{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:UPQFUAXEQ3MHBEBGNCP2WHTD2F","short_pith_number":"pith:UPQFUAXE","canonical_record":{"source":{"id":"2112.07780","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-14T23:03:00Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"0b2c1fb157913359cbc3ea6ea1e374cf376863c0d3e81fcf69a453f4e8548713","abstract_canon_sha256":"f72e44a8714fd6346049406c01a25b399743d49bdd5f613143ee2ec83d21be63"},"schema_version":"1.0"},"canonical_sha256":"a3e05a02e486d8709026689fab1e63d17561a77dde779fe09c0675786447cd61","source":{"kind":"arxiv","id":"2112.07780","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2112.07780","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"arxiv_version","alias_value":"2112.07780v1","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2112.07780","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"pith_short_12","alias_value":"UPQFUAXEQ3MH","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"pith_short_16","alias_value":"UPQFUAXEQ3MHBEBG","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"pith_short_8","alias_value":"UPQFUAXE","created_at":"2026-07-05T03:41:06Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:UPQFUAXEQ3MHBEBGNCP2WHTD2F","target":"record","payload":{"canonical_record":{"source":{"id":"2112.07780","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-14T23:03:00Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"0b2c1fb157913359cbc3ea6ea1e374cf376863c0d3e81fcf69a453f4e8548713","abstract_canon_sha256":"f72e44a8714fd6346049406c01a25b399743d49bdd5f613143ee2ec83d21be63"},"schema_version":"1.0"},"canonical_sha256":"a3e05a02e486d8709026689fab1e63d17561a77dde779fe09c0675786447cd61","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:41:06.416495Z","signature_b64":"MYV4q62GtPbRmw5+K/PVuK7yI/raniyiyub7pnUDrZ219hYdaXU4HhyXE0O0WUFFLaP3WSa0COTidKYpY0nZCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a3e05a02e486d8709026689fab1e63d17561a77dde779fe09c0675786447cd61","last_reissued_at":"2026-07-05T03:41:06.416086Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:41:06.416086Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2112.07780","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:41:06Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DJZXHpjIhiXFIKdQowKviQR04CczvaHFBTuRgvHOxkUdHoUuRKTsK+55cEAUvl7LaxyASnQMHFYgho7j1itHBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-09T04:33:00.426590Z"},"content_sha256":"f98829b635e9b03ea2ac203fc321cc0412fd449e185c6accdc83950dbf0c9d59","schema_version":"1.0","event_id":"sha256:f98829b635e9b03ea2ac203fc321cc0412fd449e185c6accdc83950dbf0c9d59"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:UPQFUAXEQ3MHBEBGNCP2WHTD2F","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Quantitative optical coherence tomography reveals rod photoreceptor degeneration in early diabetic retinopathy","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.QM","authors_text":"David Le, Jennifer I. Lim, Taeyoon Son, Xincheng Yao","submitted_at":"2021-12-14T23:03:00Z","abstract_excerpt":"Purpose: This study is to test the feasibility of optical coherence tomography (OCT) detection of photoreceptor abnormality and to verify the photoreceptor abnormality is rod predominated in early DR . Methods: OCT images were acquired from normal eyes, diabetic eyes with no diabetic retinopathy (NoDR) and mild DR. Quantitative features, including length features quantifying band distances and reflectance intensity features among the external limiting membrane (ELM), inner segment ellipsoid (ISe), interdigitation zone (IZ) and retinal pigment epithelium (RPE) were determined. Comparative OCT a"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2112.07780","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2112.07780/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:41:06Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"n4QKtM0Iki1Sd3hvUI6a3dutRlZUGvvI8l6VauGWf6wUU4j8kibD3FZeLeS7t0qtQ3FeSbntQCkFU6EuZlrlDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-09T04:33:00.426960Z"},"content_sha256":"1e571838e455cec00991cf53145df9d6a4f039fbc892d571b3a9a64f6f72184a","schema_version":"1.0","event_id":"sha256:1e571838e455cec00991cf53145df9d6a4f039fbc892d571b3a9a64f6f72184a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UPQFUAXEQ3MHBEBGNCP2WHTD2F/bundle.json","state_url":"https://pith.science/pith/UPQFUAXEQ3MHBEBGNCP2WHTD2F/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UPQFUAXEQ3MHBEBGNCP2WHTD2F/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-09T04:33:00Z","links":{"resolver":"https://pith.science/pith/UPQFUAXEQ3MHBEBGNCP2WHTD2F","bundle":"https://pith.science/pith/UPQFUAXEQ3MHBEBGNCP2WHTD2F/bundle.json","state":"https://pith.science/pith/UPQFUAXEQ3MHBEBGNCP2WHTD2F/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UPQFUAXEQ3MHBEBGNCP2WHTD2F/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:UPQFUAXEQ3MHBEBGNCP2WHTD2F","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f72e44a8714fd6346049406c01a25b399743d49bdd5f613143ee2ec83d21be63","cross_cats_sorted":["q-bio.TO"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-14T23:03:00Z","title_canon_sha256":"0b2c1fb157913359cbc3ea6ea1e374cf376863c0d3e81fcf69a453f4e8548713"},"schema_version":"1.0","source":{"id":"2112.07780","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2112.07780","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"arxiv_version","alias_value":"2112.07780v1","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2112.07780","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"pith_short_12","alias_value":"UPQFUAXEQ3MH","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"pith_short_16","alias_value":"UPQFUAXEQ3MHBEBG","created_at":"2026-07-05T03:41:06Z"},{"alias_kind":"pith_short_8","alias_value":"UPQFUAXE","created_at":"2026-07-05T03:41:06Z"}],"graph_snapshots":[{"event_id":"sha256:1e571838e455cec00991cf53145df9d6a4f039fbc892d571b3a9a64f6f72184a","target":"graph","created_at":"2026-07-05T03:41:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2112.07780/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Purpose: This study is to test the feasibility of optical coherence tomography (OCT) detection of photoreceptor abnormality and to verify the photoreceptor abnormality is rod predominated in early DR . Methods: OCT images were acquired from normal eyes, diabetic eyes with no diabetic retinopathy (NoDR) and mild DR. Quantitative features, including length features quantifying band distances and reflectance intensity features among the external limiting membrane (ELM), inner segment ellipsoid (ISe), interdigitation zone (IZ) and retinal pigment epithelium (RPE) were determined. Comparative OCT a","authors_text":"David Le, Jennifer I. Lim, Taeyoon Son, Xincheng Yao","cross_cats":["q-bio.TO"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-14T23:03:00Z","title":"Quantitative optical coherence tomography reveals rod photoreceptor degeneration in early diabetic retinopathy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2112.07780","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f98829b635e9b03ea2ac203fc321cc0412fd449e185c6accdc83950dbf0c9d59","target":"record","created_at":"2026-07-05T03:41:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f72e44a8714fd6346049406c01a25b399743d49bdd5f613143ee2ec83d21be63","cross_cats_sorted":["q-bio.TO"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-12-14T23:03:00Z","title_canon_sha256":"0b2c1fb157913359cbc3ea6ea1e374cf376863c0d3e81fcf69a453f4e8548713"},"schema_version":"1.0","source":{"id":"2112.07780","kind":"arxiv","version":1}},"canonical_sha256":"a3e05a02e486d8709026689fab1e63d17561a77dde779fe09c0675786447cd61","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a3e05a02e486d8709026689fab1e63d17561a77dde779fe09c0675786447cd61","first_computed_at":"2026-07-05T03:41:06.416086Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:41:06.416086Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"MYV4q62GtPbRmw5+K/PVuK7yI/raniyiyub7pnUDrZ219hYdaXU4HhyXE0O0WUFFLaP3WSa0COTidKYpY0nZCA==","signature_status":"signed_v1","signed_at":"2026-07-05T03:41:06.416495Z","signed_message":"canonical_sha256_bytes"},"source_id":"2112.07780","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f98829b635e9b03ea2ac203fc321cc0412fd449e185c6accdc83950dbf0c9d59","sha256:1e571838e455cec00991cf53145df9d6a4f039fbc892d571b3a9a64f6f72184a"],"state_sha256":"3acdd74735d2f2f5c9f061edd89d08151507e457f9bdc0b09c80a96f198c3a13"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"awput36suzpM3ddWTj6wa1RjBnkYoPnxcjTccCF2BgiWlj9pdurVRxoIENrR+7vgkif39c5cytmr00NLYX8bCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-09T04:33:00.428873Z","bundle_sha256":"57dabfa9108f6814353bf30de18d03a4ac0a7058010e423ddc9bbbc40491feff"}}