{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:UUV2HCCXQQ44UMWTJBEKRJNHTD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9c0695566e45573d574703cafe5dfc97d3024024d6d9c6f8436bd02edda7c6e8","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2026-05-27T09:41:07Z","title_canon_sha256":"fc9fe54a13e6e71ad074b79c0f5d12f7e803c49fe0d78cb5d5868c8c55e00bc3"},"schema_version":"1.0","source":{"id":"2605.28226","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2605.28226","created_at":"2026-05-28T01:05:03Z"},{"alias_kind":"arxiv_version","alias_value":"2605.28226v1","created_at":"2026-05-28T01:05:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2605.28226","created_at":"2026-05-28T01:05:03Z"},{"alias_kind":"pith_short_12","alias_value":"UUV2HCCXQQ44","created_at":"2026-05-28T01:05:03Z"},{"alias_kind":"pith_short_16","alias_value":"UUV2HCCXQQ44UMWT","created_at":"2026-05-28T01:05:03Z"},{"alias_kind":"pith_short_8","alias_value":"UUV2HCCX","created_at":"2026-05-28T01:05:03Z"}],"graph_snapshots":[{"event_id":"sha256:32a4c163ab74ef91c5c5ff1ebbadab718d547dedc97207e08b6e4b250412a3be","target":"graph","created_at":"2026-05-28T01:05:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2605.28226/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Small-molecule drug discovery requires simultaneous optimization of numerous properties of candidate molecules. These properties can be investigated through the analysis of high-dimensional biological signatures, such as cell morphology and transcriptomic perturbations, which provide a rich perspective on the underlying biological mechanisms. However, existing generative methods, which use those signatures for optimization, fail to meet two key requirements: providing precise guidance toward desired phenotypic signatures while maintaining structural proximity to a known hit. We introduce PhAME","authors_text":"Bartosz Zieli\\'nski, Dawid Rymarczyk, {\\L}ukasz Janisi\\'ow, Sebastian Musia{\\l}, Tomasz Danel","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2026-05-27T09:41:07Z","title":"PhAME: Phenotype-Aware Molecular Editing via Latent Diffusion"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2605.28226","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6d4c24c109acf88754b6ed5a1495c3e21a7e1bdb77dde0e51529de2750415698","target":"record","created_at":"2026-05-28T01:05:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9c0695566e45573d574703cafe5dfc97d3024024d6d9c6f8436bd02edda7c6e8","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2026-05-27T09:41:07Z","title_canon_sha256":"fc9fe54a13e6e71ad074b79c0f5d12f7e803c49fe0d78cb5d5868c8c55e00bc3"},"schema_version":"1.0","source":{"id":"2605.28226","kind":"arxiv","version":1}},"canonical_sha256":"a52ba388578439ca32d34848a8a5a798f26b49a83169f08e8853f98620b531e5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a52ba388578439ca32d34848a8a5a798f26b49a83169f08e8853f98620b531e5","first_computed_at":"2026-05-28T01:05:03.188893Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-28T01:05:03.188893Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"FOu5UZ2OvxNZs2BU4CLSyxIiyCe8a6rzgUAXCilKZXpaQUTf+EaCMfQGUM1gM3HL4bJ07MQtuFjmu1/8icTJBA==","signature_status":"signed_v1","signed_at":"2026-05-28T01:05:03.189389Z","signed_message":"canonical_sha256_bytes"},"source_id":"2605.28226","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6d4c24c109acf88754b6ed5a1495c3e21a7e1bdb77dde0e51529de2750415698","sha256:32a4c163ab74ef91c5c5ff1ebbadab718d547dedc97207e08b6e4b250412a3be"],"state_sha256":"39901fe59ec5e1e6edb120cedf49c03106f24dfb3aa1f1a7fc4e61ebd05a533a"}