{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:UMZUBGK4BJ5SAKQTD6D775F75F","short_pith_number":"pith:UMZUBGK4","canonical_record":{"source":{"id":"2605.18118","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2026-05-18T09:26:38Z","cross_cats_sorted":[],"title_canon_sha256":"ca4d8b74dc7f83bcc4c683b5df0285acd3d76359784babef8fc9513c4277aefa","abstract_canon_sha256":"5b8f8ad8582c3ece45d40feee49f03ab6735f028988618611c2ab9e121896fe0"},"schema_version":"1.0"},"canonical_sha256":"a33340995c0a7b202a131f87fff4bfe97d4ead6a3dc4dc3601a4c59bf02d2f81","source":{"kind":"arxiv","id":"2605.18118","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2605.18118","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"arxiv_version","alias_value":"2605.18118v1","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2605.18118","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"pith_short_12","alias_value":"UMZUBGK4BJ5S","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"pith_short_16","alias_value":"UMZUBGK4BJ5SAKQT","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"pith_short_8","alias_value":"UMZUBGK4","created_at":"2026-05-20T00:05:16Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:UMZUBGK4BJ5SAKQTD6D775F75F","target":"record","payload":{"canonical_record":{"source":{"id":"2605.18118","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2026-05-18T09:26:38Z","cross_cats_sorted":[],"title_canon_sha256":"ca4d8b74dc7f83bcc4c683b5df0285acd3d76359784babef8fc9513c4277aefa","abstract_canon_sha256":"5b8f8ad8582c3ece45d40feee49f03ab6735f028988618611c2ab9e121896fe0"},"schema_version":"1.0"},"canonical_sha256":"a33340995c0a7b202a131f87fff4bfe97d4ead6a3dc4dc3601a4c59bf02d2f81","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-20T00:05:16.877516Z","signature_b64":"85osClLpV7mfaMIU5fmJTa0qpG9cgCap0vF6rd/mm+x2Ht7KATbE6rqjM5Keoqs/ygLz2346uvXj9MncnJeLBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a33340995c0a7b202a131f87fff4bfe97d4ead6a3dc4dc3601a4c59bf02d2f81","last_reissued_at":"2026-05-20T00:05:16.876820Z","signature_status":"signed_v1","first_computed_at":"2026-05-20T00:05:16.876820Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2605.18118","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-20T00:05:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9sGOfg6vqonQAnZv4tUrgpfOYDyOsH57FVZXCj5HFwGSng64yHerqg7JRrUcOyNufg4e39TS53GijlZNyWl+Bw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-21T19:15:16.283711Z"},"content_sha256":"afb482990ea268a474c7268f1a815aebf7c557b1f51fbb3edf2d18d8bfdae8a1","schema_version":"1.0","event_id":"sha256:afb482990ea268a474c7268f1a815aebf7c557b1f51fbb3edf2d18d8bfdae8a1"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:UMZUBGK4BJ5SAKQTD6D775F75F","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Functional Whole-Brain Models: A New Framework for Unifying Brain Structure and Cognitive Function","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Gorka Zamora-L\\'opez, Jan Fousek, Jorge F. Mejias, Leonardo Dalla Porta, Mario Senden","submitted_at":"2026-05-18T09:26:38Z","abstract_excerpt":"Contemporary computational neuroscience features two prominent modeling traditions. Bottom-up whole-brain modeling (WBM) builds biophysically detailed simulations of brain structure and dynamics, whereas top-down neuroconnectionism optimizes deep neural networks for functional performance. Each has achieved remarkable success yet remains incomplete with WBMs lacking functional competence and neuroconnectionist models showing limited biological grounding. Here we propose functional whole-brain models (fWBMs) as a unified modeling paradigm that integrates structural and dynamical realism with