{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:ULMI4RSSIW3CK6R4XIG3XHHMV7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"98caa99814fece6631b0c27b9cd7ff785ce8fa3d57e8ed5156dc693f642c2cb4","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2017-08-15T06:42:21Z","title_canon_sha256":"6d0bd407551becc8e0369fb3074682c7905e19f96f5c237425d5e0f7194fee5a"},"schema_version":"1.0","source":{"id":"1708.04414","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1708.04414","created_at":"2026-05-18T00:33:38Z"},{"alias_kind":"arxiv_version","alias_value":"1708.04414v1","created_at":"2026-05-18T00:33:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1708.04414","created_at":"2026-05-18T00:33:38Z"},{"alias_kind":"pith_short_12","alias_value":"ULMI4RSSIW3C","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_16","alias_value":"ULMI4RSSIW3CK6R4","created_at":"2026-05-18T12:31:46Z"},{"alias_kind":"pith_short_8","alias_value":"ULMI4RSS","created_at":"2026-05-18T12:31:46Z"}],"graph_snapshots":[{"event_id":"sha256:c3ce958a7cc3f05e1ee513e390710f31a560059edf7fb60b495bb153b9e78913","target":"graph","created_at":"2026-05-18T00:33:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Adhesion between a T cell and an antigen presenting cell is achieved by TCR-pMHC and LFA1-ICAM1 protein complexes. These segregate to form a special pattern, known as the immunological synapse (IS), consisting of a central quasi-circular domain of TCR-pMHC bonds surrounded by a peripheral domain of LFA1-ICAM1 complexes. Insights gained from imaging studies had led to the conclusion that the formation of the central adhesion domain in the IS is driven by active (ATP-driven) mechanisms. Recent studies, however, suggested that passive (thermodynamic) mechanisms may also play an important role in ","authors_text":"Nadiv Dharan, Oded Farago","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2017-08-15T06:42:21Z","title":"Interplay between membrane elasticity and active cytoskeleton forces regulates the aggregation dynamics of the immunological synapse"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1708.04414","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:699a90ad208d3a36ad0da9a0ebc4111c253c1c608ccc8029b25b48b0b73da9d6","target":"record","created_at":"2026-05-18T00:33:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"98caa99814fece6631b0c27b9cd7ff785ce8fa3d57e8ed5156dc693f642c2cb4","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2017-08-15T06:42:21Z","title_canon_sha256":"6d0bd407551becc8e0369fb3074682c7905e19f96f5c237425d5e0f7194fee5a"},"schema_version":"1.0","source":{"id":"1708.04414","kind":"arxiv","version":1}},"canonical_sha256":"a2d88e465245b6257a3cba0dbb9cecaffaa82c17c8e16f34568fde027c9b5d31","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a2d88e465245b6257a3cba0dbb9cecaffaa82c17c8e16f34568fde027c9b5d31","first_computed_at":"2026-05-18T00:33:38.929871Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:33:38.929871Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"HoUoT79FRpdZ+gK5deYVuBvT3nORmyE5wKsPkXrlA2Z52oUxNG2AfXRzOFeMGJKlU8AblY6AxzLbEWz4Kpv8CQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:33:38.930527Z","signed_message":"canonical_sha256_bytes"},"source_id":"1708.04414","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:699a90ad208d3a36ad0da9a0ebc4111c253c1c608ccc8029b25b48b0b73da9d6","sha256:c3ce958a7cc3f05e1ee513e390710f31a560059edf7fb60b495bb153b9e78913"],"state_sha256":"f6fbe48b5380c6df65e1aca0d3ad548b4571a6e2d214d22f24dbdfa438384365"}