e82ecdcba1069f2287c56b886d5ab3a19c134216a5b2e6efa818fd9e74997e4a","target":"record","created_at":"2026-07-05T11:50:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a026ca3639766005e0c1714b19d5f1649d058792533211fcb575c901abec1420","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-08-06T04:25:40Z","title_canon_sha256":"d4e4552ccb64fed5350455244828094f3d0c7fc07a507d2bd38ecfdffa3e9030"},"schema_version":"1.0","source":{"id":"2508.04742","kind":"arxiv","version":1}},"canonical_sha256":"a04f0ba8f283188d9ed38386bea89504bbb7e3e9f7dfbd9e7c8d18819767f5ea","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a04f0ba8f283188d9ed38386bea89504bbb7e3e9f7dfbd9e7c8d18819767f5ea","first_computed_at":"2026-07-05T11:50:00.975116Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:50:00.975116Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"9zPRo3PiASXoeJ5eVgFnIHSu5NS76P1zb8p4JIubKyh/Al/PTys+wPWjqA/A8WeP7xoHl7a+wBpQCU354mVLCg==","signature_status":"signed_v1","signed_at":"2026-07-05T11:50:00.975581Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.04742","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e82ecdcba1069f2287c56b886d5ab3a19c134216a5b2e6efa818fd9e74997e4a","sha256:0e4401ca4036e95d375deac74a1c7651eeb975a2b352fda44c34205db6929445"],"state_sha256":"cf3acb044ec8070db484c0c706e28915d5edbbe722e8df24c713ca5d7d9ca290"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"E+P3LliomRbt1QBW+vMLBtuVfQBcBKrrM+aExGR+lVWVtCWFBa7SZ76slGo7HK6OqN1W258wMThT+Pfj94KfCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-07T10:37:02.584950Z","bundle_sha256":"d7fd929fd1630d9d6c51cbef0481d8a588ba07a10e904f73e5c8ee6a349c9f82"}}