ta"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2605.18118","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2605.18118/integrity.json","findings":[],"available":true,"detectors_run":[{"name":"claim_evidence","ran_at":"2026-05-19T23:41:59.149454Z","status":"completed","version":"1.0.0","findings_count":0},{"name":"ai_meta_artifact","ran_at":"2026-05-19T23:33:35.405192Z","status":"skipped","version":"1.0.0","findings_count":0}],"snapshot_sha256":"9114af268ab39676fdf8afa482a5e93d5b112a1b5532c2a2e65a6009fe835219"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-20T00:05:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Q0wyeBLxRCinlKLdDULhtbkoZFQkCoDlk9e2mbJjIECQyZHzjmBIx7VpNlKmHgtNIgol6O9uS5TwrnUPnRb/BQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-21T19:15:16.284122Z"},"content_sha256":"da2799ee22d97e64d76752f48ceab4102d17746a253b26507e4befb49cc0c697","schema_version":"1.0","event_id":"sha256:da2799ee22d97e64d76752f48ceab4102d17746a253b26507e4befb49cc0c697"},{"event_type":"integrity_finding","subject_pith_number":"pith:2026:UMZUBGK4BJ5SAKQTD6D775F75F","target":"integrity","payload":{"note":"DOI in the printed bibliography is fragmented by whitespace or line breaks. A longer candidate (10.1038/s42003-021-02537-9|) was visible in the surrounding text but could not be confirmed against doi.org as printed.","snippet":"A. L´ opez-Gonz´ alez, R. Panda, A. Ponce-Alvarez, G. Zamora-L´ opez, A. Escrichs, C. Martial, A. Thibaut, O. Gosseries, M. Kringelbach, A. Annen, S. Laureys, and G. Deco. “Loss of con- sciousness reduces the stability of brain hubs and the","arxiv_id":"2605.18118","detector":"doi_compliance","evidence":{"ref_index":29,"verdict_class":"incontrovertible","resolved_title":null,"printed_excerpt":"A. L´ opez-Gonz´ alez, R. Panda, A. Ponce-Alvarez, G. Zamora-L´ opez, A. Escrichs, C. Martial, A. Thibaut, O. Gosseries, M. Kringelbach, A. Annen, S. Laureys, and G. Deco. “Loss of con- sciousness reduces the stability of brain hubs and the","reconstructed_doi":"10.1038/s42003-021-02537-9|"},"severity":"advisory","ref_index":29,"audited_at":"2026-05-20T00:44:13.670969Z","event_type":"pith.integrity.v1","detected_doi":"10.1038/s42003-021-02537-9|","detector_url":"https://pith.science/pith-integrity-protocol#doi_compliance","external_url":null,"finding_type":"recoverable_identifier","evidence_hash":"cbc783f2a1fddbad9d588ace29393e315f5a1ee1ddc1f438c0a26aad9cb59e91","paper_version":1,"verdict_class":"incontrovertible","resolved_title":null,"detector_version":"1.0.0","detected_arxiv_id":null,"integrity_event_id":3886,"payload_sha256":"3e14260cefb26953e1b5f6280a9016493993c61b89dcb1272bba42e3ee7307d5","signature_b64":"ow1wm4GzuEs/koQL1mWTmA8v9UlfiPW27JDf6AVjS1oXncbEtUzUpuEpqe4RoOYrkhQ2Njt9KJUdy8tSB/PKBA==","signing_key_id":"pith-v1-2026-05"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-20T00:47:29Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2cLjvhbS5hDAICFH9gsmybAtsccHxmu1t0/D9ctBmxyA7/urIT2Weqsr8R4cp8Y4Txibc3WEZ+JCIq34B32MCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-21T19:15:16.285310Z"},"content_sha256":"c8dcc9cf60afdbc3e5ee086e332a7f529429347bca1ad70fa8ad11542148ecd2","schema_version":"1.0","event_id":"sha256:c8dcc9cf60afdbc3e5ee086e332a7f529429347bca1ad70fa8ad11542148ecd2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UMZUBGK4BJ5SAKQTD6D775F75F/bundle.json","state_url":"https://pith.science/pith/UMZUBGK4BJ5SAKQTD6D775F75F/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UMZUBGK4BJ5SAKQTD6D775F75F/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-21T19:15:16Z","links":{"resolver":"https://pith.science/pith/UMZUBGK4BJ5SAKQTD6D775F75F","bundle":"https://pith.science/pith/UMZUBGK4BJ5SAKQTD6D775F75F/bundle.json","state":"https://pith.science/pith/UMZUBGK4BJ5SAKQTD6D775F75F/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UMZUBGK4BJ5SAKQTD6D775F75F/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:UMZUBGK4BJ5SAKQTD6D775F75F","merge_version":"pith-open-graph-merge-v1","event_count":3,"valid_event_count":3,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5b8f8ad8582c3ece45d40feee49f03ab6735f028988618611c2ab9e121896fe0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2026-05-18T09:26:38Z","title_canon_sha256":"ca4d8b74dc7f83bcc4c683b5df0285acd3d76359784babef8fc9513c4277aefa"},"schema_version