{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:V7SFH3Q74V53GG5D22XDX4TZDA","short_pith_number":"pith:V7SFH3Q7","canonical_record":{"source":{"id":"2502.16986","kind":"arxiv","version":4},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-02-24T09:19:46Z","cross_cats_sorted":[],"title_canon_sha256":"5f061262d88dfda2333b2710c0cbf30a2888508e7d98ca580f0761a931c23e7a","abstract_canon_sha256":"1ffa574abb763388845fa07811bd08fc0bf5a2e1296c3d27d02d4ebf8f64eda0"},"schema_version":"1.0"},"canonical_sha256":"afe453ee1fe57bb31ba3d6ae3bf279182d3860444cca876b2e11deb62928736c","source":{"kind":"arxiv","id":"2502.16986","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.16986","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"arxiv_version","alias_value":"2502.16986v4","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.16986","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"pith_short_12","alias_value":"V7SFH3Q74V53","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"pith_short_16","alias_value":"V7SFH3Q74V53GG5D","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"pith_short_8","alias_value":"V7SFH3Q7","created_at":"2026-07-05T12:11:15Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:V7SFH3Q74V53GG5D22XDX4TZDA","target":"record","payload":{"canonical_record":{"source":{"id":"2502.16986","kind":"arxiv","version":4},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-02-24T09:19:46Z","cross_cats_sorted":[],"title_canon_sha256":"5f061262d88dfda2333b2710c0cbf30a2888508e7d98ca580f0761a931c23e7a","abstract_canon_sha256":"1ffa574abb763388845fa07811bd08fc0bf5a2e1296c3d27d02d4ebf8f64eda0"},"schema_version":"1.0"},"canonical_sha256":"afe453ee1fe57bb31ba3d6ae3bf279182d3860444cca876b2e11deb62928736c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T12:11:15.616557Z","signature_b64":"OmbRjn9/2a3wt9E/hTa93WM4SqYjiy+QRxr+7nxxWEpapYYwtJ48agCBF7+nFliCuzAmR7VLXoiPZEBLWc8vDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"afe453ee1fe57bb31ba3d6ae3bf279182d3860444cca876b2e11deb62928736c","last_reissued_at":"2026-07-05T12:11:15.615955Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T12:11:15.615955Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2502.16986","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T12:11:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3F7FBB03E59Pxtj2VGOokAJcL/Ws2mrFUpE36yw0Hk/ublgia4W35vvfWXnJMb98ncRiHMxBj/BdcNg2x9MCDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T09:05:22.541500Z"},"content_sha256":"b8fc327242040594024830a0a4da38728f642541d878eefda24239b29402f72d","schema_version":"1.0","event_id":"sha256:b8fc327242040594024830a0a4da38728f642541d878eefda24239b29402f72d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:V7SFH3Q74V53GG5D22XDX4TZDA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A framework for rapid, reproducible, and high-fidelity whole-brain multi-pool CEST imaging at 3T","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Caixia Fu, Jianqi Li, Siyuan Fang, Siyuan Wang, Yupeng Wu","submitted_at":"2025-02-24T09:19:46Z","abstract_excerpt":"Purpose: To develop and validate a framework for rapid, accurate, and reproducible whole-brain, multi-pool chemical exchange saturation transfer (CEST) imaging at 3T, addressing challenges of long acquisition times and confounding factors. Methods: A single-shot 3D true fast imaging with steady-state precession (True FISP) sequence was optimized for whole-brain multi-pool CEST. Rapid B0, B1, and T1 mapping was performed using a dual-echo modified four-angle method. A feed-forward neural network was developed for rapid B1 correction, trained against the conventional multi-power method. The appa"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.16986","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2502.16986/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T12:11:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CZZWtyt8+ekXNpJVkMKrOpmZUGxJ24MFQYcAbjtpg4TyP7FvkbXlrmeVG331XYiPgdwOBjQJeXF6oYlgEsq9Cg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T09:05:22.542590Z"},"content_sha256":"a199bc4e0c8e76ab39f5c484c54ace51ee1bb315fed5ac256269a9d61841730c","schema_version":"1.0","event_id":"sha256:a199bc4e0c8e76ab39f5c484c54ace51ee1bb315fed5ac256269a9d61841730c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/V7SFH3Q74V53GG5D22XDX4TZDA/bundle.json