{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:ULYG4ZPMAI7BWCJJ6AETXRXFNJ","short_pith_number":"pith:ULYG4ZPM","canonical_record":{"source":{"id":"2305.13395","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CL","submitted_at":"2023-05-22T18:15:57Z","cross_cats_sorted":[],"title_canon_sha256":"7cecfc4e8cc9acc788b6911eb3beff114539e3c3baf33b8f24897c8e01eb8038","abstract_canon_sha256":"79b7811d61771328a4e1473625a36528bb9a0c308c88f5df40a2eddcf123e259"},"schema_version":"1.0"},"canonical_sha256":"a2f06e65ec023e1b0929f0093bc6e56a795b178987852741a9b554e8d0c1d0b7","source":{"kind":"arxiv","id":"2305.13395","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2305.13395","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"arxiv_version","alias_value":"2305.13395v2","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2305.13395","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"pith_short_12","alias_value":"ULYG4ZPMAI7B","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"pith_short_16","alias_value":"ULYG4ZPMAI7BWCJJ","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"pith_short_8","alias_value":"ULYG4ZPM","created_at":"2026-07-05T07:03:10Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:ULYG4ZPMAI7BWCJJ6AETXRXFNJ","target":"record","payload":{"canonical_record":{"source":{"id":"2305.13395","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CL","submitted_at":"2023-05-22T18:15:57Z","cross_cats_sorted":[],"title_canon_sha256":"7cecfc4e8cc9acc788b6911eb3beff114539e3c3baf33b8f24897c8e01eb8038","abstract_canon_sha256":"79b7811d61771328a4e1473625a36528bb9a0c308c88f5df40a2eddcf123e259"},"schema_version":"1.0"},"canonical_sha256":"a2f06e65ec023e1b0929f0093bc6e56a795b178987852741a9b554e8d0c1d0b7","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:03:10.215668Z","signature_b64":"RS7DhaLoqAhXAUhbuFt5W5/5ahkDqrM7cT3J7rjCZHBFSOEpKMkGy8rFKAv3ukzeuarAuQddjglOQ/TicZsjDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a2f06e65ec023e1b0929f0093bc6e56a795b178987852741a9b554e8d0c1d0b7","last_reissued_at":"2026-07-05T07:03:10.215173Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:03:10.215173Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2305.13395","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:03:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"7Vf+CqRVCaRy50U2SOhp8oYNVAnnwvkCPPuBniQaTEt9B0y+x8/y1LgaTXj5WbUln8wh4Dlrejnff1UcOtu9BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T20:45:49.858465Z"},"content_sha256":"35f94cac011b9dcf52c8d5345f690fe54df5b798923ef0f81fdbe5abbe63c109","schema_version":"1.0","event_id":"sha256:35f94cac011b9dcf52c8d5345f690fe54df5b798923ef0f81fdbe5abbe63c109"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:ULYG4ZPMAI7BWCJJ6AETXRXFNJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"BioDEX: Large-Scale Biomedical Adverse Drug Event Extraction for Real-World Pharmacovigilance","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"cs.CL","authors_text":"Aneiss Ghodsi, Chris Develder, Christopher Potts, Fran\\c{c}ois Remy, Jack Collins, Johannes Deleu, Karel D'Oosterlinck, Klim Zaporojets, Simon Ellershaw, Thomas Demeester","submitted_at":"2023-05-22T18:15:57Z","abstract_excerpt":"Timely and accurate extraction of Adverse Drug Events (ADE) from biomedical literature is paramount for public safety, but involves slow and costly manual labor. We set out to improve drug safety monitoring (pharmacovigilance, PV) through the use of Natural Language Processing (NLP). We introduce BioDEX, a large-scale resource for Biomedical adverse Drug Event Extraction, rooted in the historical output of drug safety reporting in the U.S. BioDEX consists of 65k abstracts and 19k full-text biomedical papers with 256k associated document-level safety reports created by medical experts. The core"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2305.13395","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2305.13395/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:03:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"EHC4oaRIrSyvRv2WHkRvJn5gnOGyuvrVlrbS0GieBNYlvHOoGrs6crUi4R4q19dWgkfNrdXhpogHTYcNgmRBCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T20:45:49.859008Z"},"content_sha256":"0554c783fd8114d8e7334b4d385f7c1cd0c3981854c2594e7e278cd78d1a3b74","schema_version":"1.0","event_id":"sha256:0554c783fd8114d8e7334b4d385f7c1cd0c3981854c2594e7e278cd78d1a3b74"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ULYG4ZPMAI7BWCJJ6AETXRXFNJ/bundle.json","state_url":"https://pith.