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Based on the new light curves, the refined transit ephemeris of XO-4b is $P = 4.1250828 \\pm 0.0000040$ days and $T_c [BJD_TDB] = 2454485.93323 \\pm 0.00039$. We measured the Rossiter-McLaughlin effect of XO-4b and estimated the sky-projected angle between the stellar spin axis and the planetary orbital axis to be $\\lambda = -46.7^{\\circ} ^{+8.1^{\\circ}}_{-6.1^{\\circ}}$. 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