{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:UCFZ4CRD53TEGZL53CH3X55XSR","short_pith_number":"pith:UCFZ4CRD","canonical_record":{"source":{"id":"1902.07037","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-02-19T13:10:17Z","cross_cats_sorted":[],"title_canon_sha256":"9876666829297461c20696ca89b7dc2e58df1ac95ca020b13d5faa92e3da0957","abstract_canon_sha256":"c7e0178a71b240cb3a35942fda6dbfe1632440a9c99f6c845fab06710c15ddc2"},"schema_version":"1.0"},"canonical_sha256":"a08b9e0a23eee643657dd88fbbf7b7946fd7bd409e2de92e81ccfc5319d4e3e3","source":{"kind":"arxiv","id":"1902.07037","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1902.07037","created_at":"2026-05-17T23:53:40Z"},{"alias_kind":"arxiv_version","alias_value":"1902.07037v1","created_at":"2026-05-17T23:53:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1902.07037","created_at":"2026-05-17T23:53:40Z"},{"alias_kind":"pith_short_12","alias_value":"UCFZ4CRD53TE","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_16","alias_value":"UCFZ4CRD53TEGZL5","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_8","alias_value":"UCFZ4CRD","created_at":"2026-05-18T12:33:30Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:UCFZ4CRD53TEGZL53CH3X55XSR","target":"record","payload":{"canonical_record":{"source":{"id":"1902.07037","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-02-19T13:10:17Z","cross_cats_sorted":[],"title_canon_sha256":"9876666829297461c20696ca89b7dc2e58df1ac95ca020b13d5faa92e3da0957","abstract_canon_sha256":"c7e0178a71b240cb3a35942fda6dbfe1632440a9c99f6c845fab06710c15ddc2"},"schema_version":"1.0"},"canonical_sha256":"a08b9e0a23eee643657dd88fbbf7b7946fd7bd409e2de92e81ccfc5319d4e3e3","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:53:40.075349Z","signature_b64":"EQ/Z1S2JVMpBCTNHfokeS5VUsotKxKydB2u40/+A9XwAuv/H4IB2kmc/8sszljVZfapkR/CEWNy1YP+wii2mCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a08b9e0a23eee643657dd88fbbf7b7946fd7bd409e2de92e81ccfc5319d4e3e3","last_reissued_at":"2026-05-17T23:53:40.074869Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:53:40.074869Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1902.07037","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:53:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PD9Vp2FbS0ShqaFnxsus2i6TMgRTqyiFklb/6+Qn0M4nafo373eUkelahSUqJOOrLr0DW8W1uvQyVnBpHHhbDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T16:59:37.531729Z"},"content_sha256":"a9b81d623e203c550d154f0aa0fdb22ed71470520dfb87d80ee207acf5d17df6","schema_version":"1.0","event_id":"sha256:a9b81d623e203c550d154f0aa0fdb22ed71470520dfb87d80ee207acf5d17df6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:UCFZ4CRD53TEGZL53CH3X55XSR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Employing latent variable models to improve efficiency in composite endpoint analysis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Anna Berglind, James M.S. Wason, Jessica K. Barrett, Martina McMenamin","submitted_at":"2019-02-19T13:10:17Z","abstract_excerpt":"Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in each of the outcomes to be classed as a responder overall. One instance of this occurs in systemic lupus erythematosus (SLE), where the responder endpoint combines two continuous, one ordinal and one binary measure. The overall binary responder endpoint is typically analysed using logistic regression, resulting in a substantial loss of information. We propose a latent var"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1902.07037","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:53:40Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0YNg52UPCM9re3mSvhOIYLfsuNjsyYgLT3cD5GMDYIvafrpF1kINz75fOl6ZPhkxFhQrTXrZD0txK2fwP7p3Dg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T16:59:37.532280Z"},"content_sha256":"596be4273e8929306e27e78f62949e7c633788c3b6f79a2732fc2cdbcc42ceb2","schema_version":"1.0","event_id":"sha256:596be4273e8929306e27e78f62949e7c633788c3b6f79a2732fc2cdbcc42ceb2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UCFZ4CRD53TEGZL53CH3X55XSR/bundle.json","state