{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:V25Y7QH5Z2KBMC4ZCJGSKOUGXK","short_pith_number":"pith:V25Y7QH5","canonical_record":{"source":{"id":"1105.0710","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-04T00:35:42Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"349b23d1c84af5e14eb81936c7314e36411d1c748053a53b2d79981584fda162","abstract_canon_sha256":"d45c36869ece45a67da54fbf267fdee12d6ebac4f91faf6a3f7081bc6c21a225"},"schema_version":"1.0"},"canonical_sha256":"aebb8fc0fdce94160b99124d253a86ba8fa290f584460eb69ef53a3a13ca7f4f","source":{"kind":"arxiv","id":"1105.0710","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.0710","created_at":"2026-05-18T04:08:05Z"},{"alias_kind":"arxiv_version","alias_value":"1105.0710v2","created_at":"2026-05-18T04:08:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.0710","created_at":"2026-05-18T04:08:05Z"},{"alias_kind":"pith_short_12","alias_value":"V25Y7QH5Z2KB","created_at":"2026-05-18T12:26:42Z"},{"alias_kind":"pith_short_16","alias_value":"V25Y7QH5Z2KBMC4Z","created_at":"2026-05-18T12:26:42Z"},{"alias_kind":"pith_short_8","alias_value":"V25Y7QH5","created_at":"2026-05-18T12:26:42Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:V25Y7QH5Z2KBMC4ZCJGSKOUGXK","target":"record","payload":{"canonical_record":{"source":{"id":"1105.0710","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-04T00:35:42Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"349b23d1c84af5e14eb81936c7314e36411d1c748053a53b2d79981584fda162","abstract_canon_sha256":"d45c36869ece45a67da54fbf267fdee12d6ebac4f91faf6a3f7081bc6c21a225"},"schema_version":"1.0"},"canonical_sha256":"aebb8fc0fdce94160b99124d253a86ba8fa290f584460eb69ef53a3a13ca7f4f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:08:05.176216Z","signature_b64":"pScC7s/6vf90GCd2wdcepZ0BxNJ8asxN44dQqhZ8lsnc0h7Rh6IJk/TmZdO9jG7vAU6Z80iZ8qAg7E15yvMgCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"aebb8fc0fdce94160b99124d253a86ba8fa290f584460eb69ef53a3a13ca7f4f","last_reissued_at":"2026-05-18T04:08:05.175761Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:08:05.175761Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1105.0710","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:08:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"yttM7VScoFe0bvry/ntwk73X1M6bbrnoYjgft8BDeSKMHxbyhFs1TzuhlmuG8zXDmDSX0RcaXbER2EAzgiiRAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T02:35:23.568644Z"},"content_sha256":"c229faded1269080f792cb0b5059ae534b7f42f15285b04792d78fc799d039ce","schema_version":"1.0","event_id":"sha256:c229faded1269080f792cb0b5059ae534b7f42f15285b04792d78fc799d039ce"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:V25Y7QH5Z2KBMC4ZCJGSKOUGXK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"cond-mat.stat-mech","authors_text":"John D. Chodera, Vijay S. Pande","submitted_at":"2011-05-04T00:35:42Z","abstract_excerpt":"To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed reaction coordinate. Comparison of the observed splitting probability with that computed from the kinetic model provides a simple test to reject poor reaction coordinates. We demonstrate this test for a force spectroscopy measurement of a DNA hairpin."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.0710","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:08:05Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TPCubZTN2l/gqOsti687bM71f+ZGWz8LpYd8DKcRCJvgwNyW7N4bO6dKIEyR0qjZIL+xwKPz8lMjb6KRYykBDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T02:35:23.569344Z"},"content_sha256":"e858842bfebedc9b40ea1b5946da96c7d87f6b52105b0755d290e89f3ceeafe6","schema_version":"1.0","event_id":"sha256:e858842bfebedc9b40ea1b5946da96c7d87f6b52105b0755d290e89f3ceeafe6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/V25Y7QH5Z2KBMC4ZCJGSKOUGXK/bundle.json","state