{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:V3BSJ7C4MYUPZFIBCOBIM3YIHG","short_pith_number":"pith:V3BSJ7C4","canonical_record":{"source":{"id":"1512.00299","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-01T15:38:40Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"title_canon_sha256":"7fcb0f75b66048b804ef2e4f1749995b7bdc61d60b1e3e7611fda98ecd23b2a3","abstract_canon_sha256":"d2bbf63ccedec74ec016393a597b57bad6816c3f2f2fd7f730bc58d7615ffbe4"},"schema_version":"1.0"},"canonical_sha256":"aec324fc5c6628fc95011382866f08398e155b38383615c948c136516e2ace57","source":{"kind":"arxiv","id":"1512.00299","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.00299","created_at":"2026-05-18T01:25:32Z"},{"alias_kind":"arxiv_version","alias_value":"1512.00299v1","created_at":"2026-05-18T01:25:32Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.00299","created_at":"2026-05-18T01:25:32Z"},{"alias_kind":"pith_short_12","alias_value":"V3BSJ7C4MYUP","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_16","alias_value":"V3BSJ7C4MYUPZFIB","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_8","alias_value":"V3BSJ7C4","created_at":"2026-05-18T12:29:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:V3BSJ7C4MYUPZFIBCOBIM3YIHG","target":"record","payload":{"canonical_record":{"source":{"id":"1512.00299","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-01T15:38:40Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"title_canon_sha256":"7fcb0f75b66048b804ef2e4f1749995b7bdc61d60b1e3e7611fda98ecd23b2a3","abstract_canon_sha256":"d2bbf63ccedec74ec016393a597b57bad6816c3f2f2fd7f730bc58d7615ffbe4"},"schema_version":"1.0"},"canonical_sha256":"aec324fc5c6628fc95011382866f08398e155b38383615c948c136516e2ace57","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:25:32.288183Z","signature_b64":"07CUdLPjlc3MUYjT3sZ9w+78iEaFz/4LIMHtyNpsDiUp8U/1vrFGiRLz35lI7CT6dkAPS3mmU20wpgns/0XXCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"aec324fc5c6628fc95011382866f08398e155b38383615c948c136516e2ace57","last_reissued_at":"2026-05-18T01:25:32.287526Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:25:32.287526Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1512.00299","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:25:32Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"puPjmLEY68crIa8B3d9Y8gnDVW3ikmi8XExVRFjAc+tjCVzbeUDTwlU+LXhediQAMf8vUbhKACZPd0HgaWBPDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T09:30:26.625692Z"},"content_sha256":"670e211ccfa6592e16bcb2208f66679f9eb9f3549aae8ee38185cc7d1641e0b6","schema_version":"1.0","event_id":"sha256:670e211ccfa6592e16bcb2208f66679f9eb9f3549aae8ee38185cc7d1641e0b6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:V3BSJ7C4MYUPZFIBCOBIM3YIHG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"On the importance of hydrodynamic interactions in the stepping kinetics of kinesin","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"D. Thirumalai, Yonathan Goldtzvik, Zhechun Zhang","submitted_at":"2015-12-01T15:38:40Z","abstract_excerpt":"Conventional kinesin walks by a hand-over-hand mechanism on the microtubule (MT) by taking $\\sim$ 8$nm$ discrete steps, and consumes one ATP molecule per step. The time needed to complete a single step is on the order of twenty microseconds. We show, using simulations of a coarse-grained model of the complex containing the two motor heads, the MT, and the coiled coil that in order to obtain quantitative agreement with experiments for the stepping kinetics hydrodynamic interactions (HI) have to be included. In simulations without hydrodynamic interactions spanning nearly twenty $\\mu$s not a