{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:UMBIKTZKWT3LNOCJ36CDE6DDLG","short_pith_number":"pith:UMBIKTZK","canonical_record":{"source":{"id":"2407.21233","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-07-30T22:40:32Z","cross_cats_sorted":["cs.AI","cs.CV"],"title_canon_sha256":"c10584c0704901dca50e516faa9bed5ae3a7ef00a765ffa5394db9b91852631e","abstract_canon_sha256":"fbc8d4ce62785dd6afe2790c6e3199d007e3e6df126f9ac32adabd23e2ed2fc2"},"schema_version":"1.0"},"canonical_sha256":"a302854f2ab4f6b6b849df84327863599e18af40f31d20042ff543f313c4da25","source":{"kind":"arxiv","id":"2407.21233","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2407.21233","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"arxiv_version","alias_value":"2407.21233v1","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2407.21233","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"pith_short_12","alias_value":"UMBIKTZKWT3L","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"pith_short_16","alias_value":"UMBIKTZKWT3LNOCJ","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"pith_short_8","alias_value":"UMBIKTZK","created_at":"2026-07-05T08:50:36Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:UMBIKTZKWT3LNOCJ36CDE6DDLG","target":"record","payload":{"canonical_record":{"source":{"id":"2407.21233","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-07-30T22:40:32Z","cross_cats_sorted":["cs.AI","cs.CV"],"title_canon_sha256":"c10584c0704901dca50e516faa9bed5ae3a7ef00a765ffa5394db9b91852631e","abstract_canon_sha256":"fbc8d4ce62785dd6afe2790c6e3199d007e3e6df126f9ac32adabd23e2ed2fc2"},"schema_version":"1.0"},"canonical_sha256":"a302854f2ab4f6b6b849df84327863599e18af40f31d20042ff543f313c4da25","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:50:36.341652Z","signature_b64":"pdbCi+yLR3tRWapI5ytwAB5MaZIb/SDEEyRhF4YeApy7tZwdCqyOM28mesU/l3jr3FpKMxvIPzfGIr7VdmA2BQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a302854f2ab4f6b6b849df84327863599e18af40f31d20042ff543f313c4da25","last_reissued_at":"2026-07-05T08:50:36.341178Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:50:36.341178Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2407.21233","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:50:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Z0zMOv0oQHukcYl3Q8pKSLDYshXHMOsLaAdzaZJM/J2TLL/1u6lYhocvZDAuICUTnQtLUdSdTOOElVJBm83KDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-05T12:59:56.936325Z"},"content_sha256":"1eae290432a23a72098c2155f5a6d2c559b222bf5de5df305e661445e6196f70","schema_version":"1.0","event_id":"sha256:1eae290432a23a72098c2155f5a6d2c559b222bf5de5df305e661445e6196f70"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:UMBIKTZKWT3LNOCJ36CDE6DDLG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"TMA-Grid: An open-source, zero-footprint web application for FAIR Tissue MicroArray De-arraying","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.AI","cs.CV"],"primary_cat":"q-bio.TO","authors_text":"Aaron Ge, Jeya Balasubramanian, Jonas S. Almeida, Maire A. Duggan, Monjoy Saha, Montserrat Garc\\'ia-Closas, Mustapha Abubakar, Petra Lenz, Praphulla MS Bhawsar","submitted_at":"2024-07-30T22:40:32Z","abstract_excerpt":"Background:\n  Tissue Microarrays (TMAs) significantly increase analytical efficiency in histopathology and large-scale epidemiologic studies by allowing multiple tissue cores to be scanned on a single slide. The individual cores can be digitally extracted and then linked to metadata for analysis in a process known as de-arraying. However, TMAs often contain core misalignments and artifacts due to assembly errors, which can adversely affect the reliability of the extracted cores during the de-arraying process. Moreover, conventional approaches for TMA de-arraying rely on desktop solutions.There"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2407.21233","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2407.21233/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:50:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Qv9inrFSzWcvuTHQ7pAGCJ2/ede+mpojEQIIUkpl4pyOSMbEPN20GFo1lYjywGpmsVja35pi0EoVJTat2oLUDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-05T12:59:56.936847Z"},"content_sha256":"c846727cb96bd42aaffde7a75e7bcb48578a972d5bfe881892dcb0e2a6022f94","schema_version":"1.0","event_id":"sha256:c846727cb96bd42aaffde7a75e7bcb48578a972d5bfe881892dcb0e2a6022f94"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UMBIKTZKWT3LNOCJ36CDE6DDLG/bundle.json","state_url":"https://pith.science