{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:UBRQPHAQD72ZHNPJUBRB6DJLQM","short_pith_number":"pith:UBRQPHAQ","canonical_record":{"source":{"id":"2506.20957","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-26T02:45:38Z","cross_cats_sorted":["cs.AI"],"title_canon_sha256":"8312af27d894f516df89766c8d324e6fda46c56ed1e7a3882c561ded3b0c3d79","abstract_canon_sha256":"51360199e17988bcebb58b21528cfc627b4a597ba8b59aa3ed92b602fa9fad04"},"schema_version":"1.0"},"canonical_sha256":"a063079c101ff593b5e9a0621f0d2b831f1c51bf2b6756b2bcd2ab5f6da8d246","source":{"kind":"arxiv","id":"2506.20957","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.20957","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"arxiv_version","alias_value":"2506.20957v1","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.20957","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"pith_short_12","alias_value":"UBRQPHAQD72Z","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"pith_short_16","alias_value":"UBRQPHAQD72ZHNPJ","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"pith_short_8","alias_value":"UBRQPHAQ","created_at":"2026-07-05T11:27:36Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:UBRQPHAQD72ZHNPJUBRB6DJLQM","target":"record","payload":{"canonical_record":{"source":{"id":"2506.20957","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-26T02:45:38Z","cross_cats_sorted":["cs.AI"],"title_canon_sha256":"8312af27d894f516df89766c8d324e6fda46c56ed1e7a3882c561ded3b0c3d79","abstract_canon_sha256":"51360199e17988bcebb58b21528cfc627b4a597ba8b59aa3ed92b602fa9fad04"},"schema_version":"1.0"},"canonical_sha256":"a063079c101ff593b5e9a0621f0d2b831f1c51bf2b6756b2bcd2ab5f6da8d246","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:27:36.805826Z","signature_b64":"nse9zrZg8Qtn8VqpOxsMWNVuvgEd1K8ppWwMu/ZbPN3zjqzImVnUIB0edl8VsryRgbx0AIx1/udO3APAsXUnAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a063079c101ff593b5e9a0621f0d2b831f1c51bf2b6756b2bcd2ab5f6da8d246","last_reissued_at":"2026-07-05T11:27:36.805356Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:27:36.805356Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2506.20957","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:27:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Rcws/IqJ4RDjEK3W4TURRISPV2AOviOQGAL9wh5s+vQrhme4Vb9Nbnl/m59kbz5VTdHJBGMrUL7NQFqrxLj9Dg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T11:53:18.169354Z"},"content_sha256":"d5f300d44346efda7598b291b958654a734f0d1a7df136df6635a84d07ec6f3d","schema_version":"1.0","event_id":"sha256:d5f300d44346efda7598b291b958654a734f0d1a7df136df6635a84d07ec6f3d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:UBRQPHAQD72ZHNPJUBRB6DJLQM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Antibody Design and Optimization with Multi-scale Equivariant Graph Diffusion Models for Accurate Complex Antigen Binding","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.AI"],"primary_cat":"cs.LG","authors_text":"Jiameng Chen, Jia Wu, Wenbin Hu, Xiantao Cai","submitted_at":"2025-06-26T02:45:38Z","abstract_excerpt":"Antibody design remains a critical challenge in therapeutic and diagnostic development, particularly for complex antigens with diverse binding interfaces. Current computational methods face two main limitations: (1) capturing geometric features while preserving symmetries, and (2) generalizing novel antigen interfaces. Despite recent advancements, these methods often fail to accurately capture molecular interactions and maintain structural integrity. To address these challenges, we propose \\textbf{AbMEGD}, an end-to-end framework integrating \\textbf{M}ulti-scale \\textbf{E}quivariant \\textbf{G}"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.20957","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.20957/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:27:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8GESj46XHYsMMTx3BrGkGjL7SqVBKOiBdd5wuM+2M+Qy6jsPY1zTuAnMCg8Gu44EYz2Q00OVGTJ9Q8NWg/fTAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T11:53:18.169866Z"},"content_sha256":"ba1d5e6f8e2ab64649d68765a1c7de2deeed821c4102d3b246cf7fd81408f451","schema_version":"1.0","event_id":"sha256:ba1d5e6f8e2ab64649d68765a1c7de2deeed821c4102d3b246cf7fd81408f451"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UBRQPHAQD72ZHNPJUBRB6DJLQM/bundle.json","state_url":"https://pith.science