_url":"https://pith.science/pith/V25Y7QH5Z2KBMC4ZCJGSKOUGXK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/V25Y7QH5Z2KBMC4ZCJGSKOUGXK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-20T02:35:23Z","links":{"resolver":"https://pith.science/pith/V25Y7QH5Z2KBMC4ZCJGSKOUGXK","bundle":"https://pith.science/pith/V25Y7QH5Z2KBMC4ZCJGSKOUGXK/bundle.json","state":"https://pith.science/pith/V25Y7QH5Z2KBMC4ZCJGSKOUGXK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/V25Y7QH5Z2KBMC4ZCJGSKOUGXK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:V25Y7QH5Z2KBMC4ZCJGSKOUGXK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d45c36869ece45a67da54fbf267fdee12d6ebac4f91faf6a3f7081bc6c21a225","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-04T00:35:42Z","title_canon_sha256":"349b23d1c84af5e14eb81936c7314e36411d1c748053a53b2d79981584fda162"},"schema_version":"1.0","source":{"id":"1105.0710","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.0710","created_at":"2026-05-18T04:08:05Z"},{"alias_kind":"arxiv_version","alias_value":"1105.0710v2","created_at":"2026-05-18T04:08:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.0710","created_at":"2026-05-18T04:08:05Z"},{"alias_kind":"pith_short_12","alias_value":"V25Y7QH5Z2KB","created_at":"2026-05-18T12:26:42Z"},{"alias_kind":"pith_short_16","alias_value":"V25Y7QH5Z2KBMC4Z","created_at":"2026-05-18T12:26:42Z"},{"alias_kind":"pith_short_8","alias_value":"V25Y7QH5","created_at":"2026-05-18T12:26:42Z"}],"graph_snapshots":[{"event_id":"sha256:e858842bfebedc9b40ea1b5946da96c7d87f6b52105b0755d290e89f3ceeafe6","target":"graph","created_at":"2026-05-18T04:08:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed reaction coordinate. Comparison of the observed splitting probability with that computed from the kinetic model provides a simple test to reject poor reaction coordinates. We demonstrate this test for a force spectroscopy measurement of a DNA hairpin.","authors_text":"John D. Chodera, Vijay S. Pande","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-04T00:35:42Z","title":"Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.0710","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c229faded1269080f792cb0b5059ae534b7f42f15285b04792d78fc799d039ce","target":"record","created_at":"2026-05-18T04:08:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d45c36869ece45a67da54fbf267fdee12d6ebac4f91faf6a3f7081bc6c21a225","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2011-05-04T00:35:42Z","title_canon_sha256":"349b23d1c84af5e14eb81936c7314e36411d1c748053a53b2d79981584fda162"},"schema_version":"1.0","source":{"id":"1105.0710","kind":"arxiv","version":2}},"canonical_sha256":"aebb8fc0fdce94160b99124d253a86ba8fa290f584460eb69ef53a3a13ca7f4f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"aebb8fc0fdce94160b99124d253a86ba8fa290f584460eb69ef53a3a13ca7f4f","first_computed_at":"2026-05-18T04:08:05.175761Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:08:05.175761Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"pScC7s/6vf90GCd2wdcepZ0BxNJ8asxN44dQqhZ8lsnc0h7Rh6IJk/TmZdO9jG7vAU6Z80iZ8qAg7E15yvMgCA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:08:05.176216Z","signed_message":"canonical_sha256_bytes"},"source_id":"1105.0710","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c229faded1269080f792cb0b5059ae534b7f42f15285b04792d78fc799d039ce","sha256:e858842bfebedc9b40ea1b5946da96c7d87f6b52105b0755d290e89f3ceeafe6"],"state_sha256":"f12e9df01f79c86f1aa2cf39565e5743cc6677625c9a73ecfdda0ea8451ef8d8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ARbB1JAv3yvhGpsurwqdNG17gnL7QAL9CCY4/3EzkMsnf8CPYjzN0Mvq8CvuT0Kdn/pW02Y1PpbpN4x/byEgBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-20T02:35:23.573927Z","bundle_sha256":"c9043e1f6b29265b2072e549a8ed3ac6480646c66c2b7f430e60037debb4855b"}}