_url":"https://pith.science/pith/UCFZ4CRD53TEGZL53CH3X55XSR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UCFZ4CRD53TEGZL53CH3X55XSR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-26T16:59:37Z","links":{"resolver":"https://pith.science/pith/UCFZ4CRD53TEGZL53CH3X55XSR","bundle":"https://pith.science/pith/UCFZ4CRD53TEGZL53CH3X55XSR/bundle.json","state":"https://pith.science/pith/UCFZ4CRD53TEGZL53CH3X55XSR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UCFZ4CRD53TEGZL53CH3X55XSR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:UCFZ4CRD53TEGZL53CH3X55XSR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c7e0178a71b240cb3a35942fda6dbfe1632440a9c99f6c845fab06710c15ddc2","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-02-19T13:10:17Z","title_canon_sha256":"9876666829297461c20696ca89b7dc2e58df1ac95ca020b13d5faa92e3da0957"},"schema_version":"1.0","source":{"id":"1902.07037","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1902.07037","created_at":"2026-05-17T23:53:40Z"},{"alias_kind":"arxiv_version","alias_value":"1902.07037v1","created_at":"2026-05-17T23:53:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1902.07037","created_at":"2026-05-17T23:53:40Z"},{"alias_kind":"pith_short_12","alias_value":"UCFZ4CRD53TE","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_16","alias_value":"UCFZ4CRD53TEGZL5","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_8","alias_value":"UCFZ4CRD","created_at":"2026-05-18T12:33:30Z"}],"graph_snapshots":[{"event_id":"sha256:596be4273e8929306e27e78f62949e7c633788c3b6f79a2732fc2cdbcc42ceb2","target":"graph","created_at":"2026-05-17T23:53:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in each of the outcomes to be classed as a responder overall. One instance of this occurs in systemic lupus erythematosus (SLE), where the responder endpoint combines two continuous, one ordinal and one binary measure. The overall binary responder endpoint is typically analysed using logistic regression, resulting in a substantial loss of information. We propose a latent var","authors_text":"Anna Berglind, James M.S. Wason, Jessica K. Barrett, Martina McMenamin","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-02-19T13:10:17Z","title":"Employing latent variable models to improve efficiency in composite endpoint analysis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1902.07037","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a9b81d623e203c550d154f0aa0fdb22ed71470520dfb87d80ee207acf5d17df6","target":"record","created_at":"2026-05-17T23:53:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c7e0178a71b240cb3a35942fda6dbfe1632440a9c99f6c845fab06710c15ddc2","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-02-19T13:10:17Z","title_canon_sha256":"9876666829297461c20696ca89b7dc2e58df1ac95ca020b13d5faa92e3da0957"},"schema_version":"1.0","source":{"id":"1902.07037","kind":"arxiv","version":1}},"canonical_sha256":"a08b9e0a23eee643657dd88fbbf7b7946fd7bd409e2de92e81ccfc5319d4e3e3","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a08b9e0a23eee643657dd88fbbf7b7946fd7bd409e2de92e81ccfc5319d4e3e3","first_computed_at":"2026-05-17T23:53:40.074869Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:53:40.074869Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"EQ/Z1S2JVMpBCTNHfokeS5VUsotKxKydB2u40/+A9XwAuv/H4IB2kmc/8sszljVZfapkR/CEWNy1YP+wii2mCQ==","signature_status":"signed_v1","signed_at":"2026-05-17T23:53:40.075349Z","signed_message":"canonical_sha256_bytes"},"source_id":"1902.07037","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a9b81d623e203c550d154f0aa0fdb22ed71470520dfb87d80ee207acf5d17df6","sha256:596be4273e8929306e27e78f62949e7c633788c3b6f79a2732fc2cdbcc42ceb2"],"state_sha256":"c7f5db724694bfe17611613f3fdf4b51e1751453e19eefda032f6b4f8a918aec"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"deL/FDaSixy9HAFRXTRQcSatXBEGr8L+Zyz6VycsKOsBERQyR/+roeUm3s5C2u3VoHa/KjDgyVP26zEoigtBCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-26T16:59:37.535265Z","bundle_sha256":"83899332813a838cee5f0ca5673f094041e68d9dd8432367455a71d4ca83641b"}}