{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:V25M46FDXCJ435A62MUDS2ZPMX","short_pith_number":"pith:V25M46FD","canonical_record":{"source":{"id":"1508.02172","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2015-08-10T09:02:15Z","cross_cats_sorted":[],"title_canon_sha256":"41cc3f877a10bc4f85ba7e789c562f48b27e780874ffbc642a95b0dfc3c39458","abstract_canon_sha256":"67f952c60ef1570c22b2fce3f7785e0636ce6eb36022ff93deae0655df6bf4ed"},"schema_version":"1.0"},"canonical_sha256":"aebace78a3b893cdf41ed328396b2f65c2700c92095c2535894ff1df1d9e52b2","source":{"kind":"arxiv","id":"1508.02172","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1508.02172","created_at":"2026-05-18T01:35:33Z"},{"alias_kind":"arxiv_version","alias_value":"1508.02172v1","created_at":"2026-05-18T01:35:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1508.02172","created_at":"2026-05-18T01:35:33Z"},{"alias_kind":"pith_short_12","alias_value":"V25M46FDXCJ4","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_16","alias_value":"V25M46FDXCJ435A6","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_8","alias_value":"V25M46FD","created_at":"2026-05-18T12:29:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:V25M46FDXCJ435A62MUDS2ZPMX","target":"record","payload":{"canonical_record":{"source":{"id":"1508.02172","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2015-08-10T09:02:15Z","cross_cats_sorted":[],"title_canon_sha256":"41cc3f877a10bc4f85ba7e789c562f48b27e780874ffbc642a95b0dfc3c39458","abstract_canon_sha256":"67f952c60ef1570c22b2fce3f7785e0636ce6eb36022ff93deae0655df6bf4ed"},"schema_version":"1.0"},"canonical_sha256":"aebace78a3b893cdf41ed328396b2f65c2700c92095c2535894ff1df1d9e52b2","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:35:33.967804Z","signature_b64":"iGw3Ki8vlrEKCfeb34jw12RR7jUiCrs9tfjFHpvv1EY62JTRkJVsnw1v9vWi2p4C9B1OGzkFenQ3Sqg2LNPCDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"aebace78a3b893cdf41ed328396b2f65c2700c92095c2535894ff1df1d9e52b2","last_reissued_at":"2026-05-18T01:35:33.967060Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:35:33.967060Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1508.02172","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:35:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Jb4npFMSkh9sTEQ9V8gd3i8DAJolALswvQcZBY1RzP0DFteEwgGaE8YMK0lRjeS2NeInWLT0hlSzkgHHz9otAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T18:25:45.246990Z"},"content_sha256":"2919410126ac8704fadc4178e9e324aebe6e1c8c21163303287477a9ddf29157","schema_version":"1.0","event_id":"sha256:2919410126ac8704fadc4178e9e324aebe6e1c8c21163303287477a9ddf29157"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:V25M46FDXCJ435A62MUDS2ZPMX","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Collective Properties of a Transcription Initiation Model under Varying Environment","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"John Lowengrub, Yucheng Hu","submitted_at":"2015-08-10T09:02:15Z","abstract_excerpt":"The dynamics of gene transcription is tightly regulated in eukaryotes. Recent experiments have revealed various kinds of transcriptional dynamics, such as RNA polymerase II pausing, that involves regulation at the transcription initiation stage, and the choice of different regulation pattern is closely related to the physiological functions of the target gene. Here we consider a simplified model of transcription initiation, a process including the assembly of transcription complex and the pausing and releasing of the RNA polymerase II. Focusing on the collective behaviors on a population level"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1508.02172","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:35:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"swCuB83a1qSB0SHb4jecV4eER/uSJ+xsHwx2ppWFUOCekwusHl6prOSSYFE0xySJ43zPIzfeRXPtE2F1/yzpDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T18:25:45.247352Z"},"content_sha256":"fd0267ba0e4476c18a2195c7d0a0744842b1516df9d26794042bed446af2bf02","schema_version":"1.0","event_id":"sha256:fd0267ba0e4476c18a2195c7d0a0744842b1516df9d26794042bed446af2bf02"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/V25M46FDXCJ435A62MUDS2ZPMX/bundle.json","state_url":"https://pith.science/pith/V25M46FDXCJ435A62MUDS2ZPMX/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/V25M46FDXCJ435A62MUDS2ZPMX/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T18:25:45Z","links":{"resolver":"https://pith.science/pith/V25M46FDXCJ435A62MUDS2ZPMX","bundle":"https://pith.science/pith/V25M46FDXCJ435A62MUDS2ZPMX/bundle.json","state":"https://pith.science/pith/V25M46FDXCJ435A62MUDS2ZPMX/state.json","well_known_bundle":"https://pith.science/.well-known/pith/V25M46FDXCJ435A62MUDS2ZPMX/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:V25M46FDXCJ435A62MUDS2ZPMX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"67f952c60ef1570c22b2fce3f7785e0636ce6eb36022ff93deae0655df6bf4ed","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2015-08-10T09:02:15Z","title_canon_sha256":"41cc3f877a10bc4f85ba7e789c562f48b27e780874ffbc642a95b0dfc3c39458"},"schema_version":"1.0","source":{"id":"1508.02172","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1508.02172","created_at":"2026-05-18T01:35:33Z"},{"alias_kind":"arxiv_version","alias_value":"1508.02172v1","created_at":"2026-05-18T01:35:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1508.02172","created_at":"2026-05-18T01:35:33Z"},{"alias_kind":"pith_short_12","alias_value":"V25M46FDXCJ4","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_16","alias_value":"V25M46FDXCJ435A6","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_8","alias_value":"V25M46FD","created_at":"2026-05-18T12:29:44Z"}],"graph_snapshots":[{"event_id":"sha256:fd0267ba0e4476c18a2195c7d0a0744842b1516df9d26794042bed446af2bf02","target":"graph","created_at":"2026-05-18T01:35:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The dynamics of gene transcription is tightly regulated in eukaryotes. Recent experiments have revealed various kinds of transcriptional dynamics, such as RNA polymerase II pausing, that involves regulation at the transcription initiation stage, and the choice of different regulation pattern is closely related to the physiological functions of the target gene. Here we consider a simplified model of transcription initiation, a process including the assembly of transcription complex and the pausing and releasing of the RNA polymerase II. Focusing on the collective behaviors on a population level","authors_text":"John Lowengrub, Yucheng Hu","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2015-08-10T09:02:15Z","title":"Collective Properties of a Transcription Initiation Model under Varying Environment"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1508.02172","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2919410126ac8704fadc4178e9e324aebe6e1c8c21163303287477a9ddf29157","target":"record","created_at":"2026-05-18T01:35:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"67f952c60ef1570c22b2fce3f7785e0636ce6eb36022ff93deae0655df6bf4ed","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2015-08-10T09:02:15Z","title_canon_sha256":"41cc3f877a10bc4f85ba7e789c562f48b27e780874ffbc642a95b0dfc3c39458"},"schema_version":"1.0","source":{"id":"1508.02172","kind":"arxiv","version":1}},"canonical_sha256":"aebace78a3b893cdf41ed328396b2f65c2700c92095c2535894ff1df1d9e52b2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"aebace78a3b893cdf41ed328396b2f65c2700c92095c2535894ff1df1d9e52b2","first_computed_at":"2026-05-18T01:35:33.967060Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:35:33.967060Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"iGw3Ki8vlrEKCfeb34jw12RR7jUiCrs9tfjFHpvv1EY62JTRkJVsnw1v9vWi2p4C9B1OGzkFenQ3Sqg2LNPCDg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:35:33.967804Z","signed_message":"canonical_sha256_bytes"},"source_id":"1508.02172","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2919410126ac8704fadc4178e9e324aebe6e1c8c21163303287477a9ddf29157","sha256:fd0267ba0e4476c18a2195c7d0a0744842b1516df9d26794042bed446af2bf02"],"state_sha256":"881f1927225f035dae028cb7c605226d5854b6e58141eccb7d5bb933ef8ced71"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jsdVFQWYGsJ3sIoNhiDPbF5K+aViL5GHb/mxWyd8+Sln8WN9Oh9sWamgRasbLbEahX13VQYZA3Wb4wXT/qRKDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T18:25:45.249250Z","bundle_sha256":"b8d5da4b4936ef2b3b328aa7ef4834d9e3a3225555e58918f0763016a4cb0c59"}}