/pith/UBRQPHAQD72ZHNPJUBRB6DJLQM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UBRQPHAQD72ZHNPJUBRB6DJLQM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-08T11:53:18Z","links":{"resolver":"https://pith.science/pith/UBRQPHAQD72ZHNPJUBRB6DJLQM","bundle":"https://pith.science/pith/UBRQPHAQD72ZHNPJUBRB6DJLQM/bundle.json","state":"https://pith.science/pith/UBRQPHAQD72ZHNPJUBRB6DJLQM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UBRQPHAQD72ZHNPJUBRB6DJLQM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:UBRQPHAQD72ZHNPJUBRB6DJLQM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"51360199e17988bcebb58b21528cfc627b4a597ba8b59aa3ed92b602fa9fad04","cross_cats_sorted":["cs.AI"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-26T02:45:38Z","title_canon_sha256":"8312af27d894f516df89766c8d324e6fda46c56ed1e7a3882c561ded3b0c3d79"},"schema_version":"1.0","source":{"id":"2506.20957","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.20957","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"arxiv_version","alias_value":"2506.20957v1","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.20957","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"pith_short_12","alias_value":"UBRQPHAQD72Z","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"pith_short_16","alias_value":"UBRQPHAQD72ZHNPJ","created_at":"2026-07-05T11:27:36Z"},{"alias_kind":"pith_short_8","alias_value":"UBRQPHAQ","created_at":"2026-07-05T11:27:36Z"}],"graph_snapshots":[{"event_id":"sha256:ba1d5e6f8e2ab64649d68765a1c7de2deeed821c4102d3b246cf7fd81408f451","target":"graph","created_at":"2026-07-05T11:27:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.20957/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Antibody design remains a critical challenge in therapeutic and diagnostic development, particularly for complex antigens with diverse binding interfaces. Current computational methods face two main limitations: (1) capturing geometric features while preserving symmetries, and (2) generalizing novel antigen interfaces. Despite recent advancements, these methods often fail to accurately capture molecular interactions and maintain structural integrity. To address these challenges, we propose \\textbf{AbMEGD}, an end-to-end framework integrating \\textbf{M}ulti-scale \\textbf{E}quivariant \\textbf{G}","authors_text":"Jiameng Chen, Jia Wu, Wenbin Hu, Xiantao Cai","cross_cats":["cs.AI"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-26T02:45:38Z","title":"Antibody Design and Optimization with Multi-scale Equivariant Graph Diffusion Models for Accurate Complex Antigen Binding"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.20957","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d5f300d44346efda7598b291b958654a734f0d1a7df136df6635a84d07ec6f3d","target":"record","created_at":"2026-07-05T11:27:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"51360199e17988bcebb58b21528cfc627b4a597ba8b59aa3ed92b602fa9fad04","cross_cats_sorted":["cs.AI"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-26T02:45:38Z","title_canon_sha256":"8312af27d894f516df89766c8d324e6fda46c56ed1e7a3882c561ded3b0c3d79"},"schema_version":"1.0","source":{"id":"2506.20957","kind":"arxiv","version":1}},"canonical_sha256":"a063079c101ff593b5e9a0621f0d2b831f1c51bf2b6756b2bcd2ab5f6da8d246","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a063079c101ff593b5e9a0621f0d2b831f1c51bf2b6756b2bcd2ab5f6da8d246","first_computed_at":"2026-07-05T11:27:36.805356Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:27:36.805356Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nse9zrZg8Qtn8VqpOxsMWNVuvgEd1K8ppWwMu/ZbPN3zjqzImVnUIB0edl8VsryRgbx0AIx1/udO3APAsXUnAw==","signature_status":"signed_v1","signed_at":"2026-07-05T11:27:36.805826Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.20957","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d5f300d44346efda7598b291b958654a734f0d1a7df136df6635a84d07ec6f3d","sha256:ba1d5e6f8e2ab64649d68765a1c7de2deeed821c4102d3b246cf7fd81408f451"],"state_sha256":"6d39177a521a880f8d69cd13b7c82c43a15b182bec898fa2238eb92dced925a3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kGy3FSIEs/V7HuR1GttDBmtMQ7zDeo0kfvTwr7bUHkRlc1C6bFS7ueYuGaVr/Ajn1iceSncEu13UwDej8ZLzDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-08T11:53:18.174141Z","bundle_sha256":"4513491f9c4558f88ec1ee42d21d2e3fed2f30cd75c121b21b6b31c51fc13ce5"}}