{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:UVCBSDSIJ7BUCSLDX5EEVNO4FM","short_pith_number":"pith:UVCBSDSI","canonical_record":{"source":{"id":"1902.09939","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-02-26T14:04:08Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"33a898fc45e95876402bef52fbac5d2269bd146b51888e16c5bb04be61c1266a","abstract_canon_sha256":"aec57b3d72211dcbf97de30395ed9b69ece48d2dc6b44415de353dabc14604e9"},"schema_version":"1.0"},"canonical_sha256":"a544190e484fc3414963bf484ab5dc2b152c4616293372631bfd36b67485d090","source":{"kind":"arxiv","id":"1902.09939","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1902.09939","created_at":"2026-05-17T23:52:35Z"},{"alias_kind":"arxiv_version","alias_value":"1902.09939v1","created_at":"2026-05-17T23:52:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1902.09939","created_at":"2026-05-17T23:52:35Z"},{"alias_kind":"pith_short_12","alias_value":"UVCBSDSIJ7BU","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_16","alias_value":"UVCBSDSIJ7BUCSLD","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_8","alias_value":"UVCBSDSI","created_at":"2026-05-18T12:33:30Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:UVCBSDSIJ7BUCSLDX5EEVNO4FM","target":"record","payload":{"canonical_record":{"source":{"id":"1902.09939","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-02-26T14:04:08Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"33a898fc45e95876402bef52fbac5d2269bd146b51888e16c5bb04be61c1266a","abstract_canon_sha256":"aec57b3d72211dcbf97de30395ed9b69ece48d2dc6b44415de353dabc14604e9"},"schema_version":"1.0"},"canonical_sha256":"a544190e484fc3414963bf484ab5dc2b152c4616293372631bfd36b67485d090","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:52:35.011096Z","signature_b64":"IiOKqQV69fZ0DPUbJBx4wb9tT2/BUiBLcm2P69ZbH2TaD8Dl3Ui9JYRFSzMOCP7nUnJUvH3iPkRMYtjKF2MGBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a544190e484fc3414963bf484ab5dc2b152c4616293372631bfd36b67485d090","last_reissued_at":"2026-05-17T23:52:35.010743Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:52:35.010743Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1902.09939","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:52:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0JR5nk6zhnPwV5x56yu5IHdRdQRf0c98f/Cz35o36KqWvCpE66oAfU4Bd5+K7blDQ1rIhagQlJcHApYRo0CHBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T23:04:50.309371Z"},"content_sha256":"f1066e8b3e9895048b6fe28ce58501e6fc6b5edfa2a5f24585377562e960b065","schema_version":"1.0","event_id":"sha256:f1066e8b3e9895048b6fe28ce58501e6fc6b5edfa2a5f24585377562e960b065"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:UVCBSDSIJ7BUCSLDX5EEVNO4FM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Universality of fold-encoded localized vibrations in enzymes","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Claude Weisbuch, Francesco Piazza, Marcel Filoche, Svitlana Mayboroda, Yann Chalopin","submitted_at":"2019-02-26T14:04:08Z","abstract_excerpt":"Enzymes speed up biochemical reactions at the core of life by as much as 15 orders of magnitude. Yet, despite considerable advances, the fine dynamical determinants at the microscopic level of their catalytic proficiency are still elusive. In this work, we use a powerful mathematical approach to show that rate-promoting vibrations in the picosecond range, specifically encoded in the 3D protein structure, are localized vibrations optimally coupled to the chemical reaction coordinates at the active site. The universality of these features is demonstrated on a pool of more than 900 enzyme structu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1902.09939","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:52:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ztP80Aow93/dIeeHleVjvbyzwUmuwIVe/tHQevqZ9AGRQ9/qu/C3B31dU2kY7UOF+5TPOrW94gX769fl3IusBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T23:04:50.309986Z"},"content_sha256":"e13752cad6e814e32305d7e05afa5e99ff60f45bbc699c8bf0d18128f4350989","schema_version":"1.0","event_id":"sha256:e13752cad6e814e32305d7e05afa5e99ff60f45bbc699c8bf0d18128f4350989"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UVCBSDSIJ7BUCSLDX5EEVNO4FM/bundle.json","state_url":"https://pith