{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:UV4MYHJ3AP4I3G6JJF26TUULDY","short_pith_number":"pith:UV4MYHJ3","canonical_record":{"source":{"id":"2103.08082","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CV","submitted_at":"2021-03-15T00:53:47Z","cross_cats_sorted":[],"title_canon_sha256":"23342724c291210b86a8cb1cfbadd2593c19c0e389ebaff05a21c92af1f00ada","abstract_canon_sha256":"767090803d4ced6cc2706d1d837cfdb0f2474592ca119f07bb75a2889b1c290c"},"schema_version":"1.0"},"canonical_sha256":"a578cc1d3b03f88d9bc94975e9d28b1e176dd883ddb971e84c31fadd8e56f763","source":{"kind":"arxiv","id":"2103.08082","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2103.08082","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"arxiv_version","alias_value":"2103.08082v1","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2103.08082","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"pith_short_12","alias_value":"UV4MYHJ3AP4I","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"pith_short_16","alias_value":"UV4MYHJ3AP4I3G6J","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"pith_short_8","alias_value":"UV4MYHJ3","created_at":"2026-07-05T02:22:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:UV4MYHJ3AP4I3G6JJF26TUULDY","target":"record","payload":{"canonical_record":{"source":{"id":"2103.08082","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CV","submitted_at":"2021-03-15T00:53:47Z","cross_cats_sorted":[],"title_canon_sha256":"23342724c291210b86a8cb1cfbadd2593c19c0e389ebaff05a21c92af1f00ada","abstract_canon_sha256":"767090803d4ced6cc2706d1d837cfdb0f2474592ca119f07bb75a2889b1c290c"},"schema_version":"1.0"},"canonical_sha256":"a578cc1d3b03f88d9bc94975e9d28b1e176dd883ddb971e84c31fadd8e56f763","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:22:47.712353Z","signature_b64":"ayPas8H28KBYzLcclmMlhe3GBgbrfVxQYLYsejr5rcz/cylyOIE0TeOWYdne+uDwsBaMmbWClQSvJqlMHuuHCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a578cc1d3b03f88d9bc94975e9d28b1e176dd883ddb971e84c31fadd8e56f763","last_reissued_at":"2026-07-05T02:22:47.711828Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:22:47.711828Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2103.08082","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:22:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Y7FKHKNdcVJ+jAEatBcUpVvzPKo+R+gmrJM3Y90vmAeTtskolmefAxo5/dPpuX+/J2trT0ymQgTz4C7ejfznAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T11:13:45.110537Z"},"content_sha256":"ac65e6676035e68b58441d331136e07fc34e94c8aac44d594fbf6d8ce7c7939f","schema_version":"1.0","event_id":"sha256:ac65e6676035e68b58441d331136e07fc34e94c8aac44d594fbf6d8ce7c7939f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:UV4MYHJ3AP4I3G6JJF26TUULDY","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Exploring Genetic-histologic Relationships in Breast Cancer","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"cs.CV","authors_text":"CV Jawahar, PK Vinod, Ruchi Chauhan","submitted_at":"2021-03-15T00:53:47Z","abstract_excerpt":"The advent of digital pathology presents opportunities for computer vision for fast, accurate, and objective solutions for histopathological images and aid in knowledge discovery. This work uses deep learning to predict genomic biomarkers - TP53 mutation, PIK3CA mutation, ER status, PR status, HER2 status, and intrinsic subtypes, from breast cancer histopathology images. Furthermore, we attempt to understand the underlying morphology as to how these genomic biomarkers manifest in images. Since gene sequencing is expensive, not always available, or even feasible, predicting these biomarkers fro"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2103.08082","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2103.08082/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:22:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+9ESaN6KyHsE7NuaBMCZYz3IrKPOvSLVnCIeYyJh8EHxjYNbbFA9FgKQikWPHSj0jKvXABe/JRuuJbXcVN8SDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T11:13:45.110917Z"},"content_sha256":"0811bed431d86c9209ed2df6a0f3cf6039556f730eef9d67bd5650d902539629","schema_version":"1.0","event_id":"sha256:0811bed431d86c9209ed2df6a0f3cf6039556f730eef9d67bd5650d902539629"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UV4MYHJ3AP4I3G6JJF26TUULDY/bundle.json","state_url":"https://pith.science/