{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:UFCDTZLIVIIDU227DMX76HXI2D","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"48a16e987f07ba68a4406b0b3ab627346e71eda886fe269e79895851cea7bcb1","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2014-08-12T15:31:56Z","title_canon_sha256":"6052ac81ed048bf257fd29ff1c0d827554675f6a7d68147c5dd2392b5c252729"},"schema_version":"1.0","source":{"id":"1408.2746","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1408.2746","created_at":"2026-05-18T02:45:22Z"},{"alias_kind":"arxiv_version","alias_value":"1408.2746v1","created_at":"2026-05-18T02:45:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.2746","created_at":"2026-05-18T02:45:22Z"},{"alias_kind":"pith_short_12","alias_value":"UFCDTZLIVIID","created_at":"2026-05-18T12:28:52Z"},{"alias_kind":"pith_short_16","alias_value":"UFCDTZLIVIIDU227","created_at":"2026-05-18T12:28:52Z"},{"alias_kind":"pith_short_8","alias_value":"UFCDTZLI","created_at":"2026-05-18T12:28:52Z"}],"graph_snapshots":[{"event_id":"sha256:b2e115b30e0eacea6a33654ae361234712e20df562fa2d500be65b51a85c5c1f","target":"graph","created_at":"2026-05-18T02:45:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Current inverse treatment planning methods that optimize both catheter positions and dwell times in prostate HDR brachytherapy use surrogate linear or quadratic objective functions that have no direct interpretation in terms of dose-volume histogram (DVH) criteria, do not result in an optimum or have long solution times.\n  We decrease the solution time of existing linear and quadratic dose-based programming models (LP and QP, respectively) to allow optimizing over potential catheter positions using mixed integer programming. An additional average speed-up of 75% can be obtained by stopping the","authors_text":"Aswin L. Hoffmann, Bram L. Gorissen, Dick den Hertog","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2014-08-12T15:31:56Z","title":"Mixed integer programming improves comprehensibility and plan quality in inverse optimization of prostate HDR-brachytherapy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.2746","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d91556720e158f4c1bd3edfe29191b57a7235cf60485cefaac791fea4587d194","target":"record","created_at":"2026-05-18T02:45:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"48a16e987f07ba68a4406b0b3ab627346e71eda886fe269e79895851cea7bcb1","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2014-08-12T15:31:56Z","title_canon_sha256":"6052ac81ed048bf257fd29ff1c0d827554675f6a7d68147c5dd2392b5c252729"},"schema_version":"1.0","source":{"id":"1408.2746","kind":"arxiv","version":1}},"canonical_sha256":"a14439e568aa103a6b5f1b2fff1ee8d0fdb2d21b03c155bc5b9bcef74f390a51","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a14439e568aa103a6b5f1b2fff1ee8d0fdb2d21b03c155bc5b9bcef74f390a51","first_computed_at":"2026-05-18T02:45:22.406163Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:45:22.406163Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"unEBxT3Wbughl0WZstB2UI5rAGv4g9+Rhm8iWvHHQ6tlZqrD0qr3ui2sqIEQ6MIMnJoSTxeTwYaAqVQ/yDMJCQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:45:22.406577Z","signed_message":"canonical_sha256_bytes"},"source_id":"1408.2746","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d91556720e158f4c1bd3edfe29191b57a7235cf60485cefaac791fea4587d194","sha256:b2e115b30e0eacea6a33654ae361234712e20df562fa2d500be65b51a85c5c1f"],"state_sha256":"c7e455e3f06450c7dcaf0ee2f80775df650bfbf57c9f004216073b71315eb12b"}