.science/pith/UVCBSDSIJ7BUCSLDX5EEVNO4FM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UVCBSDSIJ7BUCSLDX5EEVNO4FM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T23:04:50Z","links":{"resolver":"https://pith.science/pith/UVCBSDSIJ7BUCSLDX5EEVNO4FM","bundle":"https://pith.science/pith/UVCBSDSIJ7BUCSLDX5EEVNO4FM/bundle.json","state":"https://pith.science/pith/UVCBSDSIJ7BUCSLDX5EEVNO4FM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UVCBSDSIJ7BUCSLDX5EEVNO4FM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:UVCBSDSIJ7BUCSLDX5EEVNO4FM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"aec57b3d72211dcbf97de30395ed9b69ece48d2dc6b44415de353dabc14604e9","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-02-26T14:04:08Z","title_canon_sha256":"33a898fc45e95876402bef52fbac5d2269bd146b51888e16c5bb04be61c1266a"},"schema_version":"1.0","source":{"id":"1902.09939","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1902.09939","created_at":"2026-05-17T23:52:35Z"},{"alias_kind":"arxiv_version","alias_value":"1902.09939v1","created_at":"2026-05-17T23:52:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1902.09939","created_at":"2026-05-17T23:52:35Z"},{"alias_kind":"pith_short_12","alias_value":"UVCBSDSIJ7BU","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_16","alias_value":"UVCBSDSIJ7BUCSLD","created_at":"2026-05-18T12:33:30Z"},{"alias_kind":"pith_short_8","alias_value":"UVCBSDSI","created_at":"2026-05-18T12:33:30Z"}],"graph_snapshots":[{"event_id":"sha256:e13752cad6e814e32305d7e05afa5e99ff60f45bbc699c8bf0d18128f4350989","target":"graph","created_at":"2026-05-17T23:52:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Enzymes speed up biochemical reactions at the core of life by as much as 15 orders of magnitude. Yet, despite considerable advances, the fine dynamical determinants at the microscopic level of their catalytic proficiency are still elusive. In this work, we use a powerful mathematical approach to show that rate-promoting vibrations in the picosecond range, specifically encoded in the 3D protein structure, are localized vibrations optimally coupled to the chemical reaction coordinates at the active site. The universality of these features is demonstrated on a pool of more than 900 enzyme structu","authors_text":"Claude Weisbuch, Francesco Piazza, Marcel Filoche, Svitlana Mayboroda, Yann Chalopin","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-02-26T14:04:08Z","title":"Universality of fold-encoded localized vibrations in enzymes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1902.09939","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f1066e8b3e9895048b6fe28ce58501e6fc6b5edfa2a5f24585377562e960b065","target":"record","created_at":"2026-05-17T23:52:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"aec57b3d72211dcbf97de30395ed9b69ece48d2dc6b44415de353dabc14604e9","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-02-26T14:04:08Z","title_canon_sha256":"33a898fc45e95876402bef52fbac5d2269bd146b51888e16c5bb04be61c1266a"},"schema_version":"1.0","source":{"id":"1902.09939","kind":"arxiv","version":1}},"canonical_sha256":"a544190e484fc3414963bf484ab5dc2b152c4616293372631bfd36b67485d090","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a544190e484fc3414963bf484ab5dc2b152c4616293372631bfd36b67485d090","first_computed_at":"2026-05-17T23:52:35.010743Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:52:35.010743Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"IiOKqQV69fZ0DPUbJBx4wb9tT2/BUiBLcm2P69ZbH2TaD8Dl3Ui9JYRFSzMOCP7nUnJUvH3iPkRMYtjKF2MGBA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:52:35.011096Z","signed_message":"canonical_sha256_bytes"},"source_id":"1902.09939","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f1066e8b3e9895048b6fe28ce58501e6fc6b5edfa2a5f24585377562e960b065","sha256:e13752cad6e814e32305d7e05afa5e99ff60f45bbc699c8bf0d18128f4350989"],"state_sha256":"7e051f6f05e3620f7dabf6e85fa07cd9a591212d6f35ed9cabec17b55efa7bf0"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"tIFK//asazC2hXBBP/nMmQTjuushIp683pCi+Ks2Bhc796uBQTXojL4Dw0cdpPkCHp2XE3GllGIL+W0antH1AQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T23:04:50.313552Z","bundle_sha256":"585324b873c1365e2bd9842288caeb3fd23e1c837a0f829f79f7a09483f22e2c"}}