pith/UV4MYHJ3AP4I3G6JJF26TUULDY/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UV4MYHJ3AP4I3G6JJF26TUULDY/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-19T11:13:45Z","links":{"resolver":"https://pith.science/pith/UV4MYHJ3AP4I3G6JJF26TUULDY","bundle":"https://pith.science/pith/UV4MYHJ3AP4I3G6JJF26TUULDY/bundle.json","state":"https://pith.science/pith/UV4MYHJ3AP4I3G6JJF26TUULDY/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UV4MYHJ3AP4I3G6JJF26TUULDY/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:UV4MYHJ3AP4I3G6JJF26TUULDY","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"767090803d4ced6cc2706d1d837cfdb0f2474592ca119f07bb75a2889b1c290c","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CV","submitted_at":"2021-03-15T00:53:47Z","title_canon_sha256":"23342724c291210b86a8cb1cfbadd2593c19c0e389ebaff05a21c92af1f00ada"},"schema_version":"1.0","source":{"id":"2103.08082","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2103.08082","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"arxiv_version","alias_value":"2103.08082v1","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2103.08082","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"pith_short_12","alias_value":"UV4MYHJ3AP4I","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"pith_short_16","alias_value":"UV4MYHJ3AP4I3G6J","created_at":"2026-07-05T02:22:47Z"},{"alias_kind":"pith_short_8","alias_value":"UV4MYHJ3","created_at":"2026-07-05T02:22:47Z"}],"graph_snapshots":[{"event_id":"sha256:0811bed431d86c9209ed2df6a0f3cf6039556f730eef9d67bd5650d902539629","target":"graph","created_at":"2026-07-05T02:22:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2103.08082/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The advent of digital pathology presents opportunities for computer vision for fast, accurate, and objective solutions for histopathological images and aid in knowledge discovery. This work uses deep learning to predict genomic biomarkers - TP53 mutation, PIK3CA mutation, ER status, PR status, HER2 status, and intrinsic subtypes, from breast cancer histopathology images. Furthermore, we attempt to understand the underlying morphology as to how these genomic biomarkers manifest in images. Since gene sequencing is expensive, not always available, or even feasible, predicting these biomarkers fro","authors_text":"CV Jawahar, PK Vinod, Ruchi Chauhan","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CV","submitted_at":"2021-03-15T00:53:47Z","title":"Exploring Genetic-histologic Relationships in Breast Cancer"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2103.08082","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ac65e6676035e68b58441d331136e07fc34e94c8aac44d594fbf6d8ce7c7939f","target":"record","created_at":"2026-07-05T02:22:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"767090803d4ced6cc2706d1d837cfdb0f2474592ca119f07bb75a2889b1c290c","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CV","submitted_at":"2021-03-15T00:53:47Z","title_canon_sha256":"23342724c291210b86a8cb1cfbadd2593c19c0e389ebaff05a21c92af1f00ada"},"schema_version":"1.0","source":{"id":"2103.08082","kind":"arxiv","version":1}},"canonical_sha256":"a578cc1d3b03f88d9bc94975e9d28b1e176dd883ddb971e84c31fadd8e56f763","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a578cc1d3b03f88d9bc94975e9d28b1e176dd883ddb971e84c31fadd8e56f763","first_computed_at":"2026-07-05T02:22:47.711828Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:22:47.711828Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ayPas8H28KBYzLcclmMlhe3GBgbrfVxQYLYsejr5rcz/cylyOIE0TeOWYdne+uDwsBaMmbWClQSvJqlMHuuHCw==","signature_status":"signed_v1","signed_at":"2026-07-05T02:22:47.712353Z","signed_message":"canonical_sha256_bytes"},"source_id":"2103.08082","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ac65e6676035e68b58441d331136e07fc34e94c8aac44d594fbf6d8ce7c7939f","sha256:0811bed431d86c9209ed2df6a0f3cf6039556f730eef9d67bd5650d902539629"],"state_sha256":"1671fca58eb220624216c326afa32c2bed80b8612952ca841dc3784f83ba3576"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Kq3MbNQvBDI2RUi8yuA2ms57p5QeEXD5L+vO2NT5CEm7VfPHPQd358wlpNSXyL6fiI3FRPjumCKtAl6Tk1MxAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-19T11:13:45.113368Z","bundle_sha256":"68253691f7eb0ed1caa8ebedeb7789202f06d1d1edad4b9f64f2bbc392b20929"}}