{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:UELPE6GR7BRWPUCAN4Q7FQC3HQ","short_pith_number":"pith:UELPE6GR","canonical_record":{"source":{"id":"1708.00272","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-08-01T12:14:05Z","cross_cats_sorted":[],"title_canon_sha256":"609fd240d2823ac19e559577da91faaae68680580ed16f93231b243b80d1551e","abstract_canon_sha256":"e16abecde9c9754cabf3dbabc22f225fd45f635c2e4a2b375a39e2411fa8d3db"},"schema_version":"1.0"},"canonical_sha256":"a116f278d1f86367d0406f21f2c05b3c0c0eb13b01fee545dbd3f64be588ea47","source":{"kind":"arxiv","id":"1708.00272","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1708.00272","created_at":"2026-05-18T00:39:05Z"},{"alias_kind":"arxiv_version","alias_value":"1708.00272v1","created_at":"2026-05-18T00:39:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1708.00272","created_at":"2026-05-18T00:39:05Z"},{"alias_kind":"pith_short_12","alias_value":"UELPE6GR7BRW","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_16","alias_value":"UELPE6GR7BRWPUCA","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_8","alias_value":"UELPE6GR","created_at":"2026-05-18T12:31:46Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:UELPE6GR7BRWPUCAN4Q7FQC3HQ","target":"record","payload":{"canonical_record":{"source":{"id":"1708.00272","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-08-01T12:14:05Z","cross_cats_sorted":[],"title_canon_sha256":"609fd240d2823ac19e559577da91faaae68680580ed16f93231b243b80d1551e","abstract_canon_sha256":"e16abecde9c9754cabf3dbabc22f225fd45f635c2e4a2b375a39e2411fa8d3db"},"schema_version":"1.0"},"canonical_sha256":"a116f278d1f86367d0406f21f2c05b3c0c0eb13b01fee545dbd3f64be588ea47","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:39:05.627907Z","signature_b64":"x7zVnaA+BVNA6wENXhNF8Lo3Ri74597qcbZG7PXDwoXN7pnmOD3xIeb9OPquVRzw0ZRzBXmwjIvh87IIi1rtCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a116f278d1f86367d0406f21f2c05b3c0c0eb13b01fee545dbd3f64be588ea47","last_reissued_at":"2026-05-18T00:39:05.627343Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:39:05.627343Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1708.00272","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:39:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Z7FlIRhvsXUb5cAVOAmWwPpATxXW9O6Ag0T+X/QDCV32bPqSf18SGhc/P1xqwQhUHhTWT0Dx3jMq8V9Alyt5DA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T16:03:17.399254Z"},"content_sha256":"64fd503897c0d4bc398a10aa1c0258bac361cbae50d70e7a2487a36be2823731","schema_version":"1.0","event_id":"sha256:64fd503897c0d4bc398a10aa1c0258bac361cbae50d70e7a2487a36be2823731"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:UELPE6GR7BRWPUCAN4Q7FQC3HQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Angela Wood, Jessica M. B. Rees, Stephen Burgess","submitted_at":"2017-08-01T12:14:05Z","abstract_excerpt":"Methods have been developed for Mendelian randomization that can obtain consistent causal estimates while relaxing the instrumental variable assumptions. These include multivariable Mendelian randomization, in which a genetic variant may be associated with multiple risk factors so long as any association with the outcome is via the measured risk factors (measured pleiotropy), and the MR-Egger (Mendelian randomization-Egger) method, in which a genetic variant may be directly associated with the outcome not via the risk factor of interest, so long as the direct effects of the variants on the out"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1708.00272","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:39:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+2F2e/MjlT0b8O9Bc4m1urCf/Q8LBNP+r9iq2VsrWfqxMuG8FnIYAdD6/nwP6z1fzQOEhjWV7i6QXwBN8Y4mCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T16:03:17.399914Z"},"content_sha256":"571e2afe674211fbd75c50195d636db0fca8d093345a97867f42f1c6e7d5a704","schema_version":"1.0","event_id":"sha256:571e2afe674211fbd75c50195d636db0fca8d093345a97867f42f1c6e7d5a704"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UELPE6GR7BRWPUCAN4Q7FQC3HQ/bundle.json","state_url":"https://pith.science/pith/UELPE6GR7BRWPUCAN4Q7FQC3HQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UELPE6GR7BRWPUCAN4Q7FQC3HQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-28T16:03:17Z","links":{"resolver":"https://pith.science/pith/UELPE6GR7BRWPUCAN4Q7FQC3HQ","bundle":"https://pith.science/pith/UELPE6GR7BRWPUCAN4Q7FQC3HQ/bundle.json","state":"https://pith.science/pith/UELPE6GR7BRWPUCAN4Q7FQC3HQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UELPE6GR7BRWPUCAN4Q7FQC3HQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:UELPE6GR7BRWPUCAN4Q7FQC3HQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e16abecde9c9754cabf3dbabc22f225fd45f635c2e4a2b375a39e2411fa8d3db","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-08-01T12:14:05Z","title_canon_sha256":"609fd240d2823ac19e559577da91faaae68680580ed16f93231b243b80d1551e"},"schema_version":"1.0","source":{"id":"1708.00272","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1708.00272","created_at":"2026-05-18T00:39:05Z"},{"alias_kind":"arxiv_version","alias_value":"1708.00272v1","created_at":"2026-05-18T00:39:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1708.00272","created_at":"2026-05-18T00:39:05Z"},{"alias_kind":"pith_short_12","alias_value":"UELPE6GR7BRW","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_16","alias_value":"UELPE6GR7BRWPUCA","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_8","alias_value":"UELPE6GR","created_at":"2026-05-18T12:31:46Z"}],"graph_snapshots":[{"event_id":"sha256:571e2afe674211fbd75c50195d636db0fca8d093345a97867f42f1c6e7d5a704","target":"graph","created_at":"2026-05-18T00:39:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Methods have been developed for Mendelian randomization that can obtain consistent causal estimates while relaxing the instrumental variable assumptions. These include multivariable Mendelian randomization, in which a genetic variant may be associated with multiple risk factors so long as any association with the outcome is via the measured risk factors (measured pleiotropy), and the MR-Egger (Mendelian randomization-Egger) method, in which a genetic variant may be directly associated with the outcome not via the risk factor of interest, so long as the direct effects of the variants on the out","authors_text":"Angela Wood, Jessica M. B. Rees, Stephen Burgess","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-08-01T12:14:05Z","title":"Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1708.00272","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:64fd503897c0d4bc398a10aa1c0258bac361cbae50d70e7a2487a36be2823731","target":"record","created_at":"2026-05-18T00:39:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e16abecde9c9754cabf3dbabc22f225fd45f635c2e4a2b375a39e2411fa8d3db","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-08-01T12:14:05Z","title_canon_sha256":"609fd240d2823ac19e559577da91faaae68680580ed16f93231b243b80d1551e"},"schema_version":"1.0","source":{"id":"1708.00272","kind":"arxiv","version":1}},"canonical_sha256":"a116f278d1f86367d0406f21f2c05b3c0c0eb13b01fee545dbd3f64be588ea47","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a116f278d1f86367d0406f21f2c05b3c0c0eb13b01fee545dbd3f64be588ea47","first_computed_at":"2026-05-18T00:39:05.627343Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:39:05.627343Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"x7zVnaA+BVNA6wENXhNF8Lo3Ri74597qcbZG7PXDwoXN7pnmOD3xIeb9OPquVRzw0ZRzBXmwjIvh87IIi1rtCw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:39:05.627907Z","signed_message":"canonical_sha256_bytes"},"source_id":"1708.00272","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:64fd503897c0d4bc398a10aa1c0258bac361cbae50d70e7a2487a36be2823731","sha256:571e2afe674211fbd75c50195d636db0fca8d093345a97867f42f1c6e7d5a704"],"state_sha256":"3f2595ba09d440b17b10c9c65ad071b6b704d3279ec90ecdc00b37b937485c7b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kzMXv7USsEGK4HgTSiIPfEOsTBu4ZzwHP84lePyVoXFSZo5WA985diQEYpjFZPRJZlEM5UU2R1RL+NEvojeIBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-28T16:03:17.402816Z","bundle_sha256":"471bdd6749de925280f777feec1d72ec261820ddd05271be01206d4cc19189c6"}}