/pith/UMBIKTZKWT3LNOCJ36CDE6DDLG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UMBIKTZKWT3LNOCJ36CDE6DDLG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-05T12:59:56Z","links":{"resolver":"https://pith.science/pith/UMBIKTZKWT3LNOCJ36CDE6DDLG","bundle":"https://pith.science/pith/UMBIKTZKWT3LNOCJ36CDE6DDLG/bundle.json","state":"https://pith.science/pith/UMBIKTZKWT3LNOCJ36CDE6DDLG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UMBIKTZKWT3LNOCJ36CDE6DDLG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:UMBIKTZKWT3LNOCJ36CDE6DDLG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fbc8d4ce62785dd6afe2790c6e3199d007e3e6df126f9ac32adabd23e2ed2fc2","cross_cats_sorted":["cs.AI","cs.CV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-07-30T22:40:32Z","title_canon_sha256":"c10584c0704901dca50e516faa9bed5ae3a7ef00a765ffa5394db9b91852631e"},"schema_version":"1.0","source":{"id":"2407.21233","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2407.21233","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"arxiv_version","alias_value":"2407.21233v1","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2407.21233","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"pith_short_12","alias_value":"UMBIKTZKWT3L","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"pith_short_16","alias_value":"UMBIKTZKWT3LNOCJ","created_at":"2026-07-05T08:50:36Z"},{"alias_kind":"pith_short_8","alias_value":"UMBIKTZK","created_at":"2026-07-05T08:50:36Z"}],"graph_snapshots":[{"event_id":"sha256:c846727cb96bd42aaffde7a75e7bcb48578a972d5bfe881892dcb0e2a6022f94","target":"graph","created_at":"2026-07-05T08:50:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2407.21233/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Background:\n  Tissue Microarrays (TMAs) significantly increase analytical efficiency in histopathology and large-scale epidemiologic studies by allowing multiple tissue cores to be scanned on a single slide. The individual cores can be digitally extracted and then linked to metadata for analysis in a process known as de-arraying. However, TMAs often contain core misalignments and artifacts due to assembly errors, which can adversely affect the reliability of the extracted cores during the de-arraying process. Moreover, conventional approaches for TMA de-arraying rely on desktop solutions.There","authors_text":"Aaron Ge, Jeya Balasubramanian, Jonas S. Almeida, Maire A. Duggan, Monjoy Saha, Montserrat Garc\\'ia-Closas, Mustapha Abubakar, Petra Lenz, Praphulla MS Bhawsar","cross_cats":["cs.AI","cs.CV"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-07-30T22:40:32Z","title":"TMA-Grid: An open-source, zero-footprint web application for FAIR Tissue MicroArray De-arraying"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2407.21233","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1eae290432a23a72098c2155f5a6d2c559b222bf5de5df305e661445e6196f70","target":"record","created_at":"2026-07-05T08:50:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fbc8d4ce62785dd6afe2790c6e3199d007e3e6df126f9ac32adabd23e2ed2fc2","cross_cats_sorted":["cs.AI","cs.CV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-07-30T22:40:32Z","title_canon_sha256":"c10584c0704901dca50e516faa9bed5ae3a7ef00a765ffa5394db9b91852631e"},"schema_version":"1.0","source":{"id":"2407.21233","kind":"arxiv","version":1}},"canonical_sha256":"a302854f2ab4f6b6b849df84327863599e18af40f31d20042ff543f313c4da25","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a302854f2ab4f6b6b849df84327863599e18af40f31d20042ff543f313c4da25","first_computed_at":"2026-07-05T08:50:36.341178Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T08:50:36.341178Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"pdbCi+yLR3tRWapI5ytwAB5MaZIb/SDEEyRhF4YeApy7tZwdCqyOM28mesU/l3jr3FpKMxvIPzfGIr7VdmA2BQ==","signature_status":"signed_v1","signed_at":"2026-07-05T08:50:36.341652Z","signed_message":"canonical_sha256_bytes"},"source_id":"2407.21233","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1eae290432a23a72098c2155f5a6d2c559b222bf5de5df305e661445e6196f70","sha256:c846727cb96bd42aaffde7a75e7bcb48578a972d5bfe881892dcb0e2a6022f94"],"state_sha256":"cccf9f3022834313941b5341ad0593c8917b3e09d4d5271496373a18e60ba4d3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"UrBLouRSU32K8VfqXlp61Es+2os7iCmndwVVfM/A749WkMbuHnXA3P2pN5BznJzaTdCC1FOs8ULdIeOIL8bMAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-05T12:59:56.941279Z","bundle_sha256":"3750e33ba10b7914ea3434c7932a97282a50bac355e09d73b48758b0f45814da"}}