science/pith/ULYG4ZPMAI7BWCJJ6AETXRXFNJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ULYG4ZPMAI7BWCJJ6AETXRXFNJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-08T20:45:49Z","links":{"resolver":"https://pith.science/pith/ULYG4ZPMAI7BWCJJ6AETXRXFNJ","bundle":"https://pith.science/pith/ULYG4ZPMAI7BWCJJ6AETXRXFNJ/bundle.json","state":"https://pith.science/pith/ULYG4ZPMAI7BWCJJ6AETXRXFNJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ULYG4ZPMAI7BWCJJ6AETXRXFNJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:ULYG4ZPMAI7BWCJJ6AETXRXFNJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"79b7811d61771328a4e1473625a36528bb9a0c308c88f5df40a2eddcf123e259","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CL","submitted_at":"2023-05-22T18:15:57Z","title_canon_sha256":"7cecfc4e8cc9acc788b6911eb3beff114539e3c3baf33b8f24897c8e01eb8038"},"schema_version":"1.0","source":{"id":"2305.13395","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2305.13395","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"arxiv_version","alias_value":"2305.13395v2","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2305.13395","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"pith_short_12","alias_value":"ULYG4ZPMAI7B","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"pith_short_16","alias_value":"ULYG4ZPMAI7BWCJJ","created_at":"2026-07-05T07:03:10Z"},{"alias_kind":"pith_short_8","alias_value":"ULYG4ZPM","created_at":"2026-07-05T07:03:10Z"}],"graph_snapshots":[{"event_id":"sha256:0554c783fd8114d8e7334b4d385f7c1cd0c3981854c2594e7e278cd78d1a3b74","target":"graph","created_at":"2026-07-05T07:03:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2305.13395/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Timely and accurate extraction of Adverse Drug Events (ADE) from biomedical literature is paramount for public safety, but involves slow and costly manual labor. We set out to improve drug safety monitoring (pharmacovigilance, PV) through the use of Natural Language Processing (NLP). We introduce BioDEX, a large-scale resource for Biomedical adverse Drug Event Extraction, rooted in the historical output of drug safety reporting in the U.S. BioDEX consists of 65k abstracts and 19k full-text biomedical papers with 256k associated document-level safety reports created by medical experts. The core","authors_text":"Aneiss Ghodsi, Chris Develder, Christopher Potts, Fran\\c{c}ois Remy, Jack Collins, Johannes Deleu, Karel D'Oosterlinck, Klim Zaporojets, Simon Ellershaw, Thomas Demeester","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CL","submitted_at":"2023-05-22T18:15:57Z","title":"BioDEX: Large-Scale Biomedical Adverse Drug Event Extraction for Real-World Pharmacovigilance"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2305.13395","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:35f94cac011b9dcf52c8d5345f690fe54df5b798923ef0f81fdbe5abbe63c109","target":"record","created_at":"2026-07-05T07:03:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"79b7811d61771328a4e1473625a36528bb9a0c308c88f5df40a2eddcf123e259","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CL","submitted_at":"2023-05-22T18:15:57Z","title_canon_sha256":"7cecfc4e8cc9acc788b6911eb3beff114539e3c3baf33b8f24897c8e01eb8038"},"schema_version":"1.0","source":{"id":"2305.13395","kind":"arxiv","version":2}},"canonical_sha256":"a2f06e65ec023e1b0929f0093bc6e56a795b178987852741a9b554e8d0c1d0b7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a2f06e65ec023e1b0929f0093bc6e56a795b178987852741a9b554e8d0c1d0b7","first_computed_at":"2026-07-05T07:03:10.215173Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:03:10.215173Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"RS7DhaLoqAhXAUhbuFt5W5/5ahkDqrM7cT3J7rjCZHBFSOEpKMkGy8rFKAv3ukzeuarAuQddjglOQ/TicZsjDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T07:03:10.215668Z","signed_message":"canonical_sha256_bytes"},"source_id":"2305.13395","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:35f94cac011b9dcf52c8d5345f690fe54df5b798923ef0f81fdbe5abbe63c109","sha256:0554c783fd8114d8e7334b4d385f7c1cd0c3981854c2594e7e278cd78d1a3b74"],"state_sha256":"15d1d8bd9d77034720e3c674d838baaf909a9048547c33b587acb4bf5afa8b93"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZTzjw/HgdcVef7coofBydjY6wS2wG3YgBvUOq+edJh8gfuGXpzk4t4tBEY3t/Kh59M6gwqQZ550FCUzq8x6rAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-08T20:45:49.863067Z","bundle_sha256":"20ee2a5970956ca141965e6eab0e38c85ad00cd0d101df79f61b32651e1b1212"}}