{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:UVKNUDPZ7SQHOHLEX6LNXE6RB2","short_pith_number":"pith:UVKNUDPZ","canonical_record":{"source":{"id":"2607.06224","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-07T12:48:38Z","cross_cats_sorted":[],"title_canon_sha256":"35f109615b1c51030f86720c6733763a336ba2377d8717e06403fb9e290856c4","abstract_canon_sha256":"8468ea12c7d52b5424c32f97bbcd9dd6fe901a1865ce6d3ee749068767f145f0"},"schema_version":"1.0"},"canonical_sha256":"a554da0df9fca0771d64bf96db93d10eaedcc9c3a3e860089bd3dabb1143028a","source":{"kind":"arxiv","id":"2607.06224","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.06224","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"arxiv_version","alias_value":"2607.06224v1","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.06224","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"pith_short_12","alias_value":"UVKNUDPZ7SQH","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"pith_short_16","alias_value":"UVKNUDPZ7SQHOHLE","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"pith_short_8","alias_value":"UVKNUDPZ","created_at":"2026-07-08T01:19:18Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:UVKNUDPZ7SQHOHLEX6LNXE6RB2","target":"record","payload":{"canonical_record":{"source":{"id":"2607.06224","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-07T12:48:38Z","cross_cats_sorted":[],"title_canon_sha256":"35f109615b1c51030f86720c6733763a336ba2377d8717e06403fb9e290856c4","abstract_canon_sha256":"8468ea12c7d52b5424c32f97bbcd9dd6fe901a1865ce6d3ee749068767f145f0"},"schema_version":"1.0"},"canonical_sha256":"a554da0df9fca0771d64bf96db93d10eaedcc9c3a3e860089bd3dabb1143028a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-08T01:19:18.293006Z","signature_b64":"P1oCXs1KwxkVni+yWET7Ij/AKYeZfOTt0iDXXIexzHY3rYPU4F1XRhyT4juO8MLOBW7H5PTmwms6Xd3sMLrVAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"a554da0df9fca0771d64bf96db93d10eaedcc9c3a3e860089bd3dabb1143028a","last_reissued_at":"2026-07-08T01:19:18.292370Z","signature_status":"signed_v1","first_computed_at":"2026-07-08T01:19:18.292370Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2607.06224","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-08T01:19:18Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"csl6fn/1nf59JGAOItBhCLWd2slva9ja6S0ZC2EB79UWLa+2FmtiEqwE1NFx+VnHChkSE0GIimtM8ktCJ0ElDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-12T14:04:37.631469Z"},"content_sha256":"f342b248d6ce10d37aee0e6bab100b9ec3741b51bde46f1cb130090d5af21e18","schema_version":"1.0","event_id":"sha256:f342b248d6ce10d37aee0e6bab100b9ec3741b51bde46f1cb130090d5af21e18"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:UVKNUDPZ7SQHOHLEX6LNXE6RB2","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Canopy: A Heterograph Foundation Model for Metabolic Engineering","license":"http://creativecommons.org/licenses/by-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"cs.LG","authors_text":"Jake Bowden, Laurence Legon, Satnam Surae","submitted_at":"2026-07-07T12:48:38Z","abstract_excerpt":"Designing microbial strains that produce high-value chemicals at commercially viable titers remains a central challenge in metabolic engineering. Existing computational approaches either rely on stoichiometric constraint-based models that cannot learn from experimental data, or apply tabular machine learning to hand-crafted features that discard the relational structure of biological knowledge. We present Canopy, a heterogeneous graph foundation model that integrates ten public and proprietary data sources into a unified knowledge graph (KG) of 6.9M nodes across 13 types and 34 edge types, cov"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.06224","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.06224/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-08T01:19:18Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"v8SywQR8zPgUyLB4MZsEWxIUpWys2asvTdM6Hx6MsFwbjqiGVeAAeXbg+9Rm7Yi2SGo9/PgfGpBKJfkQL9w1Aw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-12T14:04:37.638603Z"},"content_sha256":"ea09833d9062c5742c6fcd2a2d05f6c44acecf39dc61ea7b79f1555856dabbb6","schema_version":"1.0","event_id":"sha256:ea09833d9062c5742c6fcd2a2d05f6c44acecf39dc61ea7b79f1555856dabbb6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/UVKNUDPZ7SQHOHLEX6LNXE6RB2