sin"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.00299","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:25:32Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sUFFYpj+A+Pdu4qdPkSr1ZtYC4Xpwk9WW0Ave6pUkRJXllCFC29aPTMjXYcu9b4YS1vueFFrbVpgAPPDW71MCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T09:30:26.626045Z"},"content_sha256":"5ac809cd5ae965e9042e562ae5f15aec86f638c9ff03afd068948c80c7d96a8e","schema_version":"1.0","event_id":"sha256:5ac809cd5ae965e9042e562ae5f15aec86f638c9ff03afd068948c80c7d96a8e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/V3BSJ7C4MYUPZFIBCOBIM3YIHG/bundle.json","state_url":"https://pith.science/pith/V3BSJ7C4MYUPZFIBCOBIM3YIHG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/V3BSJ7C4MYUPZFIBCOBIM3YIHG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-05T09:30:26Z","links":{"resolver":"https://pith.science/pith/V3BSJ7C4MYUPZFIBCOBIM3YIHG","bundle":"https://pith.science/pith/V3BSJ7C4MYUPZFIBCOBIM3YIHG/bundle.json","state":"https://pith.science/pith/V3BSJ7C4MYUPZFIBCOBIM3YIHG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/V3BSJ7C4MYUPZFIBCOBIM3YIHG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:V3BSJ7C4MYUPZFIBCOBIM3YIHG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d2bbf63ccedec74ec016393a597b57bad6816c3f2f2fd7f730bc58d7615ffbe4","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-01T15:38:40Z","title_canon_sha256":"7fcb0f75b66048b804ef2e4f1749995b7bdc61d60b1e3e7611fda98ecd23b2a3"},"schema_version":"1.0","source":{"id":"1512.00299","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.00299","created_at":"2026-05-18T01:25:32Z"},{"alias_kind":"arxiv_version","alias_value":"1512.00299v1","created_at":"2026-05-18T01:25:32Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.00299","created_at":"2026-05-18T01:25:32Z"},{"alias_kind":"pith_short_12","alias_value":"V3BSJ7C4MYUP","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_16","alias_value":"V3BSJ7C4MYUPZFIB","created_at":"2026-05-18T12:29:44Z"},{"alias_kind":"pith_short_8","alias_value":"V3BSJ7C4","created_at":"2026-05-18T12:29:44Z"}],"graph_snapshots":[{"event_id":"sha256:5ac809cd5ae965e9042e562ae5f15aec86f638c9ff03afd068948c80c7d96a8e","target":"graph","created_at":"2026-05-18T01:25:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Conventional kinesin walks by a hand-over-hand mechanism on the microtubule (MT) by taking $\\sim$ 8$nm$ discrete steps, and consumes one ATP molecule per step. The time needed to complete a single step is on the order of twenty microseconds. We show, using simulations of a coarse-grained model of the complex containing the two motor heads, the MT, and the coiled coil that in order to obtain quantitative agreement with experiments for the stepping kinetics hydrodynamic interactions (HI) have to be included. In simulations without hydrodynamic interactions spanning nearly twenty $\\mu$s not a sin","authors_text":"D. Thirumalai, Yonathan Goldtzvik, Zhechun Zhang","cross_cats":["cond-mat.stat-mech","q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-01T15:38:40Z","title":"On the importance of hydrodynamic interactions in the stepping kinetics of kinesin"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.00299","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:670e211ccfa6592e16bcb2208f66679f9eb9f3549aae8ee38185cc7d1641e0b6","target":"record","created_at":"2026-05-18T01:25:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d2bbf63ccedec74ec016393a597b57bad6816c3f2f2fd7f730bc58d7615ffbe4","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-01T15:38:40Z","title_canon_sha256":"7fcb0f75b66048b804ef2e4f1749995b7bdc61d60b1e3e7611fda98ecd23b2a3"},"schema_version":"1.0","source":{"id":"1512.00299","kind":"arxiv","version":1}},"canonical_sha256":"aec324fc5c6628fc95011382866f08398e155b38383615c948c136516e2ace57","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"aec324fc5c6628fc95011382866f08398e155b38383615c948c136516e2ace57","first_computed_at":"2026-05-18T01:25:32.287526Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:25:32.287526Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"07CUdLPjlc3MUYjT3sZ9w+78iEaFz/4LIMHtyNpsDiUp8U/1vrFGiRLz35lI7CT6dkAPS3mmU20wpgns/0XXCA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:25:32.288183Z","signed_message":"canonical_sha256_bytes"},"source_id":"1512.00299","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:670e211ccfa6592e16bcb2208f66679f9eb9f3549aae8ee38185cc7d1641e0b6","sha256:5ac809cd5ae965e9042e562ae5f15aec86f638c9ff03afd068948c80c7d96a8e"],"state_sha256":"3f92d3070ec2a62dad54db1db155be1e819cd56996f97d694b006c1c9988c4f1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/V+tLbYrD8xH3uD6SxxZ3+uIXqVPJrmur+WrzZPRmXjOA2NNlAdvkUBs85nXmumCoCICMjONTtsuKATn1UVSAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-05T09:30:26.628138Z","bundle_sha256":"87ef3c3d41688f9297ad693c63870d6f7843cdd8bbca7b2b392b95b51c0a0a5e"}}