{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:UFDJCVBEE4LS3MVZ54LLMRECET","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0335a7f3572cd0eeb690dd7f28d83e4bab3012e1912794b25d8f9fa64e880af5","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-07-26T05:37:55Z","title_canon_sha256":"7585ce568e492094b82a596b816541b6a0cd3e7b55c311db9642c440c51e387f"},"schema_version":"1.0","source":{"id":"2507.19805","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2507.19805","created_at":"2026-07-05T11:43:42Z"},{"alias_kind":"arxiv_version","alias_value":"2507.19805v1","created_at":"2026-07-05T11:43:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2507.19805","created_at":"2026-07-05T11:43:42Z"},{"alias_kind":"pith_short_12","alias_value":"UFDJCVBEE4LS","created_at":"2026-07-05T11:43:42Z"},{"alias_kind":"pith_short_16","alias_value":"UFDJCVBEE4LS3MVZ","created_at":"2026-07-05T11:43:42Z"},{"alias_kind":"pith_short_8","alias_value":"UFDJCVBE","created_at":"2026-07-05T11:43:42Z"}],"graph_snapshots":[{"event_id":"sha256:631d821147fe153d6bf6dbd95f4138a663e45caf6c06dd01b00001b9fcea4fc1","target":"graph","created_at":"2026-07-05T11:43:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2507.19805/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Aberrant protein-protein interactions (PPIs) underpin a plethora of human diseases, and disruption of these harmful interactions constitute a compelling treatment avenue. Advances in computational approaches to PPI prediction have closely followed progress in deep learning and natural language processing. In this review, we outline the state-of the-art for sequence-based PPI prediction methods and explore their impact on target identification and drug discovery. We begin with an overview of commonly used training data sources and techniques used to curate these data to enhance the quality of t","authors_text":"Fran\\c{c}ois Charih, James R. Green, Kyle K. Biggar","cross_cats":["cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-07-26T05:37:55Z","title":"Sequence-based protein-protein interaction prediction and its applications in drug discovery"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2507.19805","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:34f303f6bfe6250bda0c497337f5cf01f7c5b5340de58ac24c7e87bcb2858282","target":"record","created_at":"2026-07-05T11:43:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0335a7f3572cd0eeb690dd7f28d83e4bab3012e1912794b25d8f9fa64e880af5","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-07-26T05:37:55Z","title_canon_sha256":"7585ce568e492094b82a596b816541b6a0cd3e7b55c311db9642c440c51e387f"},"schema_version":"1.0","source":{"id":"2507.19805","kind":"arxiv","version":1}},"canonical_sha256":"a14691542427172db2b9ef16b6448224fb274d6a92cc465dddcf9cacd32c2e1b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a14691542427172db2b9ef16b6448224fb274d6a92cc465dddcf9cacd32c2e1b","first_computed_at":"2026-07-05T11:43:42.373587Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:43:42.373587Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"2wqUWV8CfQJWwx5eL3rtmR/IMBS0q0GRFTlJkaZ3N/LMaQMv4aooRdI/VuICEY5WehVWfrkCvduFtn2TtYv+BQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:43:42.374009Z","signed_message":"canonical_sha256_bytes"},"source_id":"2507.19805","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:34f303f6bfe6250bda0c497337f5cf01f7c5b5340de58ac24c7e87bcb2858282","sha256:631d821147fe153d6bf6dbd95f4138a663e45caf6c06dd01b00001b9fcea4fc1"],"state_sha256":"f4e3b65cc4de67ed39d6e8c6ba73e5cc449435167ba87ac080550ff75fafc809"}