{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:UEWYXR3SFWJBJQMHXY5LPRINFZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d65093e39ad45d6e59e1bb054935f2f965b077f414a17c4ef2ed11095ca209e9","cross_cats_sorted":["cond-mat.mtrl-sci","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-02-13T00:19:35Z","title_canon_sha256":"7e9d60583edcbf907e952e04e993af301c258ca636de757d30dd6a49f39fe0c6"},"schema_version":"1.0","source":{"id":"1302.2958","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1302.2958","created_at":"2026-05-18T03:33:49Z"},{"alias_kind":"arxiv_version","alias_value":"1302.2958v1","created_at":"2026-05-18T03:33:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1302.2958","created_at":"2026-05-18T03:33:49Z"},{"alias_kind":"pith_short_12","alias_value":"UEWYXR3SFWJB","created_at":"2026-05-18T12:28:02Z"},{"alias_kind":"pith_short_16","alias_value":"UEWYXR3SFWJBJQMH","created_at":"2026-05-18T12:28:02Z"},{"alias_kind":"pith_short_8","alias_value":"UEWYXR3S","created_at":"2026-05-18T12:28:02Z"}],"graph_snapshots":[{"event_id":"sha256:23cdcd0502766eceed2b282d3b5ec7187d2a20c1727a134b9567e325ae4e3a5d","target":"graph","created_at":"2026-05-18T03:33:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We developed a novel detection method for osteopontin (OPN), a new biomarker for prostate cancer, by attaching a genetically engineered single chain variable fragment (scFv) protein with high binding affinity for OPN to a carbon nanotube field-effect transistor (NTFET). Chemical functionalization using diazonium salts is used to covalently attach scFv to NT-FETs, as confirmed by atomic force microscopy, while preserving the activity of the biological binding site for OPN. Electron transport measurements indicate that functionalized NT-FET may be used to detect the binding of OPN to the complem","authors_text":"A.T. Charlie Johnson, Brett R. Goldsmith, Jennifer Dailey, Jimson DSouza, Matthew K. Robinson, Mitchell B. Lerner, Tatiana Pazina","cross_cats":["cond-mat.mtrl-sci","q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-02-13T00:19:35Z","title":"Hybrids of a Genetically Engineered Antibody and a Carbon Nanotube Transistor for Detection of Prostate Cancer Biomarkers"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1302.2958","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e62d64be4198ac7fb5af0cd3dfea4760c2ec97a5de1e9a83506aff3a6bce25de","target":"record","created_at":"2026-05-18T03:33:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d65093e39ad45d6e59e1bb054935f2f965b077f414a17c4ef2ed11095ca209e9","cross_cats_sorted":["cond-mat.mtrl-sci","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-02-13T00:19:35Z","title_canon_sha256":"7e9d60583edcbf907e952e04e993af301c258ca636de757d30dd6a49f39fe0c6"},"schema_version":"1.0","source":{"id":"1302.2958","kind":"arxiv","version":1}},"canonical_sha256":"a12d8bc7722d9214c187be3ab7c50d2e421f875ca1794709bfda10ceadfda95b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a12d8bc7722d9214c187be3ab7c50d2e421f875ca1794709bfda10ceadfda95b","first_computed_at":"2026-05-18T03:33:49.223998Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:33:49.223998Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"TpU5GNfBLR8xFSQH3DesuHJ8DxurHQCZWJZdoH2N6+wjyqV6xGzEYv3HkbVtS8Nu+zE0VB3ReVZYpUuTWQ7rAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:33:49.224695Z","signed_message":"canonical_sha256_bytes"},"source_id":"1302.2958","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e62d64be4198ac7fb5af0cd3dfea4760c2ec97a5de1e9a83506aff3a6bce25de","sha256:23cdcd0502766eceed2b282d3b5ec7187d2a20c1727a134b9567e325ae4e3a5d"],"state_sha256":"42ad0f0403d6135fcce1c6bce1621b5605a0b1cbbc689e57caac160092b4b27e"}