","state_url":"https://pith.science/pith/V7SFH3Q74V53GG5D22XDX4TZDA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/V7SFH3Q74V53GG5D22XDX4TZDA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-06T09:05:22Z","links":{"resolver":"https://pith.science/pith/V7SFH3Q74V53GG5D22XDX4TZDA","bundle":"https://pith.science/pith/V7SFH3Q74V53GG5D22XDX4TZDA/bundle.json","state":"https://pith.science/pith/V7SFH3Q74V53GG5D22XDX4TZDA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/V7SFH3Q74V53GG5D22XDX4TZDA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:V7SFH3Q74V53GG5D22XDX4TZDA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1ffa574abb763388845fa07811bd08fc0bf5a2e1296c3d27d02d4ebf8f64eda0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-02-24T09:19:46Z","title_canon_sha256":"5f061262d88dfda2333b2710c0cbf30a2888508e7d98ca580f0761a931c23e7a"},"schema_version":"1.0","source":{"id":"2502.16986","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.16986","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"arxiv_version","alias_value":"2502.16986v4","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.16986","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"pith_short_12","alias_value":"V7SFH3Q74V53","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"pith_short_16","alias_value":"V7SFH3Q74V53GG5D","created_at":"2026-07-05T12:11:15Z"},{"alias_kind":"pith_short_8","alias_value":"V7SFH3Q7","created_at":"2026-07-05T12:11:15Z"}],"graph_snapshots":[{"event_id":"sha256:a199bc4e0c8e76ab39f5c484c54ace51ee1bb315fed5ac256269a9d61841730c","target":"graph","created_at":"2026-07-05T12:11:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2502.16986/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Purpose: To develop and validate a framework for rapid, accurate, and reproducible whole-brain, multi-pool chemical exchange saturation transfer (CEST) imaging at 3T, addressing challenges of long acquisition times and confounding factors. Methods: A single-shot 3D true fast imaging with steady-state precession (True FISP) sequence was optimized for whole-brain multi-pool CEST. Rapid B0, B1, and T1 mapping was performed using a dual-echo modified four-angle method. A feed-forward neural network was developed for rapid B1 correction, trained against the conventional multi-power method. The appa","authors_text":"Caixia Fu, Jianqi Li, Siyuan Fang, Siyuan Wang, Yupeng Wu","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-02-24T09:19:46Z","title":"A framework for rapid, reproducible, and high-fidelity whole-brain multi-pool CEST imaging at 3T"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.16986","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b8fc327242040594024830a0a4da38728f642541d878eefda24239b29402f72d","target":"record","created_at":"2026-07-05T12:11:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1ffa574abb763388845fa07811bd08fc0bf5a2e1296c3d27d02d4ebf8f64eda0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-02-24T09:19:46Z","title_canon_sha256":"5f061262d88dfda2333b2710c0cbf30a2888508e7d98ca580f0761a931c23e7a"},"schema_version":"1.0","source":{"id":"2502.16986","kind":"arxiv","version":4}},"canonical_sha256":"afe453ee1fe57bb31ba3d6ae3bf279182d3860444cca876b2e11deb62928736c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"afe453ee1fe57bb31ba3d6ae3bf279182d3860444cca876b2e11deb62928736c","first_computed_at":"2026-07-05T12:11:15.615955Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T12:11:15.615955Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"OmbRjn9/2a3wt9E/hTa93WM4SqYjiy+QRxr+7nxxWEpapYYwtJ48agCBF7+nFliCuzAmR7VLXoiPZEBLWc8vDg==","signature_status":"signed_v1","signed_at":"2026-07-05T12:11:15.616557Z","signed_message":"canonical_sha256_bytes"},"source_id":"2502.16986","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b8fc327242040594024830a0a4da38728f642541d878eefda24239b29402f72d","sha256:a199bc4e0c8e76ab39f5c484c54ace51ee1bb315fed5ac256269a9d61841730c"],"state_sha256":"124f09060ba1c69244516788fecd7fa06d675a58659785aa48a8398cce6c24b1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kUZEmir25fDE+5CI9YO1dB6EWawgRO6Ng+V772nmE/gZV23b+A7X1rojdvJMiAbBF633ampQmHCZ5pt3KFARDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-06T09:05:22.548099Z","bundle_sha256":"8d2baa188ce5a45e9efe74f1ef80067ff6bac7aee12658443beac693b69c012b"}}