/bundle.json","state_url":"https://pith.science/pith/UVKNUDPZ7SQHOHLEX6LNXE6RB2/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/UVKNUDPZ7SQHOHLEX6LNXE6RB2/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-12T14:04:37Z","links":{"resolver":"https://pith.science/pith/UVKNUDPZ7SQHOHLEX6LNXE6RB2","bundle":"https://pith.science/pith/UVKNUDPZ7SQHOHLEX6LNXE6RB2/bundle.json","state":"https://pith.science/pith/UVKNUDPZ7SQHOHLEX6LNXE6RB2/state.json","well_known_bundle":"https://pith.science/.well-known/pith/UVKNUDPZ7SQHOHLEX6LNXE6RB2/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:UVKNUDPZ7SQHOHLEX6LNXE6RB2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8468ea12c7d52b5424c32f97bbcd9dd6fe901a1865ce6d3ee749068767f145f0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-07T12:48:38Z","title_canon_sha256":"35f109615b1c51030f86720c6733763a336ba2377d8717e06403fb9e290856c4"},"schema_version":"1.0","source":{"id":"2607.06224","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.06224","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"arxiv_version","alias_value":"2607.06224v1","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.06224","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"pith_short_12","alias_value":"UVKNUDPZ7SQH","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"pith_short_16","alias_value":"UVKNUDPZ7SQHOHLE","created_at":"2026-07-08T01:19:18Z"},{"alias_kind":"pith_short_8","alias_value":"UVKNUDPZ","created_at":"2026-07-08T01:19:18Z"}],"graph_snapshots":[{"event_id":"sha256:ea09833d9062c5742c6fcd2a2d05f6c44acecf39dc61ea7b79f1555856dabbb6","target":"graph","created_at":"2026-07-08T01:19:18Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2607.06224/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Designing microbial strains that produce high-value chemicals at commercially viable titers remains a central challenge in metabolic engineering. Existing computational approaches either rely on stoichiometric constraint-based models that cannot learn from experimental data, or apply tabular machine learning to hand-crafted features that discard the relational structure of biological knowledge. We present Canopy, a heterogeneous graph foundation model that integrates ten public and proprietary data sources into a unified knowledge graph (KG) of 6.9M nodes across 13 types and 34 edge types, cov","authors_text":"Jake Bowden, Laurence Legon, Satnam Surae","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-07T12:48:38Z","title":"Canopy: A Heterograph Foundation Model for Metabolic Engineering"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.06224","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f342b248d6ce10d37aee0e6bab100b9ec3741b51bde46f1cb130090d5af21e18","target":"record","created_at":"2026-07-08T01:19:18Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8468ea12c7d52b5424c32f97bbcd9dd6fe901a1865ce6d3ee749068767f145f0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2026-07-07T12:48:38Z","title_canon_sha256":"35f109615b1c51030f86720c6733763a336ba2377d8717e06403fb9e290856c4"},"schema_version":"1.0","source":{"id":"2607.06224","kind":"arxiv","version":1}},"canonical_sha256":"a554da0df9fca0771d64bf96db93d10eaedcc9c3a3e860089bd3dabb1143028a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a554da0df9fca0771d64bf96db93d10eaedcc9c3a3e860089bd3dabb1143028a","first_computed_at":"2026-07-08T01:19:18.292370Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-08T01:19:18.292370Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"P1oCXs1KwxkVni+yWET7Ij/AKYeZfOTt0iDXXIexzHY3rYPU4F1XRhyT4juO8MLOBW7H5PTmwms6Xd3sMLrVAg==","signature_status":"signed_v1","signed_at":"2026-07-08T01:19:18.293006Z","signed_message":"canonical_sha256_bytes"},"source_id":"2607.06224","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f342b248d6ce10d37aee0e6bab100b9ec3741b51bde46f1cb130090d5af21e18","sha256:ea09833d9062c5742c6fcd2a2d05f6c44acecf39dc61ea7b79f1555856dabbb6"],"state_sha256":"151677b827e41363bb7d2b2199baf2a8657349967e1193add8839a56e0ed08e1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"C4TECvUWMoCiEguEdpqUMUULXuaS0YPIc2fmj3q6qMk6AnPhjN9IIpe4h4+mZuIWHP1FSqw8FmGA56o3v+FTBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-12T14:04:37.722704Z","bundle_sha256":"62b89952d76ba54dd6507a56c9191f0c927b19b42ff732a262acdb72650f6939"}}