":"1.0","source":{"id":"2605.18118","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2605.18118","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"arxiv_version","alias_value":"2605.18118v1","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2605.18118","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"pith_short_12","alias_value":"UMZUBGK4BJ5S","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"pith_short_16","alias_value":"UMZUBGK4BJ5SAKQT","created_at":"2026-05-20T00:05:16Z"},{"alias_kind":"pith_short_8","alias_value":"UMZUBGK4","created_at":"2026-05-20T00:05:16Z"}],"graph_snapshots":[{"event_id":"sha256:da2799ee22d97e64d76752f48ceab4102d17746a253b26507e4befb49cc0c697","target":"graph","created_at":"2026-05-20T00:05:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[{"findings_count":0,"name":"claim_evidence","ran_at":"2026-05-19T23:41:59.149454Z","status":"completed","version":"1.0.0"},{"findings_count":0,"name":"ai_meta_artifact","ran_at":"2026-05-19T23:33:35.405192Z","status":"skipped","version":"1.0.0"}],"endpoint":"/pith/2605.18118/integrity.json","findings":[],"snapshot_sha256":"9114af268ab39676fdf8afa482a5e93d5b112a1b5532c2a2e65a6009fe835219","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Contemporary computational neuroscience features two prominent modeling traditions. Bottom-up whole-brain modeling (WBM) builds biophysically detailed simulations of brain structure and dynamics, whereas top-down neuroconnectionism optimizes deep neural networks for functional performance. Each has achieved remarkable success yet remains incomplete with WBMs lacking functional competence and neuroconnectionist models showing limited biological grounding. Here we propose functional whole-brain models (fWBMs) as a unified modeling paradigm that integrates structural and dynamical realism with ta","authors_text":"Gorka Zamora-L\\'opez, Jan Fousek, Jorge F. Mejias, Leonardo Dalla Porta, Mario Senden","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2026-05-18T09:26:38Z","title":"Functional Whole-Brain Models: A New Framework for Unifying Brain Structure and Cognitive Function"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2605.18118","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:afb482990ea268a474c7268f1a815aebf7c557b1f51fbb3edf2d18d8bfdae8a1","target":"record","created_at":"2026-05-20T00:05:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5b8f8ad8582c3ece45d40feee49f03ab6735f028988618611c2ab9e121896fe0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.NC","submitted_at":"2026-05-18T09:26:38Z","title_canon_sha256":"ca4d8b74dc7f83bcc4c683b5df0285acd3d76359784babef8fc9513c4277aefa"},"schema_version":"1.0","source":{"id":"2605.18118","kind":"arxiv","version":1}},"canonical_sha256":"a33340995c0a7b202a131f87fff4bfe97d4ead6a3dc4dc3601a4c59bf02d2f81","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a33340995c0a7b202a131f87fff4bfe97d4ead6a3dc4dc3601a4c59bf02d2f81","first_computed_at":"2026-05-20T00:05:16.876820Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-20T00:05:16.876820Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"85osClLpV7mfaMIU5fmJTa0qpG9cgCap0vF6rd/mm+x2Ht7KATbE6rqjM5Keoqs/ygLz2346uvXj9MncnJeLBQ==","signature_status":"signed_v1","signed_at":"2026-05-20T00:05:16.877516Z","signed_message":"canonical_sha256_bytes"},"source_id":"2605.18118","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:afb482990ea268a474c7268f1a815aebf7c557b1f51fbb3edf2d18d8bfdae8a1","sha256:da2799ee22d97e64d76752f48ceab4102d17746a253b26507e4befb49cc0c697","sha256:c8dcc9cf60afdbc3e5ee086e332a7f529429347bca1ad70fa8ad11542148ecd2"],"state_sha256":"fe8daa5ce8e5ed66d4773ae31b7c9baac294d13fab1f367d0dfed7cf2f069d02"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+GuWnNSF426NodyfAWbW10n4rWufQGySDQqCH4Tv5fqPIDBzwbcS2FgwKVDdwfhrul7sA/7iQo26MhEzIJ+IDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-21T19:15:16.287625Z","bundle_sha256":"93644b3e8f45b5f4a6f6ae0cfd9f6c6891d425928d4eabebb52b9350f9e92401"}}