{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:UYW3BJS2WDXTG6W6GB5DKRTI4Q","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"404f1d4ff3beb40f4665105504b2d4461ba1f9a3e77bacd3f92adb25096e3067","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-06T16:47:18Z","title_canon_sha256":"6d59ca94aa725a2d5295b3a72361e4fe7a44a038e071dc5cb00b0586a8d14a82"},"schema_version":"1.0","source":{"id":"2607.05306","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.05306","created_at":"2026-07-07T03:19:22Z"},{"alias_kind":"arxiv_version","alias_value":"2607.05306v1","created_at":"2026-07-07T03:19:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.05306","created_at":"2026-07-07T03:19:22Z"},{"alias_kind":"pith_short_12","alias_value":"UYW3BJS2WDXT","created_at":"2026-07-07T03:19:22Z"},{"alias_kind":"pith_short_16","alias_value":"UYW3BJS2WDXTG6W6","created_at":"2026-07-07T03:19:22Z"},{"alias_kind":"pith_short_8","alias_value":"UYW3BJS2","created_at":"2026-07-07T03:19:22Z"}],"graph_snapshots":[{"event_id":"sha256:a7804e2a1a863862c0c7020b09612a3c9c88eb5f33de9d8ff92f4f43dcb44d8a","target":"graph","created_at":"2026-07-07T03:19:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2607.05306/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Integrating complex, multi-omics data presents significant challenges. Existing approaches often face a trade-off between model interpretability and representational capacity, with most either relying on post-hoc interpretation or use linear models that may overlook complex interactions. We report Pathway Activity Autoencoders for the multi-omics setting, which embed prior knowledge via pathway-informed architectural constraints, fostering interpretability, while preserving representational power. Our multi-omic framework is applied in the context of breast cancer and is evaluated in survival ","authors_text":"Le Ou-Yang, Min Wu, Pedro Henrique da Costa Avelar, Sophia Tsoka","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-06T16:47:18Z","title":"Biologically Informed Deep Neural Networks for Multi-Omic Integration, Pathway Activity Inference and Risk Stratification in Cancer"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.05306","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6cb3f3fa14758731b81363093edf2c0877dd542f7a7332979c9a8eb7082b287f","target":"record","created_at":"2026-07-07T03:19:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"404f1d4ff3beb40f4665105504b2d4461ba1f9a3e77bacd3f92adb25096e3067","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-06T16:47:18Z","title_canon_sha256":"6d59ca94aa725a2d5295b3a72361e4fe7a44a038e071dc5cb00b0586a8d14a82"},"schema_version":"1.0","source":{"id":"2607.05306","kind":"arxiv","version":1}},"canonical_sha256":"a62db0a65ab0ef337ade307a354668e426ff3ade9ef881c3735d1a320754d5b2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"a62db0a65ab0ef337ade307a354668e426ff3ade9ef881c3735d1a320754d5b2","first_computed_at":"2026-07-07T03:19:22.952506Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-07T03:19:22.952506Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"2/LY9hhY22dug8pAPxsfjtCvtcECz0dw6nFXiYYNzuMxypso+bGv0FU6ZBsFPGj6EGF7t1zlPgUgSlu5OgT4CQ==","signature_status":"signed_v1","signed_at":"2026-07-07T03:19:22.952947Z","signed_message":"canonical_sha256_bytes"},"source_id":"2607.05306","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6cb3f3fa14758731b81363093edf2c0877dd542f7a7332979c9a8eb7082b287f","sha256:a7804e2a1a863862c0c7020b09612a3c9c88eb5f33de9d8ff92f4f43dcb44d8a"],"state_sha256":"44fc40de8dc864fea05247d7dc54902e83a2b2461dfccd8be1950fb82c5fda37"}